Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Robert Eugene Hormann"'
Publikováno v:
FEBS Journal. 274:5669-5689
Regulated gene expression may substantially enhance gene therapy. Correlated with structural differences between insect ecdysteroids and mammalian steroids, the ecdysteroids appear to have a benign pharmacology without adversely interfering with mamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d581173b765c702aba21df001d4ea9fe
https://doi.org/10.1111/j.1742-4658.2007.06089.x
https://doi.org/10.1111/j.1742-4658.2007.06089.x
Publikováno v:
Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2006, 247 (1-2), pp.64-72. ⟨10.1016/j.mce.2005.12.051⟩
Molecular and Cellular Endocrinology, Elsevier, 2006, 247 (1-2), pp.64-72. ⟨10.1016/j.mce.2005.12.051⟩
International audience; The ecdysteroids (Ec), invertebrate steroid hormones, elicit genomic but also non-genomic effects. By analogy to vertebrates, non-genomic responses towards Ec may be mediated not only by distinct membrane-integrated but also b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd7662cb612035d24b6c28e9cd325f6
https://doi.org/10.1016/j.mce.2005.12.051
https://doi.org/10.1016/j.mce.2005.12.051
Autor:
Angela Edwards, Damodhar R. Kethidi, Colin M. Tice, Michael Lawless, Mitch Polley, Mohan Basavaraju Kumar, Robert Eugene Hormann, Subba Reddy Palli, Philippa R.N. Wolohan, Martha A. Dipietro, David W. Potter, Howard Smith
Publikováno v:
Journal of Biological Chemistry. 279:27211-27218
The insect steroid hormone 20-hydroxyecdysone works through a ligand-activated nuclear receptor, the ecdysone receptor (EcR), which plays critical roles in insect development and reproduction. The EcR has been exploited to develop insecticides to con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98124d7c2c93838451df758c21d3dbe0
https://doi.org/10.1074/jbc.m403839200
https://doi.org/10.1074/jbc.m403839200
Autor:
Colin M. Tice, Caitlin K. Cavanaugh, Robert Eugene Hormann, Jessica A. Saggers, Christine S. Thompson, Jennifer L. Friz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1883-1886
Fifteen new α-acylaminoketones were prepared by four different routes in an initial effort to optimize the potency of these compounds as ecdysone agonists. The compounds were assayed in mammalian cells expressing the ecdysone receptors from Bombyx m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300537d5b2dd2ce3607a92156f855ca2
https://doi.org/10.1016/s0960-894x(03)00315-9
https://doi.org/10.1016/s0960-894x(03)00315-9
Publikováno v:
Vitamins and hormones
Vitamins and hormones, 2005, 73, pp.59-100. ⟨10.1016/S0083-6729(05)73003-X⟩
Vitamins and hormones, Elsevier, 2005, 73, pp.59-100. ⟨10.1016/S0083-6729(05)73003-X⟩
Vitamins and hormones, 2005, 73, pp.59-100. ⟨10.1016/S0083-6729(05)73003-X⟩
Vitamins and hormones, Elsevier, 2005, 73, pp.59-100. ⟨10.1016/S0083-6729(05)73003-X⟩
International audience; This chapter summarizes the present knowledge on the ecdysteroid receptor (EcR) structure and function with special emphasis on those aspects that are relevant for gene switch applications, and describes gene switch technology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7657495907b12c15a0587db889e2fb92
https://pubmed.ncbi.nlm.nih.gov/16399408
https://pubmed.ncbi.nlm.nih.gov/16399408
Autor:
Christine S. Thompson, Javier Garcia, Fernando Albericio, Enrique Luis Michelotti, Ernesto Nicolás, Robert Eugene Hormann, Caitlin K. Cavanaugh, Colin M. Tice, Jennifer L. Friz
Publikováno v:
ChemInform. 34
A lead discovery library and a follow-up focused library of α-acylaminoketones were designed based on known dibenzoylhydrazine ecdysone agonists, including GS ™ –E. The compounds were assayed in mammalian cells expressing the ecdysone receptor f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc79cfc407711a605af23d9e70b2129
https://doi.org/10.1002/chin.200320102
https://doi.org/10.1002/chin.200320102
Publikováno v:
Molecular and Cellular Endocrinology. 253:105
Fig. 2. Comparison between the differential surface representations of the ligand binding domains of the ecdysteroid receptor (EcR–LBD) of Heliothis virescens and of the human Vitamin D receptor (VDR–LBD). (a) The surfaces of EcR–LBD co-crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84d7ccf170e418316682d7e68b0f0fb0
https://doi.org/10.1016/j.mce.2006.04.009
https://doi.org/10.1016/j.mce.2006.04.009