Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Robert E. Ashley"'
Autor:
Jian Guan, Stephanie M. Bywaters, Sarah A. Brendle, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Neil D. Christensen, Susan Hafenstein
Publikováno v:
Viruses, Vol 9, Iss 12, p 374 (2017)
Cancers attributable to human papillomavirus (HPV) place a huge burden on the health of both men and women. The current commercial vaccines are genotype specific and provide little therapeutic benefit to patients with existing HPV infections. Identif
Externí odkaz:
https://doaj.org/article/d1059fa76a8f4f7cb01af66e9e890a11
Autor:
Kristin L. Shingler, Jennifer L. Yoder, Michael S. Carnegie, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Susan Hafenstein
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9 (2013)
Externí odkaz:
https://doaj.org/article/f2f3a4b6de904059b6cd3941bc5b330c
Autor:
James F. Conway, Carol M. Bator, Daniel J. Goetschius, Susan Hafenstein, Robert E. Ashley, Alexander M. Makhov, Kai Huang, Lindsey J. Organtini, Samantha R. Hartmann, Colin R. Parrish, Heather M. Callaway
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Our study makes significant progress understanding asymmetry in icosahedral viruses that would be otherwise masked by forcing homogeneity through icosahedral averaging. Using an asymmetric approach revealed the atomic-resolution structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba536fc1069fb3cb0d1ab0a560d54900
https://doi.org/10.1073/pnas.2025452118
https://doi.org/10.1073/pnas.2025452118
Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site
Autor:
Susan Hafenstein, Robert E. Ashley, James F. Conway, Jian Guan, Neil D. Christensen, Stephanie M. Bywaters, Sarah A. Brendle, Alexander M. Makhov
Publikováno v:
Structure. 25:253-263
Human papillomavirus (HPV) is a significant health burden and leading cause of virus-induced cancers. The current commercial vaccines are genotype specific and provide little therapeutic benefit to patients with existing HPV infections. Host entry me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c1e24103a31ee208a97c4dd9b3385e
https://doi.org/10.1016/j.str.2016.12.001
https://doi.org/10.1016/j.str.2016.12.001
Autor:
Stephanie M. Bywaters, Jian Guan, Sarah A. Brendle, Hyunwook Lee, Susan Hafenstein, Robert E. Ashley, Neil D. Christensen
Publikováno v:
Journal of Virology. 89:12108-12117
The human papillomavirus (HPV) major structural protein L1 composes capsomers that are linked together through interactions mediated by the L1 C terminus to constitute a T=7 icosahedral capsid. H16.U4 is a type-specific monoclonal antibody recognizin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b99275015bb607e3b3cf3ecbbd936bf
https://doi.org/10.1128/jvi.02020-15
https://doi.org/10.1128/jvi.02020-15
Autor:
Robert E. Ashley, Neil D. Christensen, Susan Hafenstein, Sarah A. Brendle, Alexander M. Makhov, Jian Guan, Stephanie M. Bywaters, James F. Conway
Publikováno v:
Viruses, Vol 9, Iss 12, p 374 (2017)
Viruses
Viruses; Volume 9; Issue 12; Pages: 374
Viruses
Viruses; Volume 9; Issue 12; Pages: 374
Cancers attributable to human papillomavirus (HPV) place a huge burden on the health of both men and women. The current commercial vaccines are genotype specific and provide little therapeutic benefit to patients with existing HPV infections. Identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24943cec76995d0198cdd9888bae3dc4
https://www.mdpi.com/1999-4915/9/12/374
https://www.mdpi.com/1999-4915/9/12/374
Autor:
Alexander M. Makhov, Neil D. Christensen, James F. Conway, Joshua D. Yoder, Stephanie M. Bywaters, Sarah A. Brendle, Hyunwook Lee, Robert E. Ashley, Jian Guan, Susan Hafenstein
Publikováno v:
Journal of Virology. 89:1428-1438
Human papillomavirus 16 (HPV16) is a worldwide health threat and an etiologic agent of cervical cancer. To understand the antigenic properties of HPV16, we pursued a structural study to elucidate HPV capsids and antibody interactions. The cryo-electr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce434628304d4d0549ce58e05821e199
https://doi.org/10.1128/jvi.02898-14
https://doi.org/10.1128/jvi.02898-14
Honey Bee Deformed Wing Virus Structures Reveal that Conformational Changes Accompany Genome Release
Autor:
Kulsoom Durrani, Alexander M. Makhov, Marie C. Pizzorno, Elizabeth A. Capaldi, Lindsey J. Organtini, Kristin L. Shingler, James F. Conway, Susan Hafenstein, Robert E. Ashley, Kelly A. Dryden
Publikováno v:
Journal of Virology. 91
The picornavirus-like deformed wing virus (DWV) has been directly linked to colony collapse; however, little is known about the mechanisms of host attachment or entry for DWV or its molecular and structural details. Here we report the three-dimension
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e65eadce7431925bf7c9274549de633
https://doi.org/10.1128/jvi.01795-16
https://doi.org/10.1128/jvi.01795-16
Autor:
Yoshio Tano, Javier O. Cifuente, Hiroyuki Shimizu, James F. Conway, Hyunwook Lee, Alexander M. Makhov, Robert E. Ashley, Yorihiro Nishimura, Susan Hafenstein
Publikováno v:
Journal of Virology. 87:11363-11370
Enterovirus 71 (EV71) is a picornavirus that causes outbreaks of hand, foot, and mouth disease (HFMD), primarily in the Asia-Pacific area. Unlike coxsackievirus A16, which also causes HFMD, EV71 induces severe neuropathology leading to high fatalitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf0c7c25bf7718b9fcfc7f7547a9195
https://doi.org/10.1128/jvi.01926-13
https://doi.org/10.1128/jvi.01926-13
Autor:
Charlotta Polacek, Bartosz Muszynski, Maria Gullberg, Lindsey J. Organtini, Graham J. Belsham, Robert E. Ashley, Susan Hafenstein
Publikováno v:
Journal of General Virology. 94:1769-1779
The foot-and-mouth disease virus (FMDV) structural protein precursor, P1-2A, is cleaved by the virus-encoded 3C protease (3Cpro) into the capsid proteins VP0, VP1 and VP3 (and 2A). In some systems, it is difficult to produce large amounts of these pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5274539e8952ac39576116cf5b207585
https://doi.org/10.1099/vir.0.054122-0
https://doi.org/10.1099/vir.0.054122-0