Výsledky vyhledávání - "Robert Elsby"

Akademický článek

Mechanistic in vitro studies indicate that the clinical drug–drug interactions between protease inhibitors and rosuvastatin are driven by inhibition of intestinal BCRP and hepatic OATP1B1 with minimal contribution from OATP1B3, NTCP and OAT3

Autor: Robert Elsby, Hannah Coghlan, Jacob Edgerton, David Hodgson, Samuel Outteridge, Hayley Atkinson

Publikováno v: Pharmacology Research & Perspectives, Vol 11, Iss 2, Pp n/a-n/a (2023)

Abstract Previous use of a mechanistic static model to accurately quantify the increased rosuvastatin exposure due to drug–drug interaction (DDI) with coadministered atazanavir underpredicted the magnitude of area under the plasma concentration–t

Externí odkaz: https://doaj.org/article/075d225063564397af4a6d25201f4d17

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Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure

Autor: Dominic Surry, Paul D. Martin, Robert Elsby, Pradeep Sharma, Katherine Fenner

Publikováno v: Drug Metabolism and Disposition. 44:398-408

The intestinal efflux transporter breast cancer resistance protein (BCRP) restricts the absorption of rosuvastatin. Of the transporters important to rosuvastatin disposition, fostamatinib inhibited BCRP (IC50 = 50 nM) and organic anion-transporting p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04164c4908a5d7969ec3c8ad2660fc2a
https://doi.org/10.1124/dmd.115.066795

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Effects of Fostamatinib on the Pharmacokinetics of Digoxin (a P-Glycoprotein Substrate): Results From in Vitro and Phase I Clinical Studies

Autor: Robert Elsby, Michael Gillen, Muhammad Baluom, David Lau, Tim Mant, Paul D. Martin, David Millson, Stuart Oliver, Clive Brealey

Publikováno v: Clinical Therapeutics. 37:2811-2822

Purpose Fostamatinib, a spleen tyrosine kinase inhibitor and prodrug of the active metabolite R406, is being developed as an anti-inflammatory drug for several indications for which polypharmacy is likely. Digoxin, indicated for congestive cardiac fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39ab6837328faad573fbe22eed9c317
https://doi.org/10.1016/j.clinthera.2015.09.018

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Mechanistic In Vitro Studies Indicate that the Clinical Drug-Drug Interaction between Telithromycin and Simvastatin Acid Is Driven by Time-Dependent Inhibition of CYP3A4 with Minimal Effect on OATP1B1

Autor: Katie Plant, Philip J. Butler, Samuel Outteridge, Robert Elsby, Robert J. Riley, Catherine Pearson, Rachel Upcott Gill, Victoria Hare, Hannah Neal

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 47(1)

A previous attempt to accurately quantify the increased simvastatin acid exposure due to drug-drug interaction (DDI) with coadministered telithromycin, using a mechanistic static model, substantially underpredicted the magnitude of the area under the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3399849b32a1479fe51a97bc6e9d0c6b
https://pubmed.ncbi.nlm.nih.gov/30348903

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Impact of ABCG2 and SLCO1B1 polymorphisms on pharmacokinetics of rosuvastatin, atorvastatin and simvastatin acid in Caucasian and Asian subjects: a class effect?

Autor: Helen Ambrose, Cheryl Wei, Yusong Chen, Rogelio Mosqueda-Garcia, Connie T. Azumaya, Robert Elsby, Bruce K. Birmingham, Sarah R. Bujac

Publikováno v: European Journal of Clinical Pharmacology. 71:341-355

Systemic exposure to rosuvastatin is approximately double that of Caucasians in Asian subjects. We investigated whether this pattern of increased exposure exists for other statins. Plasma exposure following single-dose rosuvastatin 20 mg, atorvastati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a741c6d90792966508f8f52852f3f2
https://doi.org/10.1007/s00228-014-1801-z

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Rosuvastatin pharmacokinetics and pharmacogenetics in Caucasian and Asian subjects residing in the United States

Autor: Sarah R. Bujac, Robert Elsby, Bruce K. Birmingham, Connie T. Azumaya, Julie Zalikowski, Yusong Chen, Kenneth T. Kim, Helen Ambrose

Publikováno v: European Journal of Clinical Pharmacology. 71:329-340

Systemic exposure to rosuvastatin in Asian subjects living in Japan or Singapore is approximately twice that observed in Caucasian subjects in Western countries or in Singapore. This study was conducted to determine whether pharmacokinetic difference

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380902d27bcaf211e5a6909924fba44c
https://doi.org/10.1007/s00228-014-1800-0

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