Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Robert E. Schwartz"'
Autor:
Sonal Kumar, Arpan Mohanty, Parvez Mantry, Robert E. Schwartz, Madeleine Haff, George Therapondos, Mazen Noureddin, Douglas Dieterich, Nigel Girgrah, Kristi Cohn, Mohanish Savanth, Michael Fuchs
Publikováno v:
BMC Primary Care, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to as nonalcoholic fatty liver disease, impacts 30% of the global population. This educational pilot focused on the role primary care providers ma
Externí odkaz:
https://doaj.org/article/13d7026a37a945ca839be69c47a57159
Autor:
J. Tyson McDonald, JangKeun Kim, Lily Farmerie, Meghan L. Johnson, Nidia S. Trovao, Shehbeel Arif, Keith Siew, Sergey Tsoy, Yaron Bram, Jiwoon Park, Eliah Overbey, Krista Ryon, Jeffrey Haltom, Urminder Singh, Francisco J. Enguita, Victoria Zaksas, Joseph W. Guarnieri, Michael Topper, Douglas C. Wallace, Cem Meydan, Stephen Baylin, Robert Meller, Masafumi Muratani, D. Marshall Porterfield, Brett Kaufman, Marcelo A. Mori, Stephen B. Walsh, Dominique Sigaudo-Roussel, Saida Mebarek, Massimo Bottini, Christophe A. Marquette, Eve Syrkin Wurtele, Robert E. Schwartz, Diego Galeano, Christopher E. Mason, Peter Grabham, Afshin Beheshti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Our previous research revealed a key microRNA signature that is associated with spaceflight that can be used as a biomarker and to develop countermeasure treatments to mitigate the damage caused by space radiation. Here, we expand on this wo
Externí odkaz:
https://doaj.org/article/0649faa161fd46558b42240dde0a9327
Autor:
Yongzhen Liu, Thomas R. Cafiero, Debby Park, Abhishek Biswas, Benjamin Y. Winer, Cheul H. Cho, Yaron Bram, Vasuretha Chandar, Aoife K. O’ Connell, Hans P. Gertje, Nicholas Crossland, Robert E. Schwartz, Alexander Ploss
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Hepatitis B virus (HBV) only infects humans and chimpanzees, posing major challenges for modeling HBV infection and chronic viral hepatitis. The major barrier in establishing HBV infection in non-human primates lies at incompatibilities betw
Externí odkaz:
https://doaj.org/article/715209dd3f1c45be80f29128c56a1eea
Autor:
Ting-Yu Lin, Shakti Ramsamooj, Tiffany Perrier, Katarina Liberatore, Louise Lantier, Neil Vasan, Kannan Karukurichi, Seo-Kyoung Hwang, Edward A. Kesicki, Edward R. Kastenhuber, Thorsten Wiederhold, Tomer M. Yaron, Emily M. Huntsman, Mengmeng Zhu, Yilun Ma, Marcia N. Paddock, Guoan Zhang, Benjamin D. Hopkins, Owen McGuinness, Robert E. Schwartz, Baran A. Ersoy, Lewis C. Cantley, Jared L. Johnson, Marcus D. Goncalves
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113535- (2023)
Summary: The phosphoinositide 3-kinase p110α is an essential mediator of insulin signaling and glucose homeostasis. We interrogated the human serine, threonine, and tyrosine kinome to search for novel regulators of p110α and found that the Hippo ki
Externí odkaz:
https://doaj.org/article/a5e7df93b0a7464587f421f871a959bf
Autor:
Savannah L. Herbek, Marie C. Smithgall, Elisabeth A. Murphy, Robert E. Schwartz, Shuibing Chen, Laura E. Riley, Heidi Stuhlmann, Yawei J. Yang, Ria Goswami
Publikováno v:
Reproductive Medicine, Vol 3, Iss 4, Pp 303-319 (2022)
Pregnancy is a period of elevated risk for viral disease severity, resulting in serious health consequences for both the mother and the fetus; yet antiviral drugs lack comprehensive safety and efficacy data for use among pregnant women. In fact, preg
Externí odkaz:
https://doaj.org/article/6e7cb1bf898448a0ba232c52cf01aaa7
Autor:
Rodrigo R. R. Duarte, Dennis C. Copertino, Luis P. Iñiguez, Jez L. Marston, Yaron Bram, Yuling Han, Robert E. Schwartz, Shuibing Chen, Douglas F. Nixon, Timothy R. Powell
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-11 (2021)
Abstract Background Vaccination programs have been launched worldwide to halt the spread of COVID-19. However, the identification of existing, safe compounds with combined treatment and prophylactic properties would be beneficial to individuals who a
Externí odkaz:
https://doaj.org/article/bce76190279a4c49ad83ba37633ed9c4
Autor:
Yongzhen Liu, Debby Park, Thomas R. Cafiero, Yaron Bram, Vasuretha Chandar, Anna Tseng, Hans P. Gertje, Nicholas A. Crossland, Lishan Su, Robert E. Schwartz, Alexander Ploss
Publikováno v:
JHEP Reports, Vol 4, Iss 9, Pp 100535- (2022)
Background & Aims: HBV exhibits wide genetic diversity with at least 9 genotypes (GTs), which differ in terms of prevalence, geographic distribution, natural history, disease progression, and treatment outcome. However, differences in HBV replicative
Externí odkaz:
https://doaj.org/article/1554fc7886654cae9e56bd1c430ac1fc
Autor:
Daniel Butler, Christopher Mozsary, Cem Meydan, Jonathan Foox, Joel Rosiene, Alon Shaiber, David Danko, Ebrahim Afshinnekoo, Matthew MacKay, Fritz J. Sedlazeck, Nikolay A. Ivanov, Maria Sierra, Diana Pohle, Michael Zietz, Undina Gisladottir, Vijendra Ramlall, Evan T. Sholle, Edward J. Schenck, Craig D. Westover, Ciaran Hassan, Krista Ryon, Benjamin Young, Chandrima Bhattacharya, Dianna L. Ng, Andrea C. Granados, Yale A. Santos, Venice Servellita, Scot Federman, Phyllis Ruggiero, Arkarachai Fungtammasan, Chen-Shan Chin, Nathaniel M. Pearson, Bradley W. Langhorst, Nathan A. Tanner, Youngmi Kim, Jason W. Reeves, Tyler D. Hether, Sarah E. Warren, Michael Bailey, Justyna Gawrys, Dmitry Meleshko, Dong Xu, Mara Couto-Rodriguez, Dorottya Nagy-Szakal, Joseph Barrows, Heather Wells, Niamh B. O’Hara, Jeffrey A. Rosenfeld, Ying Chen, Peter A. D. Steel, Amos J. Shemesh, Jenny Xiang, Jean Thierry-Mieg, Danielle Thierry-Mieg, Angelika Iftner, Daniela Bezdan, Elizabeth Sanchez, Thomas R. Campion, John Sipley, Lin Cong, Arryn Craney, Priya Velu, Ari M. Melnick, Sagi Shapira, Iman Hajirasouliha, Alain Borczuk, Thomas Iftner, Mirella Salvatore, Massimo Loda, Lars F. Westblade, Melissa Cushing, Shixiu Wu, Shawn Levy, Charles Chiu, Robert E. Schwartz, Nicholas Tatonetti, Hanna Rennert, Marcin Imielinski, Christopher E. Mason
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Here, using clinical samples and autopsy tissues, the authors combine fast-colorimetric test (LAMP) for SARS-CoV-2 infection and large-scale shotgun metatranscriptomics for host, viral, and microbial profiling and provide a map of the viral genetic f
Externí odkaz:
https://doaj.org/article/e049d27579f84e2b9f12b7b11bc7c436
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract We report here the use of a nanofibrous hydrogel as a 3D scaffold for the culture and maintenance of functional primary human hepatocytes. The system is based on the cooperative assembly of a fiber-forming peptide component, fluorenylmethylo
Externí odkaz:
https://doaj.org/article/a265405ebb39499f8c65ae9cd5b1da6b
Autor:
Lissenya B. Argueta, Lauretta A. Lacko, Yaron Bram, Takuya Tada, Lucia Carrau, André Figueiredo Rendeiro, Tuo Zhang, Skyler Uhl, Brienne C. Lubor, Vasuretha Chandar, Cristianel Gil, Wei Zhang, Brittany J. Dodson, Jeroen Bastiaans, Malavika Prabhu, Sean Houghton, David Redmond, Christine M. Salvatore, Yawei J. Yang, Olivier Elemento, Rebecca N. Baergen, Benjamin R. tenOever, Nathaniel R. Landau, Shuibing Chen, Robert E. Schwartz, Heidi Stuhlmann
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104223- (2022)
Summary: The effect of SARS-CoV-2 infection on placental function is not well understood. Analysis of placentas from women who tested positive at delivery showed SARS-CoV-2 genomic and subgenomic RNA in 22 out of 52 placentas. Placentas from two moth
Externí odkaz:
https://doaj.org/article/10e8c8bb49714f07ba4f189eb87775e5