Zobrazeno 1 - 10
of 413
pro vyhledávání: '"Robert F, Dannals"'
Autor:
Catherine A. Foss, Ravi Naik, Deepankar Das, Hyojin Cha, Il Minn, Andrew Hall, Paige Finley, Sophia Jiang Wu, Yong Du, Robert F. Dannals, Martin G. Pomper, Andrew G. Horti
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Background Reactive microglia and recruited peripheral macrophages contribute to the pathogenesis of Alzheimer’s dementia (AD). Monocytes, macrophages and microglia all express the marker colony-stimulating factor 1 receptor (CSF1R). 4-Cya
Externí odkaz:
https://doaj.org/article/ff0a8477f87b447c94ffbf280583166c
Autor:
Filipa Mota, Camilo A. Ruiz-Bedoya, Elizabeth W. Tucker, Daniel P. Holt, Patricia De Jesus, Martin A. Lodge, Clara Erice, Xueyi Chen, Melissa Bahr, Kelly Flavahan, John Kim, Mary Katherine Brosnan, Alvaro A. Ordonez, Charles A. Peloquin, Robert F. Dannals, Sanjay K. Jain
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Pretomanid has been approved for use in cases of multi-drug resistant pulmonary tuberculosis, yet the penetration of this antibiotic into other target tissues is not well established. Authors provide insight on pretomanid pharmacokinetics in the cent
Externí odkaz:
https://doaj.org/article/f0a782321c4e4e36aa37ab969660b2e2
Autor:
Jennifer M. Coughlin, Yong Du, Wojciech G. Lesniak, Courtney K. Harrington, Mary Katherine Brosnan, Riley O’Toole, Adeline Zandi, Shannon Eileen Sweeney, Rehab Abdallah, Yunkou Wu, Daniel P. Holt, Andrew W. Hall, Robert F. Dannals, Lilja Solnes, Andrew G. Horti, Martin G. Pomper
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Purpose Study of the contribution of microglia to onset and course of several neuropsychiatric conditions is challenged by the fact that these resident immune cells often take on different phenotypes and functions outside the living brain. I
Externí odkaz:
https://doaj.org/article/76ad44458537447c9f4f54f7ef2310a0
Autor:
Gwenn S. Smith, Hillary Protas, Hiroto Kuwabara, Alena Savonenko, Najlla Nassery, Neda F. Gould, Michael Kraut, Dimitri Avramopoulos, Daniel Holt, Robert F. Dannals, Ayon Nandi, Yi Su, Eric M. Reiman, Kewei Chen
Publikováno v:
NeuroImage: Clinical, Vol 37, Iss , Pp 103322- (2023)
Background: Degeneration of the serotonin system has been observed in Alzheimer’s disease (AD) and in mild cognitive impairment (MCI). In transgenic amyloid mouse models, serotonin degeneration is detected prior to widespread cortical beta-amyloid
Externí odkaz:
https://doaj.org/article/9f77b3ae48cb4778880522ffadcdb828
Autor:
Farina J. Mahmud, Yong Du, Elizabeth Greif, Thomas Boucher, Robert F. Dannals, William B. Mathews, Martin G. Pomper, Polina Sysa-Shah, Kelly A. Metcalf Pate, Claire Lyons, Bess Carlson, Maria Chacona, Amanda M. Brown
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-16 (2020)
Abstract Background Osteopontin (OPN) as a secreted signaling protein is dramatically induced in response to cellular injury and neurodegeneration. Microglial inflammatory responses in the brain are tightly associated with the neuropathologic hallmar
Externí odkaz:
https://doaj.org/article/c85ad960ae0c48588fe50751766e899f
Autor:
Yong Du, Il Minn, Catherine Foss, Wojciech G. Lesniak, Feng Hu, Robert F. Dannals, Martin G. Pomper, Andrew G. Horti
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Purpose Soluble epoxide hydrolase (sEH) is a promising candidate positron emission tomography (PET) imaging biomarker altered in various disorders, including vascular cognitive impairment (VCI), Alzheimer’s disease (AD), Parkinson’s dise
Externí odkaz:
https://doaj.org/article/e7c8b691e87349a285de9b14fa0975b5
Autor:
Alvaro A. Ordonez, Matthew F.L. Parker, Robert J. Miller, Donika Plyku, Camilo A. Ruiz-Bedoya, Elizabeth W. Tucker, Justin M. Luu, Dustin A. Dikeman, Wojciech G. Lesniak, Daniel P. Holt, Robert F. Dannals, Lloyd S. Miller, Steven P. Rowe, David M. Wilson, Sanjay K. Jain
Publikováno v:
JCI Insight, Vol 7, Iss 1 (2022)
Tools for noninvasive detection of bacterial pathogens are needed but are not currently available for clinical use. We have previously shown that para-aminobenzoic acid (PABA) rapidly accumulates in a wide range of pathogenic bacteria, motivating the
Externí odkaz:
https://doaj.org/article/5177739448e9442882f49a5d260f8ffe
Autor:
Jacob Ziontz, Murat Bilgel, Andrea T. Shafer, Abhay Moghekar, Wendy Elkins, Jessica Helphrey, Gabriela Gomez, Danielle June, Michael A. McDonald, Robert F. Dannals, Babak Behnam Azad, Luigi Ferrucci, Dean F. Wong, Susan M. Resnick
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 637-645 (2019)
Abstract Introduction Tau pathology, a hallmark of Alzheimer's disease, is observed in the brains of virtually all individuals over 70 years. Methods Using 18F‐AV‐1451 (18F‐flortaucipir) positron emission tomography, we evaluated tau pathology
Externí odkaz:
https://doaj.org/article/c72b594430654196b0394bb5b1f54f3f
Autor:
Farina J. Mahmud, Yong Du, Elizabeth Greif, Thomas Boucher, Robert F. Dannals, William B. Mathews, Martin G. Pomper, Polina Sysa-Shah, Kelly A. Metcalf Pate, Claire Lyons, Bess Carlson, Maria Chacona, Amanda M. Brown
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-3 (2020)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/bddb24d408874de9b1eac7b7ad35dc84
Autor:
Jennifer M. Coughlin, Ting Yang, Alison W. Rebman, Kathleen T. Bechtold, Yong Du, William B. Mathews, Wojciech G. Lesniak, Erica A. Mihm, Sarah M. Frey, Erica S. Marshall, Hailey B. Rosenthal, Tristan A. Reekie, Michael Kassiou, Robert F. Dannals, Mark J. Soloski, John N. Aucott, Martin G. Pomper
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-7 (2018)
Abstract The pathophysiology of post-treatment Lyme disease syndrome (PTLDS) may be linked to overactive immunity including aberrant activity of the brain’s resident immune cells, microglia. Here we used [11C]DPA-713 and positron emission tomograph
Externí odkaz:
https://doaj.org/article/6440ab2b9d39459594a7de8503d17d43