Zobrazeno 1 - 10
of 294
pro vyhledávání: '"Robert D. Toto"'
Autor:
Glenn M. Chertow, Hiddo Lambers Heerspink, Patrick B. Mark, Jamie P. Dwyer, Michal Nowicki, David C. Wheeler, Ricardo Correa-Rotter, Peter Rossing, Robert D. Toto, Anna Maria Langkilde, Niels Jongs
Publikováno v:
Glomerular Diseases (2024)
Introduction Despite the provision of renin-angiotensin-aldosterone-system inhibitors and immunosuppressive therapies, membranous nephropathy often progresses to end-stage kidney disease (ESKD). The objective of this prespecified analysis was to asse
Externí odkaz:
https://doaj.org/article/f7c6397ab9254160bd340782cae6b634
Autor:
Silvia Ferrè, Yu-Lun Liu, Joshua W. Lambert, Ronit Katz, Fabiola G. Gianella, David A. Drew, Michael G. Shlipak, Orson W. Moe, Joachim H. Ix, Robert D. Toto, Javier A. Neyra
Publikováno v:
Kidney Medicine, Vol 5, Iss 6, Pp 100634- (2023)
Rationale and Objective: Serum magnesium levels have been inversely yet inconsistently associated with cardiovascular (CV) outcomes. In this study, we examined the association of serum magnesium levels with CV outcomes in the Systolic Blood Pressure
Externí odkaz:
https://doaj.org/article/bb693f4ef1c04a4e8628f6df1154d753
Autor:
Glenn M. Chertow, Ricardo Correa‐Rotter, Priya Vart, Niels Jongs, John J. V. McMurray, Peter Rossing, Anna Maria Langkilde, C. David Sjöström, Robert D. Toto, David C. Wheeler, Hiddo J. L. Heerspink
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 9 (2023)
Background The DAPA‐CKD (Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease) trial (NCT03036150) demonstrated that dapagliflozin reduced the risk of kidney and cardiovascular events in patients with chronic kidney disease an
Externí odkaz:
https://doaj.org/article/9826f32decaf40029c4ae4917e251524
Autor:
Michael Crompton, Joanne K. Ferguson, Raina D. Ramnath, Karen L. Onions, Anna S. Ogier, Monica Gamez, Colin J. Down, Laura Skinner, Kitty H. Wong, Lauren K. Dixon, Judit Sutak, Steven J. Harper, Paola Pontrelli, Loreto Gesualdo, Hiddo L. Heerspink, Robert D. Toto, Gavin I. Welsh, Rebecca R. Foster, Simon C. Satchell, Matthew J. Butler
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
The glomerular endothelial glycocalyx (GEnGlx) forms the first part of the glomerular filtration barrier. Previously, we showed that mineralocorticoid receptor (MR) activation caused GEnGlx damage and albuminuria. In this study, we investigated wheth
Externí odkaz:
https://doaj.org/article/359f2aff3fef4349ad8f0cd82c87577a
Serum IL-17 levels are higher in critically ill patients with AKI and associated with worse outcomes
Autor:
Jason A. Collett, Victor Ortiz-Soriano, Xilong Li, Alexander H. Flannery, Robert D. Toto, Orson W. Moe, David P. Basile, Javier A. Neyra
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-9 (2022)
Abstract Background Interleukin-17 (IL-17) antagonism in rats reduces the severity and progression of AKI. IL-17-producing circulating T helper-17 (TH17) cells is increased in critically ill patients with AKI indicating that this pathway is also acti
Externí odkaz:
https://doaj.org/article/7e1dfbca955b4bc7b20819cfdf01d435
Autor:
Michele Provenzano, Niels Jongs, Priya Vart, Bergur V. Stefánsson, Glenn M. Chertow, Anna Maria Langkilde, John J.V. McMurray, Ricardo Correa-Rotter, Peter Rossing, C. David Sjöström, Robert D. Toto, David C. Wheeler, Hiddo J.L. Heerspink
Publikováno v:
Kidney International Reports, Vol 7, Iss 3, Pp 436-443 (2022)
Introduction: Mineralocorticoid receptor antagonists (MRAs) and sodium–glucose cotransporter-2 (SGLT2) inhibitors reduce the risk of kidney failure in chronic kidney disease (CKD). We performed an analysis of the Dapagliflozin and Prevention of Adv
Externí odkaz:
https://doaj.org/article/1ea3200adb9746dca4e6abb643d67f2e
Autor:
Alexander H. Flannery, Victor Ortiz-Soriano, Xilong Li, Fabiola G. Gianella, Robert D. Toto, Orson W. Moe, Prasad Devarajan, Stuart L. Goldstein, Javier A. Neyra
Publikováno v:
Critical Care, Vol 25, Iss 1, Pp 1-8 (2021)
Abstract Background Preliminary studies have suggested that the renin-angiotensin system is activated in critical illness and associated with mortality and kidney outcomes. We sought to assess in a larger, multicenter study the relationship between s
Externí odkaz:
https://doaj.org/article/a916748c93944390b50042431c2bf451
Autor:
Bradley A. Warady, Rajiv Agarwal, Sripal Bangalore, Arlene Chapman, Adeera Levin, Peter Stenvinkel, Robert D. Toto, Glenn M. Chertow
Publikováno v:
Kidney Medicine, Vol 2, Iss 5, Pp 639-649 (2020)
Alport syndrome affects up to 60,000 people in the United States. The proposed reclassification of thin basement membrane nephropathy and some cases of focal segmental glomerulosclerosis as Alport syndrome could substantially increase the affected po
Externí odkaz:
https://doaj.org/article/2c5fd47a1b1c4ef5b389452b3235db65
Autor:
Alexander H. Flannery, Xilong Li, Natalie L. Delozier, Robert D. Toto, Orson W. Moe, Jerry Yee, Javier A. Neyra
Publikováno v:
Kidney Medicine, Vol 3, Iss 4, Pp 507-514.e1 (2021)
Rationale & Objective: Sepsis-associated acute kidney injury often leads to acute kidney disease (AKD), predisposing patients to long-term complications such as chronic kidney disease (CKD), kidney failure with replacement therapy (KFRT), or mortalit
Externí odkaz:
https://doaj.org/article/be601320240e4b9db02d2875e8d1044f
Autor:
Javier A. Neyra, Ming-Chang Hu, Abu Minhajuddin, Geoffrey E. Nelson, Syed A. Ahsan, Robert D. Toto, Michael E. Jessen, Orson W. Moe, Amanda A. Fox
Publikováno v:
Kidney International Reports, Vol 4, Iss 8, Pp 1131-1142 (2019)
Background: Cardiac surgery–associated acute kidney injury (AKI) is associated with increased morbidity and mortality. We examined the utility of combining biomarkers of kidney function loss (serum cystatin C) and kidney tubular damage (urine neutr
Externí odkaz:
https://doaj.org/article/7c147e81f23244c489099cf72381517d