Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Robert Durruthy-Durruthy"'
Autor:
Maggie S. Matern, Robert Durruthy-Durruthy, Onur Birol, Spyros Darmanis, Mirko Scheibinger, Andrew K. Groves, Stefan Heller
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112545- (2023)
Summary: An abundance of research has recently highlighted the susceptibility of cochleovestibular ganglion (CVG) neurons to noise damage and aging in the adult cochlea, resulting in hearing deficits. Furthering our understanding of the transcription
Externí odkaz:
https://doaj.org/article/edfacdabfdac43b3824d419aad9a89a5
Autor:
Robert Durruthy-Durruthy, Ethan D. Sperry, Margot E. Bowen, Laura D. Attardi, Stefan Heller, Donna M. Martin
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
The chromatin remodeling protein CHD7 is critical for proper formation of the mammalian inner ear. Humans with heterozygous pathogenic variants in CHD7 exhibit CHARGE syndrome, characterized by hearing loss and inner ear dysplasia, including abnormal
Externí odkaz:
https://doaj.org/article/8827bb90b6e24226bf46d7c43617fe3f
Publikováno v:
Cell Reports, Vol 11, Iss 9, Pp 1385-1399 (2015)
The organ of Corti harbors highly specialized sensory hair cells and surrounding supporting cells that are essential for the sense of hearing. Here, we report a single cell gene expression data analysis and visualization strategy that allows for the
Externí odkaz:
https://doaj.org/article/b93feb35202b440488057e76658e3a56
Autor:
Christopher S. Hourigan, Yuesheng Li, Patrick Burr, J. Philip McCoy, Pradeep K. Dagur, Aik Ooi, Shu Wang, Saurabh Gulati, Aaron Llanso, Robert Durruthy-Durruthy, Adam Sciambi, Catherine Lai, Christin B. DeStefano, Janet Valdez, Julie Thompson, Clifton L. Dalgard, Gauthaman Sukumar, Anthony R. Soltis, Matthew D. Wilkerson, Karolyn A. Oetjen, Katherine E. Lindblad, Katherine R. Calvo, Meghali Goswami, Gege Gui, Chidera Nosiri, Jack Ghannam, Laura W. Dillon
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583a4abaca0e1f1ff84cf805f24cfeb0
https://doi.org/10.1158/2643-3230.22543308.v1
https://doi.org/10.1158/2643-3230.22543308.v1
Autor:
Christopher S. Hourigan, Yuesheng Li, Patrick Burr, J. Philip McCoy, Pradeep K. Dagur, Aik Ooi, Shu Wang, Saurabh Gulati, Aaron Llanso, Robert Durruthy-Durruthy, Adam Sciambi, Catherine Lai, Christin B. DeStefano, Janet Valdez, Julie Thompson, Clifton L. Dalgard, Gauthaman Sukumar, Anthony R. Soltis, Matthew D. Wilkerson, Karolyn A. Oetjen, Katherine E. Lindblad, Katherine R. Calvo, Meghali Goswami, Gege Gui, Chidera Nosiri, Jack Ghannam, Laura W. Dillon
Genetic mutations associated with acute myeloid leukemia (AML) also occur in age-related clonal hematopoiesis, often in the same individual. This makes confident assignment of detected variants to malignancy challenging. The issue is particularly cru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4fa206442b59a1c6684b830d92d0762
https://doi.org/10.1158/2643-3230.c.6550209
https://doi.org/10.1158/2643-3230.c.6550209
Autor:
Alexander E. Perl, Catherine C. Smith, Martin Carroll, Neil P. Shah, Selina M. Luger, Aaron C. Logan, Safoora Deihimi, Lisa H.F. McGary, Cheryl A.C. Peretz, RosaAnna DeFilippis, Elisabeth A. Lasater, Saurabh Asthana, Christopher D. Watt, Robert Durruthy-Durruthy, Maurizio Pellegrino, Dennis J. Eastburn, Jennifer J.D. Morrissette, Eunice S. Wang, Jonathan Canaani, Timothy Ferng, Christine M. McMahon
Gilteritinib is a potent and selective FLT3 kinase inhibitor with single-agent clinical efficacy in relapsed/refractory FLT3-mutated acute myeloid leukemia (AML). In this context, however, gilteritinib is not curative, and response duration is limite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9342e80b4dcae04c4e27e5d1a7598d23
https://doi.org/10.1158/2159-8290.c.6548240.v1
https://doi.org/10.1158/2159-8290.c.6548240.v1
Autor:
Alexander E. Perl, Catherine C. Smith, Martin Carroll, Neil P. Shah, Selina M. Luger, Aaron C. Logan, Safoora Deihimi, Lisa H.F. McGary, Cheryl A.C. Peretz, RosaAnna DeFilippis, Elisabeth A. Lasater, Saurabh Asthana, Christopher D. Watt, Robert Durruthy-Durruthy, Maurizio Pellegrino, Dennis J. Eastburn, Jennifer J.D. Morrissette, Eunice S. Wang, Jonathan Canaani, Timothy Ferng, Christine M. McMahon
Supplementary Tables 1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe210e27d3ccf3dea02a649dd8d167e
https://doi.org/10.1158/2159-8290.22536788
https://doi.org/10.1158/2159-8290.22536788
Autor:
Alexander E. Perl, Catherine C. Smith, Martin Carroll, Neil P. Shah, Selina M. Luger, Aaron C. Logan, Safoora Deihimi, Lisa H.F. McGary, Cheryl A.C. Peretz, RosaAnna DeFilippis, Elisabeth A. Lasater, Saurabh Asthana, Christopher D. Watt, Robert Durruthy-Durruthy, Maurizio Pellegrino, Dennis J. Eastburn, Jennifer J.D. Morrissette, Eunice S. Wang, Jonathan Canaani, Timothy Ferng, Christine M. McMahon
Supplementary Figures S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7cefe956e48cc0c0783cbdb797c9d6
https://doi.org/10.1158/2159-8290.22536791.v1
https://doi.org/10.1158/2159-8290.22536791.v1
Autor:
Shu Wang, Robert Durruthy-Durruthy, Karolyn A. Oetjen, Jack Ghannam, Catherine Lai, Julie Thompson, Katherine E. Lindblad, Katherine R. Calvo, Adam Sciambi, Aaron Llanso, Gege Gui, Chidera Nosiri, Yuesheng Li, Aik Ooi, Janet Valdez, Meghali Goswami, Pradeep K. Dagur, Matthew D. Wilkerson, Anthony R. Soltis, Patrick Burr, Gauthaman Sukumar, Christopher S. Hourigan, Clifton L. Dalgard, Christin B. DeStefano, Laura W. Dillon, Saurabh Gulati, J. Philip McCoy
Publikováno v:
Cancer Discov
Genetic mutations associated with acute myeloid leukemia (AML) also occur in age-related clonal hematopoiesis, often in the same individual. This makes confident assignment of detected variants to malignancy challenging. The issue is particularly cru
Autor:
Alexander E. Perl, Mark Levis, Catherine C. Smith, Benjamin J. Huang, Cheryl A.C. Peretz, Jose Jacob, Lisa H F McGary, Robert Durruthy-Durruthy, Hunter Jackson, Tanya F Kumar
Publikováno v:
Blood advances, vol 5, iss 5
Blood Adv
Blood Adv
Key Points Single-cell sequencing exposes previously unmeasurable complexity of tumor heterogeneity and clonal evolution on quizartinib. Single-cell sequencing reveals on- and off-target mechanisms of resistance to quizartinib, which can preexist the