Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Robert E. Humphreys"'
Autor:
Minzhen Xu, John K. Young, George E. Wright, Donald J. Nelson, Frank Marí, Joseph Gambino, Nikki M. Clemente, Robert E. Humphreys, James Michael Walker Stattel
Publikováno v:
The Journal of Peptide Research. 50:122-131
The 1H NMR-determined structure and dynamics of a synthetic, amphiphilic alpha-helical peptide, PH-1.0 (LYQELQKLTQTLK), and several homologs were compared in 50% trifluoroethanol-d2 (TFE-d2)/H20 and in sodium dodecyl-d25 sulfate (SDS-d25) micelles. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90c5c72caf3f12487d94c342f34697fb
https://doi.org/10.1111/j.1399-3011.1997.tb01177.x
https://doi.org/10.1111/j.1399-3011.1997.tb01177.x
Autor:
Minzhen Xu, Xueqing Lu, Robert E. Humphreys, Shuzhen Wu, Catherine E. Blackwell, Eric von Hofe
Publikováno v:
Immunology. 120:207-216
Summary One function of the major histocompatibility complex (MHC) class II-associated invariant chain (Ii) is to prevent MHC class II molecules from binding endogenously generated antigenic epitopes. Ii inhibition leads to MHC class II presentation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4db5e1d6473fd8539e56b7b8a1d11e
https://doi.org/10.1111/j.1365-2567.2006.02492.x
https://doi.org/10.1111/j.1365-2567.2006.02492.x
Autor:
Minzhen Xu, Nikoletta L. Kallinteris, Eric von Hofe, Robert E. Humphreys, Catherine E. Blackwell, Xueqing Lu
Publikováno v:
Expert Opinion on Biological Therapy. 6:1311-1321
Life-threatening diseases, such as cancer and pandemic influenza, demand new efforts towards effective vaccine design. Peptides represent a simple, safe and adaptable basis for vaccine development; however, the potency of peptide vaccines is insuffic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4614eabf6fbc3d98d405b73e8c7744c
https://doi.org/10.1517/14712598.6.12.1311
https://doi.org/10.1517/14712598.6.12.1311
Autor:
Angelos D. Gritzapis, Theodoros Pavlis, Eric von Hofe, Nikoletta L. Kallinteris, Nectaria N. Sotiriadou, Constantin N. Baxevanis, Ioannis F. Voutsas, Michael Papamichail, Robert E. Humphreys, Sonia A. Perez
Publikováno v:
Cancer Immunology, Immunotherapy. 56:601-613
We have demonstrated that coupling an immunoregulatory segment of the MHC class II-associated invariant chain (Ii), the Ii-Key peptide, to a promiscuous MHC class II epitope significantly enhances its presentation to CD4+ T cells. Here, a series of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::038b8fd69920c8a7e7b1efb0136e394b
https://doi.org/10.1007/s00262-006-0213-z
https://doi.org/10.1007/s00262-006-0213-z
Autor:
Nikoletta L. Kallinteris, Joseph V Gulfo, Yu Li, Minzhen Xu, Shuzhen Wu, Robert E. Humphreys, Hongliang Hu, Xueqing Lu
Publikováno v:
Vaccine. 21:4128-4132
The Ii-Key/MHC class II epitope hybrid acts on MHC class II molecules to facilitate replacement of antigenic peptides with the epitope tethered to the Ii-Key motif. Hybrid peptides linking an immunoregulatory segment of the Ii protein (Ii-Key peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d14726277e4159a70f4d3d91feb462
https://doi.org/10.1016/s0264-410x(03)00493-6
https://doi.org/10.1016/s0264-410x(03)00493-6
Autor:
Xueqing Lu, Gilda G. Hillman, Robert E. Humphreys, Minzhen Xu, Yu Li, Nikoletta L. Kallinteris, Joseph V Gulfo, Jizhi Li, Shuzhen Wu, Zhong Jiang
Publikováno v:
Cancer Immunology, Immunotherapy. 52:592-598
A potent antitumor CD4(+) T-helper cell immune response is created by inducing tumor cells in vivo to a MHC class II(+)/Ii(- )phenotype. MHC class II and Ii molecules were induced in tumor cells in situ following tumor injection of a plasmid containi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69defa9bef955666997bdf515b1915eb
https://doi.org/10.1007/s00262-003-0404-9
https://doi.org/10.1007/s00262-003-0404-9
Autor:
Robert E. Humphreys, Birgit Drabner, Susanne Hartmann, Jens Schneider-Mergener, Richard Lucius, Ulrich Reineke
Publikováno v:
Vaccine. 20:3685-3694
T helper cell-recognized epitopes were determined in chitinase of Onchocerca volvulus, a vaccine candidate protein. The proliferation of splenic T cells of mice immunized with recombinant protein was tested with a library of chitinase-peptides of 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c07f9a5f8b7a90750b4f1faea02a229
https://doi.org/10.1016/s0264-410x(02)00395-x
https://doi.org/10.1016/s0264-410x(02)00395-x
Publikováno v:
Scandinavian Journal of Immunology. 54:39-44
The discovery of the interactions of the 'Ii-Key' segment of the Ii protein with the major histocmpatibility complex (MHC) Class II allosteric site, which is adjacent to the antigenic peptide-binding site, creates therapeutic opportunities by regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5839bbee7b27bf567fb2b84ede4a01de
https://doi.org/10.1046/j.1365-3083.2001.00964.x
https://doi.org/10.1046/j.1365-3083.2001.00964.x
Publikováno v:
Trends in Biotechnology. 18:167-172
An effective cancer-cell vaccine is created by expressing major-histocompatibility-complex (MHC) class II molecules without the invariant chain protein (Ii) that normally blocks the antigenic-peptide-binding site of MHC class II molecules at their sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02594faf7d4859244195026652b0e4ad
https://doi.org/10.1016/s0167-7799(00)01421-9
https://doi.org/10.1016/s0167-7799(00)01421-9
Autor:
Sharlene Adams, Robert E. Humphreys
Publikováno v:
European Journal of Immunology. 25:1693-1702
Two soluble invariant chain (Ii) peptides with overlapping sequences had contrasting effects on the presentation of antigenic peptides by murine Ad, Ak, Ed, and Ek major histocompatibility complex (MHC) class II molecules. Naturally produced class II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc73d93603a886e45d6f6adeab87c60c
https://doi.org/10.1002/eji.1830250632
https://doi.org/10.1002/eji.1830250632