Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Robert E London"'
Publikováno v:
eLife, Vol 4 (2015)
HIV-1 reverse transcriptase utilizes a metamorphic polymerase domain that is able to adopt two alternate structures that fulfill catalytic and structural roles, thereby minimizing its coding requirements. This ambiguity introduces folding challenges
Externí odkaz:
https://doaj.org/article/f1f5a5c9a0d04fffbc12ec4e116df008
Autor:
Thomas W. Kirby, Scott A. Gabel, Eugene F. DeRose, Lalith Perera, Juno M. Krahn, Lars C. Pedersen, Robert E. London
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1603 (2023)
Formation of active HIV-1 reverse transcriptase (RT) proceeds via a structural maturation process that involves subdomain rearrangements and formation of an asymmetric p66/p66′ homodimer. These studies were undertaken to evaluate whether the inform
Externí odkaz:
https://doaj.org/article/376b12fa42bb4eceacdfd0459bcc8b10
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Human Nbs1, a component of the MRN complex involved in DNA double strand break repair, contains a concatenated N-terminal FHA-BRCT1/2 sequence that supports interaction with multiple phosphopeptide binding partners. MDC1 binding localizes Nb
Externí odkaz:
https://doaj.org/article/84fb1171b31f475c9785c36d1516f766
Autor:
Bradley P, Klemm, Deepa, Singh, Cassandra E, Smith, Allen L, Hsu, Lucas B, Dillard, Juno M, Krahn, Robert E, London, Geoffrey A, Mueller, Mario J, Borgnia, Roel M, Schaaper
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(37)
Levels of the cellular dNTPs, the direct precursors for DNA synthesis, are important for DNA replication fidelity, cell cycle control, and resistance against viruses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f8f7ec4e6a8fb59038bd37189953473
https://pubmed.ncbi.nlm.nih.gov/36067314
https://pubmed.ncbi.nlm.nih.gov/36067314
Autor:
Bradley P. Klemm, Deepa Singh, Cassandra E. Smith, Allen L. Hsu, Lucas B. Dillard, Juno M. Krahn, Robert E. London, Geoffrey A. Mueller, Mario J. Borgnia, Roel M. Schaaper
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Levels of the cellular dNTPs, the direct precursors for DNA synthesis, are important for DNA replication fidelity, cell cycle control, and resistance against viruses. Escherichia coli encodes a dGTPase (2′-deoxyguanosine-5′-triphosphate [dGTP] tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a4e42da2ab3f1e7ea98051372b7c643
https://doi.org/10.1073/pnas.2123092119
https://doi.org/10.1073/pnas.2123092119
Autor:
Bradley J. Collins, Kristin Aillon, Eugene F. DeRose, Cynthia V. Rider, Robert E. London, Suramya Waidyanatha, James M. Harnly, Geoffrey A. Mueller, Season P. Kerns
Publikováno v:
Analytical and Bioanalytical Chemistry
Ginkgo biloba extract (GbE) is a dietary supplement derived from an ethanolic extract of Ginkgo biloba leaves. Unfinished bulk GbE is used to make finished products that are sold as dietary supplements. The variable, complex composition of GbE makes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2533e5797929833c2ad692df316d62c9
https://doi.org/10.1007/s00216-020-02839-7
https://doi.org/10.1007/s00216-020-02839-7
Autor:
Lars C. Pedersen, Robert E. London, Elizabeth E. Howell, Scott A. Gabel, Juno M. Krahn, Michael R. Duff, Eugene F. DeRose
Publikováno v:
J Med Chem
Although nonsteroidal anti-inflammatory drugs (NSAIDs) target primarily cyclooxygenase enzymes, a subset of NSAIDs containing carboxylate groups also has been reported to competitively inhibit dihydrofolate reductase (DHFR). In this study, we have ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87856884455707440c1eaf986117e32f
https://doi.org/10.1021/acs.jmedchem.0c00546
https://doi.org/10.1021/acs.jmedchem.0c00546
Autor:
Robert E. London
Publikováno v:
Structure. 27:420-426
There has been a steadily increasing appreciation of the fact that the relationship between protein sequence and structure is often sufficiently ambiguous to allow a single sequence to adopt alternative, stable folds. Living organisms have been able
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a22ae56b0488aa15eff2602c3010876
https://doi.org/10.1016/j.str.2018.11.011
https://doi.org/10.1016/j.str.2018.11.011
Autor:
Eugene F. DeRose, Bradley J. Collins, Kristin Aillon, Suramya Waidyanatha, Season P. Kerns, Cynthia V. Rider, James M. Harnly, Robert E. London, Geoffrey A. Mueller
Publikováno v:
Anal Bioanal Chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6c5e30d9ca0e2648c28fff8fbfeb2d
https://europepmc.org/articles/PMC8587371/
https://europepmc.org/articles/PMC8587371/
Autor:
Robert E. London
Publikováno v:
Viruses, Vol 8, Iss 10, p 260 (2016)
Human immunodeficiency virus 1 (HIV-1) reverse transcriptase (RT)—a critical enzyme of the viral life cycle—undergoes a complex maturation process, required so that a pair of p66 precursor proteins can develop conformationally along different pat
Externí odkaz:
https://doaj.org/article/ebf6eb051d35407c91cdcde435398dbd