Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Robert E. Chapin"'
Publikováno v:
Birth Defects Research. 110:17-26
Background Testing of pharmaceutical products for reproductive toxicity in male laboratory animals is required for registration. Methods We evaluated whether the results of studies showing male reproductive toxicity in experimental animals was predic
Autor:
Bradley E. Enerson, Todd Wisialowski, Steven W. Kumpf, Dean Wilkie, Robert E. Chapin, Michael P. Lawton, Petra H. Koza-Taylor, Christopher Houle, Mark Gosink, Scott Davenport
Publikováno v:
Toxicological Sciences. 159:42-49
Drug-induced vascular injury (DIVI) in preclinical studies can delay, if not terminate, a drug development program. Clinical detection of DIVI can be very difficult as there are no definitive biomarkers known to reliably detect this disorder in all i
Autor:
Steven W. Kumpf, Jan-Bernd Stukenborg, Aleasha Coburn, Robert E. Chapin, Kjell Johnson, William S. Nowland, Nichole Danis, Timothy R. Winton
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 107:225-242
The last two decades have seen an increasing search for in vitro models that can replace the use of animals for safety testing. We adapted the methods from a recent nonquantitative report of spermatogenesis occurring in ex vivo mouse testis explants
Autor:
W. Mark Vogel, Steven W. Kumpf, Robert E. Chapin, Douglas J. Ball, Zaher A. Radi, Petra H. Koza-Taylor, David M. Potter
Publikováno v:
Toxicological Sciences. 155:148-156
Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis. Tofacitinib preferentially inhibits receptor signaling through JAK3 and JAK1, relative to JAK2. In the 2-year rat carcinogenicity study, there were tofacit
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 107:185-194
As alternative models and scientific advancements improve the ability to predict developmental toxicity, the challenge is how to best use this information to support safe use of pharmaceuticals in humans. While in vivo experimental data are often exp
Publikováno v:
Molecular Human Reproduction
Study question Do the organ culture conditions, previously defined for in vitro murine male germ cell differentiation, also result in differentiation of rat spermatogonia into post-meiotic germ cells exhibiting specific markers for haploid germ cells
Autor:
Robert E. Chapin, Dianne M. Creasy
Much of the work of the pathologist in understanding male reproductive toxicity comes from trying to understand the initial site of toxicant action – that is, distinguishing the initial effects from the follow-on events. These changes can happen be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dac35ef4262cea4a379a1aa817bfcaa
https://doi.org/10.1016/b978-0-12-809841-7.00017-4
https://doi.org/10.1016/b978-0-12-809841-7.00017-4
Autor:
William S. Nowland, Timothy M. Coskran, Elsa G. Barbacci-Tobin, Timothy R. Winton, Steven W. Kumpf, Sarah N. Campion, Robert E. Chapin, Scott Davenport, Christopher Houle, Randal D. Streck, David Karanian
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 101:325-332
Treatment-induced epididymal inflammation and granuloma formation is only an occasional problem in preclinical drug development, but it can effectively terminate the development of that candidate molecule. Screening for backup molecules without that
Comparative assessment of the timing of sexual maturation in male Wistar Han and Sprague-Dawley rats
Autor:
Sarah N. Campion, William S. Nowland, Timothy R. Winton, Gregg D. Cappon, Rebecca Koitz, Mark E. Hurtt, Francisco R. Carvallo, Raul T Jamon, David Beauchamp, Robert E. Chapin
Publikováno v:
Reproductive Toxicology. 38:16-24
Given the increasing use of Wistar Han (WH) rats in regulatory toxicology studies, these studies were performed to characterize the onset of sexual maturation in maturing WH rats as compared to Sprague-Dawley (SD) rats. Beginning on postnatal day (PN
Autor:
Brian P. Enright, Zoltan Erdos, James H. Kim, Gerhard F. Weinbauer, David Potter, Michelle Coulson, Michael S. Thibodeau, Jeffrey S. Moffit, William J. Breslin, Susan B. Laffan, Manisha Sonee, Richard Goldstein, William J. Reagan, Louise Parks Saldutti, Robert E. Chapin
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 98:110-118
The Developmental and Reproductive Toxicity Technical Committee of the Health and Environmental Sciences Institute hosted a working consortium of companies to evaluate a new commercially available analytic assay for Inhibin B in rat serum or plasma.