Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Robert E Hill"'
Autor:
David Mellis, Katherine A Staines, Silvia Peluso, Ioanna Ch Georgiou, Natalie Dora, Malgorzata Kubiak, Rob Van't Hof, Michela Grillo, Colin Farquharson, Elaine Kinsella, Anna Thornburn, Stuart H Ralston, Donald M Salter, Natalia A Riobo-Del Galdo, Robert E Hill, Mark Ditzel
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009275 (2021)
Mammalian Hedgehog (HH) signalling pathway plays an essential role in tissue homeostasis and its deregulation is linked to rheumatological disorders. UBR5 is the mammalian homologue of the E3 ubiquitin-protein ligase Hyd, a negative regulator of the
Externí odkaz:
https://doaj.org/article/7d80a4cd974e4d41902b984699e2a974
Autor:
Silvia Peluso, Adam Douglas, Alison Hill, Carlo De Angelis, Benjamin L Moore, Graeme Grimes, Giulia Petrovich, Abdelkader Essafi, Robert E Hill
Publikováno v:
eLife, Vol 6 (2017)
Sonic hedgehog (Shh) expression in the limb bud organizing centre called the zone of polarizing activity is regulated by the ZRS enhancer. Here, we examine in mouse and in a mouse limb-derived cell line the dynamic events that activate and restrict t
Externí odkaz:
https://doaj.org/article/57a9b1e518c742868362ba4b6c256a7b
Autor:
Duomeng Yang, Tingting Geng, Andrew G. Harrison, Jason G. Cahoon, Jian Xing, Baihai Jiao, Mark Wang, Chao Cheng, Robert E. Hill, Huadong Wang, Anthony T. Vella, Gong Cheng, Yanlin Wang, Penghua Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The Retinoic acid-Inducible Gene I (RIG-I) like receptors (RLRs) are the major viral RNA sensors essential for the initiation of antiviral immune responses. RLRs are subjected to stringent transcriptional and posttranslational regulations, o
Externí odkaz:
https://doaj.org/article/23aeb1067fec4617961dd3dbc171d41f
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109193 (2014)
Eye phenotypes were investigated in Le-Cre(Tg/-); Pax6(fl/+) mice, which were expected to show tissue-specific reduction of Pax6 in surface ectoderm derivatives. To provide a better comparison with our previous studies of Pax6(+/-) eye phenotypes, he
Externí odkaz:
https://doaj.org/article/631a27764f4d4615b0db9a0cf08fd051
Autor:
Panagiotis Douvaras, Richard L Mort, Dominic Edwards, Kanna Ramaesh, Baljean Dhillon, Steven D Morley, Robert E Hill, John D West
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71117 (2013)
We aimed to test previous predictions that limbal epithelial stem cells (LESCs) are quantitatively deficient or qualitatively defective in Pax6(+/-) mice and decline with age in wild-type (WT) mice. Consistent with previous studies, corneal epithelia
Externí odkaz:
https://doaj.org/article/c3e3255cbdd045b4923635016e205e80
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21753 (2011)
Despite the extensive use of the mouse as a model for studies of pancreas development and disease, the development of the gastric pancreatic lobe has been largely overlooked. In this study we use optical projection tomography to provide a detailed th
Externí odkaz:
https://doaj.org/article/d1ab4d2dfeea4cb18890e1fb8f7be597
Autor:
Richard L Mort, Adam J Bentley, Francis L Martin, J Martin Collinson, Panagiotis Douvaras, Robert E Hill, Steven D Morley, Nigel J Fullwood, John D West
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28895 (2011)
Altered dosage of the transcription factor PAX6 causes multiple human eye pathophysiologies. PAX6⁺/⁻ heterozygotes suffer from aniridia and aniridia-related keratopathy (ARK), a corneal deterioration that probably involves a limbal epithelial ste
Externí odkaz:
https://doaj.org/article/76f729e253d1417eadba95424dc96e78
Autor:
Lauren Kane, Iain Williamson, Ilya M. Flyamer, Yatendra Kumar, Robert E. Hill, Laura A. Lettice, Wendy A. Bickmore
Publikováno v:
Kane, L, Williamson, I, Flyamer, I, Kumar, Y, Hill, R E, Lettice, L A & Bickmore, W A 2022, ' Cohesin is required for long-range enhancer action at the Shh locus ', Nature Structural & Molecular Biology, vol. 29, no. 9, pp. 891-897 . https://doi.org/10.1038/s41594-022-00821-8
Nat Struct Mol Biol
Nat Struct Mol Biol
The regulatory landscapes of developmental genes in mammals can be complex, with enhancers spread over many hundreds of kilobases. It has been suggested that three-dimensional genome organisation, particularly topologically associating domains formed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005cf46e25b276610ee986e6f1825e97
https://www.pure.ed.ac.uk/ws/files/288068812/Kane_NSMB_accepted.pdf
https://www.pure.ed.ac.uk/ws/files/288068812/Kane_NSMB_accepted.pdf
Autor:
Lauren Kane, Laura A. Lettice, Wendy A. Bickmore, Yatendra Kumar, Ilya M. Flyamer, Iain Williamson, Robert E. Hill
SummaryThe mammalian genome is organised into topologically associating domains (TADs) that are formed through the process of cohesin-driven loop extrusion1–3 and whose extent is constrained at TAD boundaries by orientation-dependent CTCF binding4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7759a86a6786073770fc1374e398f871
https://doi.org/10.1101/2021.06.24.449812
https://doi.org/10.1101/2021.06.24.449812
Autor:
Michela Grillo, Natalia A. Riobo-Del Galdo, Robert E. Hill, Malgorzata Kubiak, David Mellis, Elaine Kinsella, Donald Salter, Ioanna Ch. Georgiou, Katherine Staines, Silvia Peluso, Rob van't Hof, Anna Thornburn, Natalie Dora, Stuart H. Ralston, Colin Farquharson, Mark Ditzel
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009275 (2021)
PLOS GENETICS
Mellis, D, Staines, K, Peluso, S, Georgiou, I C, Dora, N, Kubiak, M, van't Hof, R, Grillo, M, Farquharson, C, Kinsella, E, Thornburn, A, Ralston, S H, Salter, D M, Riobo-Del Galdo, N A, Hill, R E & Ditzel, M 2021, ' Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis. ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1009275
PLoS Genetics
PLOS GENETICS
Mellis, D, Staines, K, Peluso, S, Georgiou, I C, Dora, N, Kubiak, M, van't Hof, R, Grillo, M, Farquharson, C, Kinsella, E, Thornburn, A, Ralston, S H, Salter, D M, Riobo-Del Galdo, N A, Hill, R E & Ditzel, M 2021, ' Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis. ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1009275
PLoS Genetics
Mammalian Hedgehog (HH) signalling pathway plays an essential role in tissue homeostasis and its deregulation is linked to rheumatological disorders. UBR5 is the mammalian homologue of the E3 ubiquitin-protein ligase Hyd, a negative regulator of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a52668b3bca56103d39e02d6dfc082
https://eprints.whiterose.ac.uk/173526/1/journal.pgen.1009275.pdf
https://eprints.whiterose.ac.uk/173526/1/journal.pgen.1009275.pdf