Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Robert Dunn-Dufault"'
Autor:
Miklos Feher, Robert Dunn-Dufault, Jonathan M. Schmidt, Julie Mercure, Gilles B. Tremblay, Markus G. Peter, Peter R. Redden, Martine Pagé
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:1389-1396
There is still a strong need for additional diversity and new chemical scaffolds to allow for the exploration of improved tissue selectivity and finding better selective estrogen receptor modulators (SERMs). Using a de novo design technology a diphen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572a017398ad92388afab7acb86efc33
https://doi.org/10.1016/s0968-0896(02)00647-8
https://doi.org/10.1016/s0968-0896(02)00647-8
Autor:
Martine Pagé, Aida Kalbakji, Markus G. Peter, Jonathan M. Schmidt, Gilles B. Tremblay, Julie Mercure, Peter R. Redden, Miklos Feher, Robert Dunn-Dufault
Publikováno v:
Journal of Medicinal Chemistry. 46:1408-1418
Although there are many estrogen receptor antagonists with improved tissue selectivity profiles compared with tamoxifen, optimal tissue selectivity has not yet been demonstrated. As such there is still a need for additional diversity and new chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7379b505242e2ac4dd96ec3242c119b
https://doi.org/10.1021/jm020536q
https://doi.org/10.1021/jm020536q
Publikováno v:
European Journal of Organic Chemistry. 2001:1643-1654
The preparation of a collection of alkyl, aryl, and 1-alkenyl 2-(trimethylsilyl)ethyl sulfoxides is outlined, using mostly vinyltrimethylsilane or 2-(trimethylsilyl)ethanesulfenyl chloride (5) as key starting materials. The 2-(trimethylsilyl)ethyl gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4931cb73d906a28e3db522f3faa34bf7
https://doi.org/10.1002/1099-0690(200105)2001:9<1643::aid-ejoc1643>3.0.co
https://doi.org/10.1002/1099-0690(200105)2001:9<1643::aid-ejoc1643>3.0.co
Publikováno v:
Nuclear Medicine and Biology. 27:803-807
A high effective specific activity (HESA) formulation of a biotin-containing (99m)Tc ligand [RP488: dimethyl-Gly-Ser-Cys(Acm)-Lys(Biotin)-Gly] conveniently prepared from solid phase was compared to a typical low effective specific activity (LESA) sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af3951640c437adb891054f78e66312
https://doi.org/10.1016/s0969-8051(00)00156-6
https://doi.org/10.1016/s0969-8051(00)00156-6
Autor:
Fupeng Ma, Miklos Feher, Michael A Plastina, Robert Dunn-Dufault, Peter R. Redden, Jonathan M. Schmidt, Sanjivanjit Bhal neé Basra, Gilles B. Tremblay
Publikováno v:
Bioorganicmedicinal chemistry. 13(5)
There is still a need for additional scaffolds to further explore tissue selectivity and improving efficacy of selective estrogen receptor modulators (SERMs). A series of hydroxyl substituted diphenylnaphthyl alkene ligands for the two estrogen recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413ce0cf27d9bfc48025f492943de3de
https://pubmed.ncbi.nlm.nih.gov/15776560
https://pubmed.ncbi.nlm.nih.gov/15776560
Autor:
Peter R. Redden, Markus G. Peter, Martine Pagé, Miklos Feher, Robert Dunn-Dufault, Gilles B. Tremblay, Jonathan M. Schmidt, Julie Mercure
Publikováno v:
Journal of medicinal chemistry. 46(8)
The identification of agents with specific antiproliferative or cytostatic activity against endothelial cells has significant value for the treatment of pathologies associated with angiogenesis, including solid tumors. Here, we describe a novel subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91be8c37f7ad02ed302084b2dcf40d89
https://pubmed.ncbi.nlm.nih.gov/12672229
https://pubmed.ncbi.nlm.nih.gov/12672229
Publikováno v:
Bioconjugate chemistry. 10(5)
A solid-phase technetium chelation chemistry was developed as a means of preparing (99m)Tc radiopharmaceuticals at high effective specific activity (HSA). Three peptidic N(3)S (99m)Tc ligands [mercaptoacetyl-Gly-Gly-Gly (MAG3), picolinyl-Ser-Cys-Gly-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565424f3d590bb7a78b854de2d96d5d7
https://pubmed.ncbi.nlm.nih.gov/10502350
https://pubmed.ncbi.nlm.nih.gov/10502350