Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Robert F, Hillary"'
Autor:
Danni A. Gadd, Hannah M. Smith, Donncha Mullin, Ola Chybowska, Robert F. Hillary, Dorien M. Kimenai, Elena Bernabeu, Yipeng Cheng, Chloe Fawns-Ritchie, Archie Campbell, Danielle Page, Adele Taylor, Janie Corley, Maria Del C. Valdés-Hernández, Susana Muñoz Maniega, Mark E. Bastin, Joanna M. Wardlaw, Rosie M. Walker, Kathryn L. Evans, Andrew M. McIntosh, Caroline Hayward, Tom C. Russ, Sarah E. Harris, Paul Welsh, Naveed Sattar, Simon R. Cox, Daniel L. McCartney, Riccardo E. Marioni
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Plasma growth differentiation factor 15 (GDF15) and N‐terminal proB‐type natriuretic peptide (NT‐proBNP) are cardiovascular biomarkers that associate with a range of diseases. Epigenetic scores (EpiScores) for GDF15 and NT-p
Externí odkaz:
https://doaj.org/article/76e8233ab631452ab514eb985f52d351
Autor:
Robert F. Hillary, Danni A. Gadd, Zhana Kuncheva, Tasos Mangelis, Tinchi Lin, Kyle Ferber, Helen McLaughlin, Heiko Runz, Biogen Biobank Team, Riccardo E. Marioni, Christopher N. Foley, Benjamin B. Sun
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Understanding how gene-environment interactions (GEIs) influence the circulating proteome could aid in biomarker discovery and validation. The presence of GEIs can be inferred from single nucleotide polymorphisms that associate with phenotyp
Externí odkaz:
https://doaj.org/article/b3af4159742445ef8cc58e96088e9052
Autor:
Katie Mckinnon, Eleanor L. S. Conole, Kadi Vaher, Robert F. Hillary, Danni A. Gadd, Justyna Binkowska, Gemma Sullivan, Anna J. Stevenson, Amy Corrigan, Lee Murphy, Heather C. Whalley, Hilary Richardson, Riccardo E. Marioni, Simon R. Cox, James P. Boardman
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Epigenetic scores (EpiScores), reflecting DNA methylation (DNAm)-based surrogates for complex traits, have been developed for multiple circulating proteins. EpiScores for pro-inflammatory proteins, such as C-reactive protein (DNAm
Externí odkaz:
https://doaj.org/article/a9cea3b05e5c4db6b4d9d4b171d871d0
Autor:
Hannah M. Smith, Joanna E. Moodie, Karla Monterrubio-Gómez, Danni A. Gadd, Robert F. Hillary, Aleksandra D. Chybowska, Daniel L. McCartney, Archie Campbell, Paul Redmond, Danielle Page, Adele Taylor, Janie Corley, Sarah E. Harris, Maria Valdés Hernández, Susana Muñoz Maniega, Mark E. Bastin, Joanna M. Wardlaw, Ian J. Deary, James P. Boardman, Donncha S. Mullin, Tom C. Russ, Simon R. Cox, Riccardo E. Marioni
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Background Epigenetic Scores (EpiScores) for blood protein levels have been associated with disease outcomes and measures of brain health, highlighting their potential usefulness as clinical biomarkers. They are typically derived via penalis
Externí odkaz:
https://doaj.org/article/3c13220e7e174e5f8add934cd767d03c
Autor:
Charlotte Merzbacher, Barry Ryan, Thibaut Goldsborough, Robert F. Hillary, Archie Campbell, Lee Murphy, Andrew M. McIntosh, David Liewald, Sarah E. Harris, Allan F. McRae, Simon R. Cox, Timothy I. Cannings, Catalina A. Vallejos, Daniel L. McCartney, Riccardo E. Marioni
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Epigenetic scores (EpiScores) can provide biomarkers of lifestyle and disease risk. Projecting new datasets onto a reference panel is challenging due to separation of technical and biological variation with array data. Normalisati
Externí odkaz:
https://doaj.org/article/27a94f213069468c9e6bc2caa52439dc
Autor:
Danni A Gadd, Robert F Hillary, Daniel L McCartney, Shaza B Zaghlool, Anna J Stevenson, Yipeng Cheng, Chloe Fawns-Ritchie, Cliff Nangle, Archie Campbell, Robin Flaig, Sarah E Harris, Rosie M Walker, Liu Shi, Elliot M Tucker-Drob, Christian Gieger, Annette Peters, Melanie Waldenberger, Johannes Graumann, Allan F McRae, Ian J Deary, David J Porteous, Caroline Hayward, Peter M Visscher, Simon R Cox, Kathryn L Evans, Andrew M McIntosh, Karsten Suhre, Riccardo E Marioni
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/49877892abd24e60be24474ec13ce578
Autor:
Elena Bernabeu, Daniel L. McCartney, Danni A. Gadd, Robert F. Hillary, Ake T. Lu, Lee Murphy, Nicola Wrobel, Archie Campbell, Sarah E. Harris, David Liewald, Caroline Hayward, Cathie Sudlow, Simon R. Cox, Kathryn L. Evans, Steve Horvath, Andrew M. McIntosh, Matthew R. Robinson, Catalina A. Vallejos, Riccardo E. Marioni
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Epigenetic clocks can track both chronological age (cAge) and biological age (bAge). The latter is typically defined by physiological biomarkers and risk of adverse health outcomes, including all-cause mortality. As cohort sample
Externí odkaz:
https://doaj.org/article/11ded94b605a495a931ef5473f213f7c
Autor:
Robert F Hillary, Daniel L McCartney, Hannah M Smith, Elena Bernabeu, Danni A Gadd, Aleksandra D Chybowska, Yipeng Cheng, Lee Murphy, Nicola Wrobel, Archie Campbell, Rosie M Walker, Caroline Hayward, Kathryn L Evans, Andrew M McIntosh, Riccardo E Marioni
Publikováno v:
PLoS Medicine, Vol 20, Iss 7, p e1004247 (2023)
BackgroundDNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) investigate the strength of association between methylation at individual CpG si
Externí odkaz:
https://doaj.org/article/f0b1e6cceb97419e8873e65cb9b0489b
Autor:
Danni A. Gadd, Robert F. Hillary, Daniel L. McCartney, Liu Shi, Aleks Stolicyn, Neil A. Robertson, Rosie M. Walker, Robert I. McGeachan, Archie Campbell, Shen Xueyi, Miruna C. Barbu, Claire Green, Stewart W. Morris, Mathew A. Harris, Ellen V. Backhouse, Joanna M. Wardlaw, J. Douglas Steele, Diego A. Oyarzún, Graciela Muniz-Terrera, Craig Ritchie, Alejo Nevado-Holgado, Tamir Chandra, Caroline Hayward, Kathryn L. Evans, David J. Porteous, Simon R. Cox, Heather C. Whalley, Andrew M. McIntosh, Riccardo E. Marioni
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Characterising associations between the methylome, proteome and phenome may provide insight into biological pathways governing brain health. Here, blood protein markers of brain health are integrated with omics data to reveal DNA methylation differen
Externí odkaz:
https://doaj.org/article/1eaa7fc6efbf4260a056871f0b0cae03
Autor:
Rebecca A. Madden, Kimberley Atkinson, Xueyi Shen, Claire Green, Robert F. Hillary, Emma Hawkins, Emma Såge, Anca-Larisa Sandu, Gordon Waiter, Christopher McNeil, Mathew Harris, Archie Campbell, David Porteous, Jennifer A. Macfarlane, Alison Murray, Douglas Steele, Liana Romaniuk, Stephen M. Lawrie, Andrew M. McIntosh, Heather C. Whalley
Publikováno v:
European Psychiatry, Vol 66 (2023)
Abstract Introduction Childhood trauma and adversity are common across societies and have strong associations with physical and psychiatric morbidity throughout the life-course. One possible mechanism through which childhood trauma may predispose in
Externí odkaz:
https://doaj.org/article/fd57a95524dd4b0cbc18d0a10997de82