Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Robert E. Emerson"'
Autor:
Horacio Cardenas, Fang Fang, Guanglong Jiang, Susan M. Perkins, Chi Zhang, Robert E. Emerson, George Hutchins, Harold N. Keer, Yunlong Liu, Daniela Matei, Kenneth Nephew
Publikováno v:
Epigenetics, Vol 16, Iss 11, Pp 1201-1216 (2021)
High-grade serous ovarian cancer (HGSOC) harbours aberrant epigenetic features, including DNA methylation. In this study we delineate pathways and networks altered by DNA methylation and associated with HGSOC initiation and progression to a platinum-
Externí odkaz:
https://doaj.org/article/ae8d07e5d9604a41bb9960295ddd78e5
Autor:
Olga Kim, Eun Young Park, David L Klinkebiel, Svetlana D Pack, Yong-Hyun Shin, Zied Abdullaev, Robert E Emerson, Donna M Coffey, Sun Young Kwon, Chad J Creighton, Sanghoon Kwon, Edmund C Chang, Theodore Chiang, Alexander N Yatsenko, Jeremy Chien, Dong-Joo Cheon, Yang Yang-Hartwich, Harikrishna Nakshatri, Kenneth P Nephew, Richard R Behringer, Facundo M Fernández, Chi-Heum Cho, Barbara Vanderhyden, Ronny Drapkin, Robert C Bast, Kathy D Miller, Adam R Karpf, Jaeyeon Kim
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008808 (2020)
Metastasis is responsible for 90% of human cancer mortality, yet it remains a challenge to model human cancer metastasis in vivo. Here we describe mouse models of high-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), the
Externí odkaz:
https://doaj.org/article/a0866ddae28348acb288e0a6cd580d54
Autor:
Mariana S. L. Praça, Xiyin Wang, Shannon M. Hawkins, Francesco J. DeMayo, John P. Lydon, Robert E. Emerson, Jillian R. H. Wendel
Publikováno v:
Am J Pathol
Oncogenic KRAS mutations are a common finding in endometrial cancers. Recent sequencing studies indicate that loss-of-function mutations in the ARID1A gene are enriched in gynecologic malignant tumors. However, neither of these genetic insults alone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97157bbf58ed9d17408871b3d01e970e
https://doi.org/10.1016/j.ajpath.2021.03.013
https://doi.org/10.1016/j.ajpath.2021.03.013
Publikováno v:
Cancers
Cancers, Vol 13, Iss 3821, p 3821 (2021)
Volume 13
Issue 15
Cancers, Vol 13, Iss 3821, p 3821 (2021)
Volume 13
Issue 15
Simple Summary Despite tremendous research efforts, epithelial ovarian cancer (EOC) remains one of the most difficult cancers to detect early and treat successfully for >5-year survival. We have recently shown that ZIP4, a zinc transporter, is a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81534f8fcad1ccdb245fc8f4be70ee4f
http://europepmc.org/articles/PMC8345154
http://europepmc.org/articles/PMC8345154
Autor:
Hsim Yee Chang, Robert E. Emerson, Xiaoyan Wang, Harvey M. Cramer, Kendra Curless, Shaobo Zhang, Liang Cheng, Melissa Randolph, Howard H. Wu, Shaoxiong Chen
Publikováno v:
Applied Immunohistochemistry & Molecular Morphology. 27:119-124
Objective: The aim of this study was to investigate epidermal growth factor receptor (EGFR) gene mutations and anaplastic lymphoma kinase (ALK) gene rearrangements using cytological specimens from the patients with a diagnosis of primary or metastati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60030e3648ed5014d56926233f54c4cb
https://doi.org/10.1097/pai.0000000000000701
https://doi.org/10.1097/pai.0000000000000701
Autor:
Mariana S. L. Praça, Jillian R. H. Wendel, Shannon M. Hawkins, Francesco J. DeMayo, Xiyin Wang, John P. Lydon, Robert E. Emerson
Recent sequencing studies showed that loss-of-function mutations in ARID1A (AT-rich interactive domain 1a) were enriched in gynecologic malignancies. However, multiple mouse models with deletion of Arid1a did not exhibit gynecologic malignancy. Oncog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72ab42702e570bea0dedd27eac90544e
https://doi.org/10.1101/2020.12.15.422959
https://doi.org/10.1101/2020.12.15.422959
Publikováno v:
Cancers
Volume 12
Issue 12
Cancers, Vol 12, Iss 3692, p 3692 (2020)
Volume 12
Issue 12
Cancers, Vol 12, Iss 3692, p 3692 (2020)
Simple Summary Ovarian cancer is the most deadly gynecologic cancer. The treatment options for ovarian cancer, and for the recurrent cancer in particular, are limited. One of the major obstacles is the presence of drug-resistant cancer stem cells. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f274cbb3ac1e7f27b88f7934a3e527b0
Autor:
Daniela Matei, Fang Fang, Kenneth P. Nephew, Harold N. Keer, Guanglong Jiang, Robert E. Emerson, Susan M. Perkins, Horacio Cardenas, Chi Zhang, George Hutchins, Yunlong Liu
Publikováno v:
Epigenetics
High-grade serous ovarian cancer (HGSOC) harbours aberrant epigenetic features, including DNA methylation. In this study we delineate pathways and networks altered by DNA methylation and associated with HGSOC initiation and progression to a platinum-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b57b7bd7e85cf2f2d404fec2748a71c
https://pubmed.ncbi.nlm.nih.gov/33289590
https://pubmed.ncbi.nlm.nih.gov/33289590
Autor:
Donna Coffey, Kenneth P. Nephew, John P. Lydon, Andrew K. Godwin, Shannon M. Hawkins, Robert E. Emerson, Kathy D. Miller, Francesco J. DeMayo, Lawrence A. Quilliam, Martin Widschwendter, Anil K. Sood, Chi Heum Cho, Olga Kim, Adam R. Karpf, Jaeyeon Kim, S. Shin, Robert C. Bast, Yong-Hyun Shin, Eun Young Park, Sun Young Kwon, Facundo M. Fernández, Dong-Joo Cheon
Publikováno v:
Proc Natl Acad Sci U S A
PNAS
PNAS
SignificanceWhy women carrying a pathogenic germlineBRCA1mutation are predisposed to ovarian and breast cancer remains elusive. This study points to ovarian progesterone as a culprit. Generally,BRCA1-mutation carriers exhibit high yet individually va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6329d59a8fdd1cea8ebd6f4b537d481a
https://europepmc.org/articles/PMC7749341/
https://europepmc.org/articles/PMC7749341/
Autor:
Russell Broaddus, Robert E. Emerson, Shannon M. Hawkins, Jillian R. H. Wendel, John P. Lydon, Francesco J. DeMayo, Chad J. Creighton, Aaron Buechlein, Xiyin Wang, Douglas B. Rusch
Publikováno v:
Oncogene
Endometrial cancer remains the most common gynecological malignancy in the United States. While the loss of the tumor suppressor, PTEN (phosphatase and tensin homolog), is well studied in endometrial cancer, recent studies suggest that DICER1, the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de94142931b0a6b8f30d3fd7a7fcb519
https://pubmed.ncbi.nlm.nih.gov/32843721
https://pubmed.ncbi.nlm.nih.gov/32843721