Zobrazeno 1 - 10
of 238
pro vyhledávání: '"Robert E, Donahue"'
Autor:
Naoya Uchida, Ulana Stasula, Selami Demirci, Paula Germino-Watnick, Malikiya Hinds, Anh Le, Rebecca Chu, Alexander Berg, Xiong Liu, Ling Su, Xiaolin Wu, Allen E. Krouse, N. Seth Linde, Aylin Bonifacino, So Gun Hong, Cynthia E. Dunbar, Leanne Lanieri, Anjali Bhat, Rahul Palchaudhuri, Bindu Bennet, Megan Hoban, Kirk Bertelsen, Lisa M. Olson, Robert E. Donahue, John F. Tisdale
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Hematopoietic stem cell (HSC) gene therapy has curative potential; however, its use is limited by the morbidity and mortality associated with current chemotherapy-based conditioning. Targeted conditioning using antibody-drug conjugates (ADC)
Externí odkaz:
https://doaj.org/article/da5777a8fdb54d1094c35c66359052e6
Autor:
Khaled Essawi, Waleed Hakami, Muhammad Behroz Naeem Khan, Reid Martin, Jing Zeng, Rebecca Chu, Naoya Uchida, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Robert E. Donahue, Gerd A. Blobel, Ulrike Gerdemann, Leslie S. Kean, Stacy A. Maitland, Scot A. Wolfe, Jean-Yves Metais, Stephen Gottschalk, Daniel E. Bauer, John F. Tisdale, Selami Demirci
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 483-493 (2023)
CRISPR-Cas9-based therapeutic genome editing approaches hold promise to cure a variety of human diseases. Recent findings demonstrate pre-existing immunity for the commonly used Cas orthologs from Streptococcus pyogenes (SpCas9) and Staphylococcus au
Externí odkaz:
https://doaj.org/article/186bb2a612c54f99a14f07e9473590ec
Autor:
Scott A. Peslak, Selami Demirci, Vemika Chandra, Byoung Ryu, Saurabh K. Bhardwaj, Jing Jiang, Jeremy W. Rupon, Robert E. Throm, Naoya Uchida, Alexis Leonard, Khaled Essawi, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Robert E. Donahue, Francesca Ferrara, Matthew Wielgosz, Osheiza Abdulmalik, Nicole Hamagami, Paula Germino-Watnick, Anh Le, Rebecca Chu, Malikiya Hinds, Mitchell J. Weiss, Wei Tong, John F. Tisdale, Gerd A. Blobel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 452-465 (2023)
Transcriptional enhancers can be in physical proximity of their target genes via chromatin looping. The enhancer at the β-globin locus (locus control region [LCR]) contacts the fetal-type (HBG) and adult-type (HBB) β-globin genes during correspondi
Externí odkaz:
https://doaj.org/article/32788d42c8a3431085e1147f913baa4b
Autor:
Lan Wang, Gajendra W. Suryawanshi, Shihyoung Kim, Xin Guan, Aylin C. Bonifacino, Mark E. Metzger, Robert E. Donahue, Sanggu Kim, Irvin S.Y. Chen
Publikováno v:
Heliyon, Vol 9, Iss 9, Pp e19435- (2023)
Selective T-cell depletion prior to cell or organ transplantation is considered a preconditioning regimen to induce tolerance and immunosuppression. An immunotoxin consisting of a recombinant anti-CD3 antibody conjugated with diphtheria toxin was use
Externí odkaz:
https://doaj.org/article/6d1b05ec6891474793ee47b9bea7ce1b
Autor:
Sandeep K. Srivastava, Lauren L. Truitt, Chuanfeng Wu, Adam Glaser, Daniel J. Nolan, Michael Ginsberg, Diego A. Espinoza, Samson Koelle, Idalia M. Yabe, Kyung-Rok Yu, Sogun Hong, Stephanie Sellers, Allen Krouse, Aylin Bonifacino, Mark Metzger, Pradeep K. Dagur, Robert E. Donahue, Cynthia E. Dunbar, Sandhya R. Panch
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 703-715 (2021)
Ex vivo hematopoietic stem and progenitor cell (HSPC) expansion platforms are under active development, designed to increase HSPC numbers and thus engraftment ability of allogeneic cord blood grafts or autologous HSPCs for gene therapies. Murine and
Externí odkaz:
https://doaj.org/article/f752637eb89a49feb1dc785c3084f549
Autor:
Naoya Uchida, Matthew M. Hsieh, Lydia Raines, Juan J. Haro-Mora, Selami Demirci, Aylin C. Bonifacino, Allen E. Krouse, Mark E. Metzger, Robert E. Donahue, John F. Tisdale
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Vectors used in gene therapy for hemoglobin disorders carry globin in a reverse-orientation to prevent the loss of key regulatory elements by RNA splicing, but this limits their efficiency. Here, the authors develop a vector carrying β-globin in a f
Externí odkaz:
https://doaj.org/article/10b9f0823d304489858931b8d82f9d3e
Autor:
Idalia M. Yabe, Lauren L. Truitt, Diego A. Espinoza, Chuanfeng Wu, Samson Koelle, Sandhya Panch, Marcus A.F. Corat, Thomas Winkler, Kyung-Rok Yu, So Gun Hong, Aylin Bonifacino, Allen Krouse, Mark Metzger, Robert E. Donahue, Cynthia E. Dunbar
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 11, Iss , Pp 143-154 (2018)
Gene therapies using integrating retrovirus vectors to modify hematopoietic stem and progenitor cells have shown great promise for the treatment of immune system and hematologic diseases. However, activation of proto-oncogenes via insertional mutagen
Externí odkaz:
https://doaj.org/article/af788885a60b4f71bbaeb35e5dd381a5
Autor:
Naoya Uchida, Linhong Li, Tina Nassehi, Claire M. Drysdale, Morgan Yapundich, Jackson Gamer, Juan J. Haro-Mora, Selami Demirci, Alexis Leonard, Aylin C. Bonifacino, Allen E. Krouse, N. Seth Linde, Cornell Allen, Madhusudan V. Peshwa, Suk See De Ravin, Robert E. Donahue, Harry L. Malech, John F. Tisdale
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100247- (2021)
Summary: Sickle cell disease (SCD) is caused by a 20A > T mutation in the β-globin gene. Genome-editing technologies have the potential to correct the SCD mutation in hematopoietic stem cells (HSCs), producing adult hemoglobin while simultaneously e
Externí odkaz:
https://doaj.org/article/8e26d04f631d48acaf229ebbbd2bce17
Autor:
Xing Fan, Chuanfeng Wu, Lauren L. Truitt, Diego A. Espinoza, Stephanie Sellers, Aylin Bonifacino, Yifan Zhou, Stefan F. Cordes, Allen Krouse, Mark Metzger, Robert E. Donahue, Rong Lu, Cynthia E. Dunbar
Publikováno v:
Haematologica, Vol 105, Iss 7 (2020)
The classical model of hematopoietic hierarchies is being reconsidered on the basis of data from in vitro assays and single cell expression profiling. Recent experiments suggested that the erythroid lineage might differentiate directly from multipote
Externí odkaz:
https://doaj.org/article/1f235fa8346348e9a8ac9d57a0b58d6a
Autor:
Lauren L. Truitt, Di Yang, Diego A. Espinoza, Xing Fan, Daniel R. Ram, Matilda J. Moström, Dollnovan Tran, Lesli M. Sprehe, R. Keith Reeves, Robert E. Donahue, Amitinder Kaur, Cynthia E. Dunbar, Chuanfeng Wu
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Recent functional, gene expression, and epigenetic studies have suggested the presence of a subset of mature natural killer (NK) cells responsible for maintaining NK cell memory. The lack of endogenous clonal markers in NK cells impedes understanding
Externí odkaz:
https://doaj.org/article/cd238f4bc5384c8ca993c13401ddbd33