Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Robert E, Widdop"'
Autor:
Yifang Li, Alex Hunter, Miqdad M. Wakeel, Guizhi Sun, Ricky W. K. Lau, Brad R. S. Broughton, Ivan E. Oyarce Pino, Zihao Deng, Tingfang Zhang, Padma Murthi, Mark P. Del Borgo, Robert E. Widdop, Jose M. Polo, Sharon D. Ricardo, Chrishan S. Samuel
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Background Kidney fibrosis is a hallmark of chronic kidney disease (CKD) and compromises the viability of transplanted human bone marrow-derived mesenchymal stromal cells (BM-MSCs). Hence, BM-MSCs were genetically-engineered to express the a
Externí odkaz:
https://doaj.org/article/d6c0ff1090e149c8a2dd546898ac8e05
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The photothrombotic stroke model relies on the interaction between photosensitive-dye and light for clot formation. Interestingly, the relationship between the length of light exposure and stroke-outcome has never been examined. This model h
Externí odkaz:
https://doaj.org/article/1e4c1c51fead401398d34fd1805ae521
Autor:
U. Muscha Steckelings, Robert E. Widdop, Edward D. Sturrock, Lizelle Lubbe, Tahir Hussain, Elena Kaschina, Thomas Unger, Anders Hallberg, Robert M. Carey, Colin Sumners
Publikováno v:
Pharmacological Reviews. 74:1051-1135
Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from a binding site with unknown function to a firmly established major effector within the protective arm of the renin-angiotensin system (RAS) and a target for new d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed01bea095fdd625441059db2d80f05
https://doi.org/10.1124/pharmrev.120.000281
https://doi.org/10.1124/pharmrev.120.000281
Publikováno v:
British Journal of Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7af6b1709a6dba49e63b0ec28fd4a5e
https://doi.org/10.1111/bph.16019
https://doi.org/10.1111/bph.16019
Autor:
Tracey J. Flores, Vivian B. Nguyen, Robert E. Widdop, Megan R. Sutherland, Graeme R. Polglase, Helen E. Abud, Mary Jane Black
Publikováno v:
Frontiers in Pediatrics, Vol 6 (2018)
BackgroundFor infants born moderately/late preterm (32–37 weeks of gestation), immaturity of the intestine has the potential to impact both short- and long-term gastrointestinal function. The aim of this study conducted in sheep was to compare the
Externí odkaz:
https://doaj.org/article/ba799f6e2e7a43f3b120bd0609aea4c4
Autor:
Robert E Widdop, Katrina M Mirabito Colafella, Tracey Gaspari, Edmund Kwok, Anita A. Pinar, Giannie Barsha, Sarah L. Walton, Kate M. Denton, Chrishan S. Samuel, Lucinda M. Hilliard Krause
Publikováno v:
Kidney360
BACKGROUND: The antifibrotic effects of recombinant human relaxin (RLX) in the kidney are dependent on an interaction between its cognate receptor (RXFP1) and the angiotensin type 2 receptor (AT(2)R) in male models of disease. Whether RLX has therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c4877c40e9e472f7ebc41c3e9d5b03
https://doi.org/10.34067/kid.0002722021
https://doi.org/10.34067/kid.0002722021
Publikováno v:
British journal of pharmacology.
Class A rhodopsin-like G protein-coupled receptors (GPCRs) are by far the largest class of GPCRs, and are integral membrane proteins that are used by various cells to convert extracellular signals into intracellular responses. Initially, class A GPCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b084b4e0f127e6f8e59df0f56418ac0
https://pubmed.ncbi.nlm.nih.gov/36560925
https://pubmed.ncbi.nlm.nih.gov/36560925
Autor:
Yan Wang, Jonathan Yodgee, Mark Del Borgo, Iresha Spizzo, Levi Nguyen, Marie-Isabel Aguilar, Kate M. Denton, Chrishan S. Samuel, Robert E. Widdop
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 14039
A high salt (HS) diet is associated with an increased risk for cardiovascular diseases (CVDs) and fibrosis is a key contributor to the organ dysfunction involved in CVDs. The activation of the renin angiotensin type 2 receptor (AT2R) has been conside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59efdb12fd008e3e83fbecabb09dcaf8
https://pubmed.ncbi.nlm.nih.gov/36430518
https://pubmed.ncbi.nlm.nih.gov/36430518
Autor:
Yan Wang, Mark Del Borgo, Huey W. Lee, Dhaniel Baraldi, Baydaa Hirmiz, Tracey A. Gaspari, Kate M. Denton, Marie-Isabel Aguilar, Chrishan S. Samuel, Robert E. Widdop
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
There are a number of therapeutic targets to treat organ fibrosis that are under investigation in preclinical models. There is increasing evidence that stimulation of the angiotensin II type 2 receptor (AT2R) is a novel anti-fibrotic strategy and we
Externí odkaz:
https://doaj.org/article/b9ce0781ba6748188b248bbdc42a2555
Publikováno v:
F1000Research, Vol 6 (2017)
Hypertension, or high blood pressure, is a prevalent yet modifiable risk factor for cardiovascular disease. While there are many effective treatments available to combat hypertension, patients often require at least two to three medications to contro
Externí odkaz:
https://doaj.org/article/135254f5a7b04737b25301c0771c2502