Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Robert E Thompson"'
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61459 (2013)
Fluoroquinolones are very important drugs in the clinical antibacterial arsenal; their success is principally due to their mode of action: the stabilisation of a gyrase-DNA intermediate (the cleavage complex), which triggers a chain of events leading
Externí odkaz:
https://doaj.org/article/99fdc5b66dc44db0b0e2283114866e7f
Autor:
Qingfei Zheng, Ryan M. Bastle, Shuai Zhao, Lingchun Kong, Lauren Vostal, Aarthi Ramakrishnan, Li Shen, Sasha L. Fulton, Haifeng Wang, Baichao Zhang, Akhil Upad, Robert E. Thompson, Henrik Molina, Stephanie Stransky, Simone Sidoli, Tom W. Muir, Haitao Li, Yael David, Ian Maze
Histone H3 monoaminylations at glutamine(Q) 5 represent an important family of epigenetic markers in neurons that play critical roles in the mediation of permissive gene expression (1, 2). We previously demonstrated that H3Q5 serotonylation(ser) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39f4bcd087bc9641bf57dddcc13738e2
https://doi.org/10.1101/2022.12.06.519310
https://doi.org/10.1101/2022.12.06.519310
Autor:
Bradley J. Lukasak, Robert E. Thompson, Michelle M. Mitchener, Vanessa J. Feng, John D. Bagert, Tom W. Muir
Publikováno v:
ACS central science. 8(2)
Nucleosomes frequently exist as asymmetric species in native chromatin contexts. Current methods for the traceless generation of these heterotypic chromatin substrates are inefficient and/or difficult to implement. Here, we report an application of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7d9702f36df208235ca4be88dcc7d5
https://pubmed.ncbi.nlm.nih.gov/35233450
https://pubmed.ncbi.nlm.nih.gov/35233450
Autor:
Tom W. Muir, Robert E. Thompson
Publikováno v:
Chem Rev
Protein semisynthesis – defined herein as the assembly of a protein from a combination of synthetic and recombinant fragments - is a burgeoning field of chemical biology that has impacted many areas in the life sciences. In this review, we provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37deb91e16d218aecd213bf139c70d3c
https://doi.org/10.1021/acs.chemrev.9b00450
https://doi.org/10.1021/acs.chemrev.9b00450
Autor:
Ian Maze, Kelly J. Heard, Natalia Alenina, Henrik Molina, Bradley J. Lukasak, Ryan M. Bastle, Fred H. Gage, Michael Bader, Tom W. Muir, Krishna C. Vadodaria, Baichao Zhang, Robert E. Thompson, Natarajan V. Bhanu, Robert G. Roeder, Shuai Zhao, Tomoyoshi Nakadai, Yang Lyu, Aarthi Ramakrishnan, Olivier Berton, Lorna A. Farrelly, Li Shen, Henry Zebroski, Haitao Li, Benjamin A. Garcia, Ashley E. Lepack, Galina Erikson, Yong-Hwee E. Loh
Publikováno v:
Nature. 567:535-539
Chemical modifications of histones can mediate diverse DNA-templated processes, including gene transcription1–3. Here we provide evidence for a class of histone post-translational modification, serotonylation of glutamine, which occurs at position
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6c9a79ccc89fe0271131086b5e6c2e8
https://doi.org/10.1038/s41586-019-1024-7
https://doi.org/10.1038/s41586-019-1024-7
Autor:
Baichao Zhang, Ning Xu, Yi Xue, Robert E. Thompson, Ian Maze, Robert G. Roeder, Tom W. Muir, Shuai Zhao, Xiaohui Liu, Haitao Li, Lorna A. Farrelly, Kelly N. Chuh, Barbara E. Dul
Publikováno v:
Proc Natl Acad Sci U S A
Serotonylation of glutamine 5 on histone H3 (H3Q5ser) was recently identified as a permissive posttranslational modification that coexists with adjacent lysine 4 trimethylation (H3K4me3). While the resulting dual modification, H3K4me3Q5ser, is enrich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4280fabd4d7fe1c8ed8950b6c27f432
https://europepmc.org/articles/PMC8017887/
https://europepmc.org/articles/PMC8017887/
Publikováno v:
Emerging Infectious Diseases, Vol 9, Iss 4, Pp 480-482 (2003)
Scrub typhus, caused by Orientia tsutsugamushi, occurs throughout Southeast Asia. We descript ten cases that occurred in the Torres Strait islands of northern Australia during 2000 and 2001. Preceding heavy rain may have contributed to the outbreak.
Externí odkaz:
https://doaj.org/article/fc776666db3a4bebb5226e97cd24b702
Autor:
Imala Alwis, Jorge Ripoll-Rozada, Pedro Pereira, Choy-Theng Loh, Mike Wu, Robert E. Thompson, Gottfried Otting, Shaun P. Jackson, Emma E. Watson, Xuyu Liu, Richard J. Payne, Benjamin L. Parker, Alessandro Gori
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Central Science, Vol 4, Iss 4, Pp 468-476 (2018)
ACS Central Science
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Central Science, Vol 4, Iss 4, Pp 468-476 (2018)
ACS Central Science
The anophelins are small protein thrombin inhibitors that are produced in the salivary glands of the Anopheles mosquito to fulfill a vital role in blood feeding. A bioinformatic analysis of anophelin sequences revealed the presence of conserved tyros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3458cdb95b6867cf76f215a2669021
https://doi.org/10.1021/acscentsci.7b00612
https://doi.org/10.1021/acscentsci.7b00612
Publikováno v:
Protein Science. 27:614-619
Naturally split inteins mediate a traceless protein ligation process known as protein trans-splicing (PTS). Although frequently used in protein engineering applications, the efficiency of PTS can be reduced by the tendency of some split intein fusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a538b06e540d1a3c359e606488f7d15e
https://doi.org/10.1002/pro.3357
https://doi.org/10.1002/pro.3357
Autor:
Richard J. Payne, Benjamin L. Parker, Pedro Pereira, Xuyu Liu, Noelia Alonso-García, Robert E. Thompson, Jorge Ripoll-Rozada
Publikováno v:
Nature Chemistry. 9:909-917
Madanin-1 and chimadanin are two small cysteine-free thrombin inhibitors that facilitate blood feeding in the tick Haemaphysalis longicornis. Here, we report a post-translational modification—tyrosine sulfation—of these two proteins that is criti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a2c29633780c0b56c7a975d5b9efc3
https://doi.org/10.1038/nchem.2744
https://doi.org/10.1038/nchem.2744