Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Robert D. Wilson"'
Autor:
Melissa E. Howard, Andrew W. Gibson, Alejandro Dieguez-Vazquez, Debra J. Wallace, Artis Klapars, Robert D. Wilson, Jeremy P. Scott, Peter R. Mullens, Andrew D. Gibb, Carl A. Baxter, Jaemoon Lee, Sarah E. Brewer, Stephen P. Keen, Ed Cleator, Nadine Bremeyer, Anthony Alorati, Kevin R. Campos, Matthew L. Maddess, Joseph J. Lynch, Jing Li
Publikováno v:
Organic Process Research & Development. 18:528-538
The development and execution of a practical asymmetric synthesis of the estrogen receptor beta selective agonist (8R,10aS)-6-(trifluoromethyl)-8,9,10,11-tetrahydro-8,10a-methanocyclohepta[1,2]indeno[4,5-d][1,2,3]triazol-7(3H)-one is described. The o
Autor:
Sarah E. Brewer, Ed Cleator, Debra J. Wallace, Paulo Avalle, Jeremy P. Scott, Andrew D. Gibb, Faye J. Sheen, Matthew M. Bio, Antony J. Davies, Gavin W. Stewart, Robert D. Wilson
Publikováno v:
Organic Process Research & Development. 17:1561-1567
The process development and multikilogram preparation of a TRPV1 antagonist, 1, is described. Pyrido[2,3-b]pyrazine 1 was prepared in a convergent manner by the coupling of two key fragments, glyoxal 2 and diamine 3. Glyoxal 2 was synthesized in six
Autor:
Paul Fernandez, Weifeng Hu, Peter Sajonz, Karel J. M. Brands, Jennifer R. Foley, Peter R. Mullens, Lushi Tan, George Zhou, Nadine Bremeyer, Robert D. Wilson, Sarah E. Brewer, Daniel J. Muzzio, Guoyue Zhou, Debra J. Wallace, Khateeta M. Emerson, Richard Desmond, Stephen P. Keen, Carl A. Baxter
Publikováno v:
Organic Process Research & Development. 15:831-840
Compound (1) a poly(ADP-ribose)polymerase (PARP) inhibitor has been made by a fit-for-purpose large-scale synthesis using either a classical resolution or chiral chromatographic separation. The development and relative merits of each route are discus
Autor:
Jeremy P. Scott, Mahbub Alam, Robert D. Wilson, Nadine Bremeyer, Adrian Goodyear, Thientu Lam, George Zhou
Publikováno v:
Organic Process Research & Development. 15:1116-1123
The development of a practical synthesis of the hepatitis C virus polymerase inhibitor 1 was necessary to support preclinical safety and human clinical studies. Significant challenges face the proc...
Autor:
Robert D. Wilson, Matthew M. Bio, Antony J. Davies, Faye J. Sheen, Andy Lawrence, Gavin W. Stewart, Ed Cleator, Simon E. Hamilton
Publikováno v:
Tetrahedron. 65:8950-8955
The development of a synthetically useful, regioselective cross-coupling of 2,4-diaminopyridines with aryl and heteroaryl halides is reported. Selectivity for coupling through either amine is controlled by a simple change in the reaction conditions.
Autor:
Robert D. Wilson, George Zhou, Antony J. Davies, Gavin W. Stewart, Karel M. J. Brands, David Hands, Steven F. Oliver, Michael S. Ashwood, Robert A. Reamer, Ed Cleator, Matthew M. Bio, Ulf-H. Dolling, Khateeta M. Emerson, Faye J. Sheen, Arlene E. Mckeown, Andrew D. Gibb
Publikováno v:
Organic Process Research & Development. 13:543-547
A practical and efficient synthesis of 1,4,5,6-tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole, 1, is described. A new one-pot process has been developed, starting from the commercially availa...
Autor:
Ed Cleator, Karel M. J. Brands, Antony J. Davies, Matthew M. Bio, Christopher Wise, Anthony Alorati, Robert D. Wilson
Publikováno v:
Organic Process Research & Development. 11:637-641
An efficient synthesis of 1R,5S-bicyclo[3.1.0]hexan-2-one from (R)-1,2-epoxyhex-5-ene is described. Development of a catalytic intramolecular cyclopropanation of (R)-1,2-epoxyhex-5-ene gives the key homochiral bicycle[3.1.0]hexan-1-ol, which is then
Autor:
Antony J. Davies, Karel M. J. Brands, Sarah E. Brewer, Robert D. Wilson, Jeremy P. Scott, Andrew D. Gibb, Faye J. Sheen, Ulf-H. Dolling, David Hands, Stephen P. Keen, Robert A. Reamer, Steven F. Oliver
Publikováno v:
The Journal of Organic Chemistry. 71:3086-3092
A practical asymmetric synthesis of the gamma-secretase inhibitor (-)-1 is described. As the key transformation, a highly diastereoselective intramolecular nitrile oxide cycloaddition forms the hexahydrobenzisoxazole core of 3 in four operations. Oth
Autor:
Cameron J. Cowden, Ian F. Cottrell, Khateeta M. Emerson, Robert D. Wilson, Antony J. Davies, Ulf H. Dolling, David Hands, Andrew D. Gibb, Michael S. Ashwood, and Debra J. Wallace, Ramon J. Alabaster
Publikováno v:
Organic Process Research & Development. 8:192-200
A scaleable route to 2-{3-[(2,2-difluoro-2-(2-pyridyl)ethyl)amino]-6-chloro-2-oxohydropyrazinyl}-N-[(3-fluoro(2-pyridyl))methyl]acetamide 1 is described in which various scaleup issues were addressed to provide a safe, efficient, and robust route for
Autor:
Robert D. Wilson, Brandon Cales
Publikováno v:
Communications of the IIMA. 8