Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Robert F, Hennigan"'
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281876 (2023)
Neurofibromatosis Type 2 is an inherited disease characterized by Schwann cell tumors of cranial and peripheral nerves. The NF2 gene encodes Merlin, a member of the ERM family consisting of an N-terminal FERM domain, a central α-helical region, and
Externí odkaz:
https://doaj.org/article/f999f2a55ba541cbb2dca0312033a332
Autor:
Robert A. Coover, Tabitha E. Healy, Li Guo, Katherine E. Chaney, Robert F. Hennigan, Craig S. Thomson, Lindsey E. Aschbacher-Smith, Michael P. Jankowski, Nancy Ratner
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released from the nerve in an activity dependent manner. We find that suppressing nerve activity in adult nerves causes SC to enter the cell cycle. In vitro, ATP activates
Externí odkaz:
https://doaj.org/article/1bfa1d5d9ede4c02abd2406952f3a5c2
Neurofibromatosis Type 2 is an inherited disease characterized by Schwann cell tumors of cranial and peripheral nerves. The NF2 gene encodes Merlin, a member of the ERM family consisting of an N-terminal FERM domain, a central α-helical region and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7549b41334a0c9acaf11793c2a2f30d
https://doi.org/10.1101/2021.11.11.468247
https://doi.org/10.1101/2021.11.11.468247
Autor:
Robert J. Spinner, Jennifer Patritti-Cram, Katherine E. Chaney, Shinji Kuninaka, Jose A. Cancelas, Jianqiang Wu, Robert F. Hennigan, Tilat A. Rizvi, Robert A. Coover, Ramya Ravindran, Nancy Ratner
Neurofibromatosis type 1 (NF1) is a genetic disorder characterized by nerve tumors called neurofibromas, in which Schwann cells (SCs) lack NF1 and show deregulated RAS signaling. NF1 is also implicated in regulation of cAMP. Gene expression profiling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ece2c5eedcfa53c2a480999cdb4b267
https://doi.org/10.1101/2021.09.24.461701
https://doi.org/10.1101/2021.09.24.461701
Autor:
Nancy Ratner, Jennifer Patritti Cram, Jianqiang Wu, Robert J. Spinner, David A. Largaespada, Shinji Kuninaka, Jose A. Cancelas, Eric P. Rahrmann, Tilat A. Rizvi, Robert F. Hennigan, Robert A. Coover, Katherine E. Chaney
Publikováno v:
SSRN Electronic Journal.
Neurofibromatosis type 1 (NF1) is a genetic disorder characterized by nerve tumors called neurofibromas. Expression profiling of human Schwann cells (SCs) and neurofibroma SC precursors (SCPs) identified enriched P2RY14 expression in neurofibroma SCP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b0974da738915796f1c75f77f736ca6
https://doi.org/10.2139/ssrn.3854706
https://doi.org/10.2139/ssrn.3854706
Autor:
Robert A. Coover, Jonathan Rose, Youjin Na, Jianqiang Wu, Subbaya Subramanian, Eva Dombi, Mi-Ok Kim, Liang Hu, Ashley Hall, Adam Miller, Robert F. Hennigan, Nancy Ratner, Kwangmin Choi
Publikováno v:
Oncogene
MicroRNAs (miRs) are small non-coding RNAs that can have large impacts on oncogenic pathways. Possible functions of dysregulated miRs have not been studied in neurofibromatosis type 1 (NF1) plexiform neurofibromas (PNFs). In PNFs, Schwann cells (SCs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db070df80e8e354936b4e776dc914a3
https://pubmed.ncbi.nlm.nih.gov/33293695
https://pubmed.ncbi.nlm.nih.gov/33293695
Autor:
Craig S. Thomson, Lindsey Aschbacher-Smith, Katherine E. Chaney, Michael P. Jankowski, Nancy Ratner, Li Guo, Robert A. Coover, Tabitha E. Healy, Robert F. Hennigan
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-15 (2018)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released from the nerve in an activity dependent manner. We find that suppressing nerve activity in adult nerves causes SC to enter the cell cycle. In vitro, ATP activates the SC G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6480fe5914fd6ad791d989b3961291
http://link.springer.com/article/10.1186/s40478-018-0635-9
http://link.springer.com/article/10.1186/s40478-018-0635-9
Publikováno v:
Science Signaling. 12
Neurofibromatosis type 2 is an inherited, neoplastic disease associated with schwannomas, meningiomas, and ependymomas and that is caused by inactivation of the tumor suppressor gene NF2.immortalized mouse The NF2 gene product, Merlin, has no intrins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ca2ea866101bde462c25ba5953b1ef
https://doi.org/10.1126/scisignal.aau8749
https://doi.org/10.1126/scisignal.aau8749
Autor:
Paul F. Lambert, Robert F. Hennigan, Susanne I. Wells, Ferdinand Kappes, Bruce J. Aronow, Monica L. DeLay, Marie C. Matrka
Publikováno v:
Cell Cycle. 14:3939-3953
The DEK gene encodes a nuclear protein that binds chromatin and is involved in various fundamental nuclear processes including transcription, RNA splicing, DNA replication and DNA repair. Several cancer types characteristically over-express DEK at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2e6d67ee50ad1b5ae5a6d404c1f0e0
https://doi.org/10.1080/15384101.2015.1044177
https://doi.org/10.1080/15384101.2015.1044177
Autor:
Robert F. Hennigan, Sarah H. Berth, Linda M. Parysek, Scott T. Brady, Chandra Moon, Kelly R. Monk, Gerardo Morfini, Nancy Ratner
Publikováno v:
Oncogene
Neurofibromatosis type 2 patients develop schwannomas, meningiomas and ependymomas resulting from mutations in the tumor suppressor gene, NF2, encoding a membrane-cytoskeleton adapter protein called merlin. Merlin regulates contact inhibition of grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db3795606836468898423c78142fe38
https://doi.org/10.1038/onc.2012.135
https://doi.org/10.1038/onc.2012.135