Zobrazeno 1 - 10
of 255
pro vyhledávání: '"Robert E. Kingston"'
Autor:
Jakub Mieczkowski, April Cook, Sarah K. Bowman, Britta Mueller, Burak H. Alver, Sharmistha Kundu, Aimee M. Deaton, Jennifer A. Urban, Erica Larschan, Peter J. Park, Robert E. Kingston, Michael Y. Tolstorukov
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nucleosome positioning and chromatin accessibility are important contributors to the regulation of gene expression. Here the authors describe a method that allows the simultaneous measurement of nucleosome occupancy and chromatin accessibility in the
Externí odkaz:
https://doaj.org/article/0238a8cab20c4061987b9392b7b9bc4e
Autor:
Ajazul H. Wani, Alistair N. Boettiger, Patrick Schorderet, Ayla Ergun, Christine Münger, Ruslan I. Sadreyev, Xiaowei Zhuang, Robert E. Kingston, Nicole J. Francis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Polycomb Group (PcG) proteins regulate gene expression and genome architecture. Using super-resolution microscopy and molecular simulations, Waniet al. describe the organization of PcG proteins into hundreds of nano-scale protein clusters and suggest
Externí odkaz:
https://doaj.org/article/bad9f905cda545d68fdd91a193c22c33
Autor:
Audrey Sporrij, Avik Choudhuri, Meera Prasad, Brejnev Muhire, Eva M. Fast, Margot E. Manning, Jodi D. Weiss, Michelle Koh, Song Yang, Robert E. Kingston, Michael Y. Tolstorukov, Hans Clevers, Leonard I. Zon
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Prostaglandin E2 (PGE 2 ) and 16,16-dimethyl-PGE 2 (dmPGE 2 ) are important regulators of hematopoietic stem and progenitor cell (HSPC) fate and offer potential to enhance stem cell therapies [C. Cutler et al. Blood 122 , 3074–3081(2013); W. Goessl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d0c0a7a4904b71bdda75c86c0a6bfe4
https://doi.org/10.1073/pnas.2220613120
https://doi.org/10.1073/pnas.2220613120
Autor:
Yu Wang, Vinay V. Eapen, Athanasios Kournoutis, Angelique Onorati, Xianting Li, Xiaoting Zhou, Murat Cetinbas, Lu Wang, Jihe Liu, Corey Bretz, Zhuo Zhou, Shannan J. Ho Sui, Srinivas Vinod Saladi, Ruslan I. Sadreyev, Peter D. Adams, Robert E. Kingston, Zhenyu Yue, Terje Johansen, Zhixun Dou
Macroautophagy (hereafter referred to as autophagy) degrades a variety of cellular components. A poorly understood area is autophagic degradation of nuclear substrates, or “nuclear autophagy”. It remains unclear what can be degraded by autophagy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a364478f98e99194046bd74d635541c0
https://doi.org/10.1101/2022.10.04.510822
https://doi.org/10.1101/2022.10.04.510822
Autor:
Audrey Sporrij, Meera Prasad, Brejnev Muhire, Eva M. Fast, Margot E. Manning, Avik Choudhuri, Jodi D. Weiss, Michelle Koh, Song Yang, Robert E. Kingston, Michael Y. Tolstorukov, Hans Clevers, Leonard I. Zon
Prostaglandin E2 (PGE2) and 16,16-dimethyl-PGE2 (dmPGE2) are important regulators of hematopoietic stem and progenitor cell (HSPC) fate and offer potential to enhance stem cell therapies1,2. The mechanism of gene regulation in response to dmPGE2 is p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14270f12b9a6547dffe5b56d7aec5043
https://doi.org/10.1101/2022.09.12.507565
https://doi.org/10.1101/2022.09.12.507565
SummaryPolycomb group (PcG) proteins maintain the repressed state of lineage-inappropriate genes and are therefore essential for embryonic development and adult tissue homeostasis. One critical function of PcG complexes is modulating chromatin struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e4bd4dfa9d5de8ba1f36ee96644e3ca
https://doi.org/10.1101/2022.08.25.505322
https://doi.org/10.1101/2022.08.25.505322
Autor:
Aimee M Deaton, Mariluz Gómez-Rodríguez, Jakub Mieczkowski, Michael Y Tolstorukov, Sharmistha Kundu, Ruslan I Sadreyev, Lars ET Jansen, Robert E Kingston
Publikováno v:
eLife, Vol 5 (2016)
The organization of DNA into chromatin is dynamic; nucleosomes are frequently displaced to facilitate the ability of regulatory proteins to access specific DNA elements. To gain insight into nucleosome dynamics, and to follow how dynamics change duri
Externí odkaz:
https://doaj.org/article/ece94af87bd149a69da91605cfc44b1a
Autor:
Rosanna Weksberg, Courtney Kiss, Marta Szybowska, Nina Ekhilevitch, Irina Anselm, David A. Sweetser, Michael Marble, Kristin Lindstrom, Cara Forster, Haley Streff, Renata C. Gallagher, John Pappas, Jessica Nance, Patricia G Wheeler, Melissa A. Walker, Grace Yoon, Carl E. Stafstrom, Weiyi Mu, Mary Kay Koenig, Wei Wang, Jane Juusola, Lauren C. Briere, Eric Muller, Julie S. Cohen, E. Hallie Andrew, Frances A. High, Cheryl Cytrynbaum, Jamie L. Fraser, Joel B. Krier, Hannah Meddaugh, Ali Fatemi, Robert E. Kingston, Kristin W. Barañano, Bridget Ostrem, Maria J. Guillen Sacoto, Ellen Moran, Marvin R. Natowicz, Karin Weiss, Erin Torti, Iva A. Tchasovnikarova, William J. Craigen, Cara Inglese, Andrea Guerin, Matthew J. Elrick, Devon Haynes, Chantal F. Morel, Adam L. Numis
Publikováno v:
Am J Hum Genet
MORC2 encodes an ATPase that plays a role in chromatin remodeling, DNA repair, and transcriptional regulation. Heterozygous variants in MORC2 have been reported in individuals with autosomal-dominant Charcot-Marie-Tooth disease type 2Z and spinal mus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe48c69116fc39c7b9900e63ac29144
https://doi.org/10.1016/j.ajhg.2020.06.013
https://doi.org/10.1016/j.ajhg.2020.06.013
Autor:
Adfar Amin, Sangram Kadam, Jakub Mieczkowski, Ikhlak Ahmed, Younus A Bhat, Fouziya Shah, Michael Y Tolstorukov, Robert E Kingston, Ranjith Padinhateeri, Ajazul H Wani
Publikováno v:
Life Science Alliance. 6:e202201768
Chromatin attains its three-dimensional (3D) conformation by establishing contacts between different noncontiguous regions. Sterile Alpha Motif (SAM)–mediated polymerization of the polyhomeotic (PH) protein regulates subnuclear clustering of Polyco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ac816421dbc2667fb9d8e859c798db4
https://doi.org/10.26508/lsa.202201768
https://doi.org/10.26508/lsa.202201768
Publikováno v:
Mol Cell
Genetically encoded biosensors are powerful tools to monitor cellular behavior, but the difficulty in generating appropriate reporters for chromatin factors hampers our ability to dissect epigenetic pathways. Here, we present TRACE (transgene reporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904f531c5f40a9fe994c93b658c55cdc