Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

Autor: Matthias Kettwig, Katharina Ternka, Kristin Wendland, Dennis Manfred Krüger, Silvia Zampar, Charlotte Schob, Jonas Franz, Abhishek Aich, Anne Winkler, M. Sadman Sakib, Lalit Kaurani, Robert Epple, Hauke B. Werner, Samy Hakroush, Julia Kitz, Marco Prinz, Eva Bartok, Gunther Hartmann, Simone Schröder, Peter Rehling, Marco Henneke, Susann Boretius, A. Alia, Oliver Wirths, Andre Fischer, Christine Stadelmann, Stefan Nessler, Jutta Gärtner

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Studies on interferon-driven brain pathology have so far been hampered by the lack of appropriate animal models. Here the authors characterize RNASET2-deficient mice and show that neuroinflammation and brain atrophy are IFNAR1-dependent.

Externí odkaz: https://doaj.org/article/bd1fa646273840d68762f26fc8a37047

Supplementary Table 1 from EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor

Autor: Shailaja Kasibhatla, Steven Bender, Jennifer Harris, Peter McNamara, Pierre-Yves Michellys, Jeffrey A. Engelman, Nuzhat Pathan, Thomas H. Marsilje, Robert Epple, Matthew McNeill, Jordi Barretina, Gerald Lelais, Badry Bursulaya, Michael DiDonato, Eric Murphy, Debbie Liao, Carlotta Costa, Jennifer Anderson, Chun Li, Elizabeth L. Lockerman, AnneMarie Culazzo Pferdekamper, Mei-Ting Vaillancourt, Noelito Timple, Celin Tompkins, Matthew J. Niederst, Mari Manuia, Jie Li, Jose Juarez, Yong Jia

This file contains the supplementary Table S1 that describes the characteristics and anti-proliferative activities of EGF816 on a number of patient-derived cell lines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b02199c09204ac63e8515f8c075e07b
https://doi.org/10.1158/0008-5472.22409400

Supplementary Figures 1 through 5 from EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor

Autor: Shailaja Kasibhatla, Steven Bender, Jennifer Harris, Peter McNamara, Pierre-Yves Michellys, Jeffrey A. Engelman, Nuzhat Pathan, Thomas H. Marsilje, Robert Epple, Matthew McNeill, Jordi Barretina, Gerald Lelais, Badry Bursulaya, Michael DiDonato, Eric Murphy, Debbie Liao, Carlotta Costa, Jennifer Anderson, Chun Li, Elizabeth L. Lockerman, AnneMarie Culazzo Pferdekamper, Mei-Ting Vaillancourt, Noelito Timple, Celin Tompkins, Matthew J. Niederst, Mari Manuia, Jie Li, Jose Juarez, Yong Jia

This file shows the Supplementary figures. Figure S1 shows the chemical structure of EGF816 and its binding to EGFR T790M mutant. Figure S2 shows the tolerability of EGF816 in the in vivo xenograft models. Figure S3 shows the in vivo PK and PD after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081ab8464515db1aff3c0ba30b59f5d9
https://doi.org/10.1158/0008-5472.22409406.v1

Conserved reduction of m6A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts

Autor: Ricardo Castro-Hernández, Tea Berulava, Maria Metelova, Robert Epple, Tonatiuh Peña Centeno, Julia Richter, Lalit Kaurani, Ranjit Pradhan, M. Sadman Sakib, Susanne Burkhardt, Momchil Ninov, Katherine E. Bohnsack, Markus T. Bohnsack, Ivana Delalle, Andre Fischer

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 120(9), e2204933120 (2023). doi:10.1073/pnas.2204933120
Proceedings of the National Academy of Sciences of the United States of America

N 6 -methyladenosine (m 6 A) regulates mRNA metabolism. While it has been implicated in the development of the mammalian brain and in cognition, the role of m 6 A in synaptic plasticity, especially during cognitive decline, is not fully understood. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c930e6d735bc673ed9753105dea4b90
https://pub.dzne.de/record/255495

Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

Autor: Anne Winkler, Jonas Franz, Marco Henneke, Andre Fischer, Peter Rehling, A. Alia, Abhishek Aich, Hauke B. Werner, Simone Schröder, Samy Hakroush, Eva Bartok, Katharina Ternka, Charlotte Schob, Julia Kitz, Susann Boretius, Dennis M. Krüger, Robert Epple, M. Sadman Sakib, Silvia Zampar, Gunther Hartmann, Matthias Kettwig, Lalit Kaurani, Stefan Nessler, Kristin Wendland, Oliver Wirths, Jutta Gärtner, Marco Prinz, Christine Stadelmann

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications 12(1), 6530 (2021). doi:10.1038/s41467-021-26880-x
Nature Communications, 12. Springer Science and Business Media LLC
Nature Communications

Infantile-onset RNaseT2 deficient leukoencephalopathy is characterised by cystic brain lesions, multifocal white matter alterations, cerebral atrophy, and severe psychomotor impairment. The phenotype is similar to congenital cytomegalovirus brain inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a39641743424497b9aa6ec04706ed2
https://doaj.org/article/bd1fa646273840d68762f26fc8a37047