Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Robert D. Winefield"'
Autor:
Zhen Zhang, Natasha E. Zachara, Chad Slawson, Udayan Apte, Ee Phie Tan, Bharat Bhushan, Robert D. Winefield, Sylvie E. Kandel, Steven R. McGreal, Chad Walesky, Margitta Lebofsky, Mitchell R. McGill, Hartmut Jaeschke
Publikováno v:
Toxicological Sciences. 162:599-610
Overdose of acetaminophen (APAP) results in acute liver failure. We have investigated the role of a posttranslational modification of proteins called O-GlcNAcylation, where the O-GlcNAc transferase (OGT) adds and O-GlcNAcase (OGA) removes a single β
Autor:
Robert D. Winefield, Rakesh K. Singh, James M. Backes, Ryan S. Funk, Janelle F. Ruisinger, Sylvie E. Kandel, Patrick M. Moriarty
Publikováno v:
Journal of Dietary Supplements. 15:343-351
Berberine is an isoquinoline alkaloid plant extract that is widely available as a dietary supplement in the United States and has demonstrated efficacy in the treatment of type 2 diabetes mellitus and dyslipidemia. Because of its increased use and pu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 3, p e0209726 (2019)
PLoS ONE, Vol 14, Iss 3, p e0209726 (2019)
The lanthanides (Ln3+), or rare earth elements, have proven to be useful tools for biomolecular NMR, X-ray crystallographic, and fluorescence analyses due to their unique 4f orbitals. However, their utility in biological applications has been limited
Autor:
Hartmut Jaeschke, Mitchell R. McGill, Robert D. Winefield, Douglas E. Rollins, Sarah F. Cook, Diana G. Wilkins, Matthew R. Sharpe, Yuchao Xie
Publikováno v:
Xenobiotica. 45:921-929
1. It has been suggested that acetaminophen (APAP)-protein adducts can be measured in circulation to diagnose APAP-induced liver injury. However, the full-time course of plasma adducts has not been studied specifically in early-presenting overdose pa
Autor:
Robert D. Winefield, Swetha Kaul, Anthonius A. M. Heemskerk, Todd D. Williams, Michael J. Caspers, Morris D. Faiman, Elinore F. McCance-Katz, Craig E. Lunte, Thomas E. Prisinzano
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 107:518-525
Disulfiram (DSF), a treatment for alcohol use disorders, has shown some clinical effectiveness in treating addiction to cocaine, nicotine, and pathological gambling. The mechanism of action of DSF for treating these addictions is unclear but it is un
Autor:
Mojtaba Olyaee, Parviz Gholami, Mitchell R. McGill, Robert D. Winefield, Steven C. Curry, William M. Lee, Matthew R. Sharpe, Benjamin L. Woolbright, Vincent S. Staggs, Hartmut Jaeschke
Publikováno v:
Toxicological Sciences. 142:436-444
Acetaminophen (APAP)-induced acute liver failure (ALF) remains a major clinical problem. Although a majority of patients recovers after severe liver injury, a subpopulation of patients proceeds to ALF. Bile acids are generated in the liver and accumu
Autor:
Lei Jiang, Mary L. Michaelis, Robert D. Winefield, Elias K. Michaelis, Jennifer L. Bean, Todd D. Williams, Misty D. Bechtel, Asma Zaidi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1838(5):1255-1265
Control of intracellular calcium concentrations ([Ca 2 + ] i ) is essential for neuronal function, and the plasma membrane Ca 2 + -ATPase (PMCA) is crucial for the maintenance of low [Ca 2 + ] i . We previously reported on loss of PMCA activity in br
Autor:
Lesya Novikova, Flavia C. Costa, Halyna Fedosyuk, Kenneth R. Peterson, Matthew P Parker, Robert D. Winefield, Carolina A. Braghini, Renee Neades
Publikováno v:
Experimental biology and medicine (Maywood, N.J.). 241(7)
Fetal hemoglobin is a major genetic modifier of the phenotypic heterogeneity in patients with sickle cell disease and certain β-thalassemias. Normal levels of fetal hemoglobin postnatally are approximately 1% of total hemoglobin. Patients who have h
Publikováno v:
Analytical Biochemistry. 395:217-223
Successful quantitative mass spectrometry (MS) requires strategies to link the mass spectrometer response to the analyte abundance, with the response being dependent on more factors than just analyte abundance. Label-dependent strategies rely on the
Autor:
Richard H. Himes, Travis B. Foland, Ruth Entwistle, Gerald H. Lushington, Robert D. Winefield
Publikováno v:
ChemMedChem. 3:1844-1847
Paclitaxel and a semi-synthetic analogue docetaxel (Scheme) are two taxane anti-tumor agents that are used against a number of cancers.[1] The taxanes bind to the β-subunit of the dimeric protein α,β-tubulin in microtubules in a 1:1 molar ratio, r