Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Robert E. Drolet"'
Autor:
Mali Cosden, Sarah Jinn, Lihang Yao, Cheryl A. Gretzula, Monika Kandebo, Dawn Toolan, Nathan G. Hatcher, Lei Ma, Wei Lemaire, Gregory C. Adam, Christine Burlein, Christina Minnick, Rose Flick, Marla L. Watt, James Mulhearn, Mark Fraley, Robert E. Drolet, Jacob N. Marcus, Sean M. Smith
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105507- (2021)
Mutations in the lysosomal enzyme glucocerebrosidase (GCase, GBA1 gene) are the most common genetic risk factor for developing Parkinson's disease (PD). GCase metabolizes the glycosphingolipids glucosylceramide (GlcCer) and glucosylsphingosine (GlcSp
Externí odkaz:
https://doaj.org/article/5bb119e476704557a1fe920f9ef43979
Publikováno v:
Neurobiology of Disease, Vol 36, Iss 1, Pp 96-102 (2009)
Gastrointestinal disorders, particularly severe constipation and delayed gastric emptying, are core symptoms of Parkinson's disease that affect most patients. However, the neuropathological substrate and physiological basis for this dysfunction are p
Externí odkaz:
https://doaj.org/article/2f41af552f1a4027a459a33302118ac1
Autor:
Jason R. Cannon, Victor Tapias, Hye Mee Na, Anthony S. Honick, Robert E. Drolet, J. Timothy Greenamyre
Publikováno v:
Neurobiology of Disease, Vol 34, Iss 2, Pp 279-290 (2009)
The systemic rotenone model of Parkinson's disease (PD) accurately replicates many aspects of the pathology of human PD and has provided insights into the pathogenesis of PD. The major limitation of the rotenone model has been its variability, both i
Externí odkaz:
https://doaj.org/article/e3f9d1d256e44950b12893974ac97549
Autor:
Anthony J. Roecker, Kathy M. Schirripa, H. Marie Loughran, Ling Tong, Tao Liang, Kerry L. Fillgrove, Yuhsin Kuo, Kelly Bleasby, Hannah Collier, Michael D. Altman, Melissa C. Ford, Robert E. Drolet, Mali Cosden, Sarah Jinn, Nathan G. Hatcher, Lihang Yao, Monika Kandebo, Joshua D. Vardigan, Rosemarie B. Flick, Xiaomei Liu, Christina Minnick, Laura A. Price, Marla L. Watt, Wei Lemaire, Christine Burlein, Gregory C. Adam, Lauren A. Austin, Jacob N. Marcus, Sean M. Smith, Mark E. Fraley
Publikováno v:
ACS Medicinal Chemistry Letters. 14:146-155
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69a75f2713f77a436a3c71e753c7d659
https://doi.org/10.1021/acsmedchemlett.2c00441
https://doi.org/10.1021/acsmedchemlett.2c00441
Autor:
Lee Pellegrino, Monika Kandebo, Nicole K. Polinski, Mark Herberth, Leo B. Dungan, Robert Switzer, Gregory D. Ellsworth, Sean W. Clark, Alexander Gorodinsky, Robert E. Drolet, Peter D. Buckett, Mali Cosden, Michael Sasner, Ralph Gareus, Syed Omar Ahmad, Weisong Shan, Terina N. Martinez, Kuldip D. Dave, Warren D. Hirst, Yi Chen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252325 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252325 (2021)
Multiple mutations have been described in the human GBA1 gene, which encodes the lysosomal enzyme beta-glucocerebrosidase (GCase) that degrades glucosylceramide and is pivotal in glycosphingolipid substrate metabolism. Depletion of GCase, typically b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5768efebed44f52b94d2247e7ec2bf9
http://europepmc.org/articles/PMC8189458
http://europepmc.org/articles/PMC8189458
Autor:
Cornelis Blauwendraat, Sarah Jinn, Dawn Toolan, Andrew B. Singleton, Jacob Marcus, Robert E. Drolet, Sean M. Smith, David J. Stone, Cheryl A. Gretzula, Mike A. Nalls
Publikováno v:
Human Molecular Genetics
Multiple genome-wide association studies (GWAS) in Parkinson disease (PD) have identified a signal at chromosome 4p16.3; however, the causal variant has not been established for this locus. Deep investigation of the region resulted in one identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51249e3008ee1f9af30cb005c09f5cf
https://doi.org/10.1093/hmg/ddz136
https://doi.org/10.1093/hmg/ddz136
Autor:
Marla L. Watt, Sarah Jinn, Nathan G. Hatcher, Lei Ma, Mali Cosden, Monika Kandebo, Christine Burlein, Christina Minnick, Mark E. Fraley, Cheryl A. Gretzula, Wei Lemaire, Rose B. Flick, Sean M. Smith, James Mulhearn, Gregory C. Adam, Jacob Marcus, Robert E. Drolet, Dawn Toolan, Lihang Yao
Publikováno v:
Neurobiology of Disease, Vol 159, Iss, Pp 105507-(2021)
Mutations in the lysosomal enzyme glucocerebrosidase (GCase, GBA1 gene) are the most common genetic risk factor for developing Parkinson's disease (PD). GCase metabolizes the glycosphingolipids glucosylceramide (GlcCer) and glucosylsphingosine (GlcSp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cd5da06600d31f6c7bb67bb7f45f07
https://doi.org/10.1016/j.nbd.2021.105507
https://doi.org/10.1016/j.nbd.2021.105507
Autor:
Andus Hon-Kit Wong, Robert E. Drolet, Galya Vassileva, Cheryl A. Gretzula, Paige Cramer, Jyoti Disa, Marija Tadin-Strapps, David J. Stone, Bhavya Voleti, Sarah Jinn, Dawn Toolan
Publikováno v:
Proceedings of the National Academy of Sciences. 114:2389-2394
Parkinson disease (PD) is a neurodegenerative disorder pathologically characterized by nigrostriatal dopamine neuron loss and the postmortem presence of Lewy bodies, depositions of insoluble α-synuclein, and other proteins that likely contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac18fc109c991ebfd1af11dfbf9d4505
https://doi.org/10.1073/pnas.1616332114
https://doi.org/10.1073/pnas.1616332114
Autor:
Sophie Parmentier-Batteur, John J. Renger, Joel B. Schachter, Nathan G. Hatcher, Marija Usenovic, Robert E. Drolet, Renee C. Gaspar, Shahriar Niroomand, Lihang Yao
Publikováno v:
The Journal of Neuroscience. 35:14234-14250
Neuronal inclusions of hyperphosphorylated and aggregated tau protein are a pathological hallmark of several neurodegenerative tauopathies, including Alzheimer's disease (AD). The hypothesis of tau transmission in AD has emerged from histopathologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f9f2d5c1c89c380ff84a4551838bf1
https://doi.org/10.1523/jneurosci.1523-15.2015
https://doi.org/10.1523/jneurosci.1523-15.2015
Autor:
Joel M. Harris, Xiaoping Zhou, John A. Morrow, Sue-Ing Lin, Marco A. S. Baptista, John M. Sanders, Xiaoping Zhang, Hong Mei, Mark W. Embrey, Sylvie M. Sur, Duane E. DeMong, Ravi P. Nargund, Alan Hruza, Heather E. Tiscia, Matthew J. Fell, Zhizhang Yin, Gautam Agnihotri, Honglu Zhang, Thomas J. Greshock, Jack D. Scott, Yinghui Lin, Zhi-Cai Shi, John A. Mccauley, Sarah W. Li, Ronald K. Chang, Mark T. Bilodeau, Michael W. Miller, Reshma Kuvelkar, Andrew Stamford, Marc Poirier, Hong Liu, Megan K. Macala, Kallol Basu, Li Xiao, Lynn A. Hyde, Jonathan T. Kern, Xing Dai, Christian Mirescu, Paul L. Walsh, Matthew E. Kennedy, John J. Renger, Zhiyong Hu, John Columbus, Robert E. Drolet, Eric M. Parker
Publikováno v:
Journal of medicinal chemistry. 60(7)
Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein which contains a kinase domain and GTPase domain among other regions. Individuals possessing gain of function mutations in the kinase domain such as the most prevalent G2019S mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2ca3dd5156b7d725b7ec9d610b7b59
https://pubmed.ncbi.nlm.nih.gov/28245354
https://pubmed.ncbi.nlm.nih.gov/28245354