Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Robert E, Sinden"'
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/8f41938691c64fa4a950f5e6669d9fef
Autor:
Michael J. Delves, Celia Miguel-Blanco, Holly Matthews, Irene Molina, Andrea Ruecker, Sabrina Yahiya, Ursula Straschil, Matthew Abraham, María Luisa León, Oliver J. Fischer, Ainoa Rueda-Zubiaurre, Jochen R. Brandt, Álvaro Cortés, Anna Barnard, Matthew J. Fuchter, Félix Calderón, Elizabeth A. Winzeler, Robert E. Sinden, Esperanza Herreros, Francisco J. Gamo, Jake Baum
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Sexual forms of malaria parasites are responsible for transmission to the mosquito. Anti-malarial drug resistance remains a serious problem and requires advent of new drug therapies. Here, the authors present a high-throughput screen of potential ant
Externí odkaz:
https://doaj.org/article/920f37303ca446e0a2ceaa2cbd0d76bf
Autor:
Chandra Ramakrishnan, Cécile Fort, Sara Rute Marques, David J. P. Ferguson, Marion Gransagne, Jake Baum, Soraya Chaouch, Elisabeth Mouray, Linda Kohl, Richard J. Wheeler, Robert E. Sinden
Publikováno v:
Journal of Cell Science.
Flagella are important for eukaryote cell motility, including in sperm, and are vital for life cycle progression of many unicellular eukaryotic pathogens. The “9+2” axoneme in most motile flagella comprises nine outer doublet and two central-pair
Autor:
Celia Miguel-Blanco, Irene Molina, Ana I. Bardera, Beatriz Díaz, Laura de las Heras, Sonia Lozano, Carolina González, Janneth Rodrigues, Michael J. Delves, Andrea Ruecker, Gonzalo Colmenarejo, Sara Viera, María S. Martínez-Martínez, Esther Fernández, Jake Baum, Robert E. Sinden, Esperanza Herreros
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
There is a need forPlasmodium transmission blocking drugs for malaria elimination. Here, Miguel-Blanco et al. screen >10,000 compounds against stage V female gametocytes, identify active compounds belonging to 57 chemotypes and confirm transmission b
Externí odkaz:
https://doaj.org/article/ca4505d3d02c492988049e0313f6978a
Autor:
Paul M. O’Neill, Richard K. Amewu, Susan A. Charman, Sunil Sabbani, Nina F. Gnädig, Judith Straimer, David A. Fidock, Emma R. Shore, Natalie L. Roberts, Michael H.-L. Wong, W. David Hong, Chandrakala Pidathala, Chris Riley, Ben Murphy, Ghaith Aljayyoussi, Francisco Javier Gamo, Laura Sanz, Janneth Rodrigues, Carolina Gonzalez Cortes, Esperanza Herreros, Iñigo Angulo-Barturén, María Belén Jiménez-Díaz, Santiago Ferrer Bazaga, María Santos Martínez-Martínez, Brice Campo, Raman Sharma, Eileen Ryan, David M. Shackleford, Simon Campbell, Dennis A. Smith, Grennady Wirjanata, Rintis Noviyanti, Ric N. Price, Jutta Marfurt, Michael J. Palmer, Ian M. Copple, Amy E. Mercer, Andrea Ruecker, Michael J. Delves, Robert E. Sinden, Peter Siegl, Jill Davies, Rosemary Rochford, Clemens H. M. Kocken, Anne-Marie Zeeman, Gemma L. Nixon, Giancarlo A. Biagini, Stephen A. Ward
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Artemisinin-resistantPlasmodium is an increasing problem. Here, using a medicinal chemistry programme, the authors identify a tetraoxane-based drug candidate that shows no cross-resistance with an artemisinin-resistant strain (PfK13-C580Y) and is eff
Externí odkaz:
https://doaj.org/article/d0b09995908d4fd1a466aa398f702f2f
Autor:
Felix Evers, Rona Roverts, Cas Boshoven, Mariska Kea-te Lindert, Julie M.J. Verhoef, Robert E. Sinden, Anat Akiva, Taco W.A. Kooij
Despite the enormous significance of malaria parasites for global health, some basic features of their ultrastructure remain obscure. In this study, we apply high-resolution volumetric electron microscopy to examine and compare the ultrastructure ofP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa5529fc224b9977a44c970b7fff22f7
https://doi.org/10.1101/2023.03.10.531920
https://doi.org/10.1101/2023.03.10.531920
Autor:
Robert E Sinden
Publikováno v:
PLoS Pathogens, Vol 13, Iss 7, p e1006336 (2017)
Externí odkaz:
https://doaj.org/article/87c6e5cc4c4e4079a644cb68c10985b4
Autor:
Thomas S Churcher, Robert E Sinden, Nick J Edwards, Ian D Poulton, Thomas W Rampling, Patrick M Brock, Jamie T Griffin, Leanna M Upton, Sara E Zakutansky, Katarzyna A Sala, Fiona Angrisano, Adrian V S Hill, Andrew M Blagborough
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006108 (2017)
Over a century since Ronald Ross discovered that malaria is caused by the bite of an infectious mosquito it is still unclear how the number of parasites injected influences disease transmission. Currently it is assumed that all mosquitoes with saliva
Externí odkaz:
https://doaj.org/article/06b851e695e24547811f54f463879571
Autor:
Elisabet Martí Coma-Cros, Arnau Biosca, Joana Marques, Laura Carol, Patricia Urbán, Diana Berenguer, Maria Cristina Riera, Michael Delves, Robert E. Sinden, Juan José Valle-Delgado, Lefteris Spanos, Inga Siden-Kiamos, Paula Pérez, Krijn Paaijmans, Matthias Rottmann, Amedea Manfredi, Paolo Ferruti, Elisabetta Ranucci, Xavier Fernàndez-Busquets
Publikováno v:
Pharmaceutics, Vol 10, Iss 4, p 225 (2018)
Current strategies for the mass administration of antimalarial drugs demand oral formulations to target the asexual Plasmodium stages in the peripheral bloodstream, whereas recommendations for future interventions stress the importance of also target
Externí odkaz:
https://doaj.org/article/b295ff5e39894a82946f782bfd2b62ec
Autor:
Maria L. Vainieri, Andrew M. Blagborough, Adam L. MacLean, Myriam L. R. Haltalli, Nicola Ruivo, Helen A. Fletcher, Michael P. H. Stumpf, Robert E. Sinden, Cristina Lo Celso
Publikováno v:
Open Biology, Vol 6, Iss 6 (2016)
Haematopoiesis is the complex developmental process that maintains the turnover of all blood cell lineages. It critically depends on the correct functioning of rare, quiescent haematopoietic stem cells (HSCs) and more numerous, HSC-derived, highly pr
Externí odkaz:
https://doaj.org/article/b09510d8c08145aabe392e5b20bd8b38