Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Robert D. Selliah"'
AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey
Autor:
Raymond E. Conrow, Mark R. Hellberg, David Earnest, Gary W. Williams, Pete Delgado, W. Dennis Dean, Najam A. Sharif, Peter G. Klimko, Michael S. Gaines, Karen S. Haggard, Robert D. Selliah, Marsha A. McLaughlin, Daniel Scott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4525-4528
A series of 11-oxa prostaglandin analogs was evaluated for FP receptor binding and activation. Several compounds having aryloxy-terminated lower chains were found to be potent agonists. Topical ocular dosing of AL-12182, the isopropyl ester prodrug o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eaa7f878c1b411bce26660af3350532
https://doi.org/10.1016/j.bmcl.2004.06.037
https://doi.org/10.1016/j.bmcl.2004.06.037
Autor:
John C. Gilbert, Robert D. Selliah
Publikováno v:
Research on Chemical Intermediates. 22:91-101
The highly hindered β-hydroxyester 3 fails to oxidize under the usual Swern reaction conditions, whereas closely related compounds react successfully. Swern oxidation of 3 occurs if the work-up conditions are modified or if diazabicycloundecane (DBU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb98ab8186bdf189b1776572db465dfa
https://doi.org/10.1163/156856796x00548
https://doi.org/10.1163/156856796x00548
Autor:
Robert D. Selliah, John C. Gilbert
Publikováno v:
Tetrahedron. 50:1651-1664
A convergent route for the enantioselective synthesis of trichothecenes is described. A key step in the synthetic sequence is an Ireland-Claisen rearrangement that occurs with total facial selectivity and high diastereoselectivity. The relative stere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5f6e2dd687501d594277f98e6739106
https://doi.org/10.1016/s0040-4020(01)80841-3
https://doi.org/10.1016/s0040-4020(01)80841-3
Autor:
John C. Gilbert, Robert D. Selliah
Publikováno v:
The Journal of Organic Chemistry. 58:6255-6265
An enantioselective synthesis of trichodiene 1 has been accomplished. The key bond between the vicinal quaternary centers is formed by way of an Ireland-Claisen rearrangement of the ketene silyl acetal 24. The rearrangement occurs with complete facia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9de31fa98d005f94c94056cdb5f40d42
https://doi.org/10.1021/jo00075a020
https://doi.org/10.1021/jo00075a020
Autor:
Robert D. Selliah, John C. Gilbert
Publikováno v:
ChemInform. 25
An enantioselective synthesis of trichodiene 1 has been accomplished. The key bond between the vicinal quaternary centers is formed by way of an Ireland-Claisen rearrangement of the ketene silyl acetal 24. The rearrangement occurs with complete facia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::166ec30586508ffc47da7c351779de95
https://doi.org/10.1002/chin.199410235
https://doi.org/10.1002/chin.199410235
Autor:
Robert D. Selliah, John C. Gilbert
Publikováno v:
ChemInform. 25
A convergent route for the enantioselective synthesis of trichothecenes is described. A key step in the synthetic sequence is an Ireland-Claisen rearrangement that occurs with total facial selectivity and high diastereoselectivity. The relative stere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::374c588cbfe08cd2401797c074699f18
https://doi.org/10.1002/chin.199422218
https://doi.org/10.1002/chin.199422218
Autor:
Robert D. Selliah, John C. Gilbert
Publikováno v:
Tetrahedron Letters. 33:6259-6262
Total synthesis of (+)−15-hydroxytrichotech-9,12-diene (4) has been accomplished in 16 steps and in 5.5% overall yield from the optically active β-hydroxyester 9. Creation of the vicinal quaternary centers resulted from a highly enantio- and diast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fb71e987eb106a08407abbc137dc58e
https://doi.org/10.1016/s0040-4039(00)60947-4
https://doi.org/10.1016/s0040-4039(00)60947-4
Autor:
Angela C. Kothe, Alan L. Weiner, Verney L. Sallee, N.A. Sharif, Evan P. Kyba, Stella M. Robertson, John E Bishop, Lewis H. Silver, Michael V.W. Bergamini, Paul W Zinke, Mark R. Hellberg, Peter G. Klimko, Louis Desantis, Joseph M. deFaller, Alberta A Davis, Thomas R. Dean, George Barnes, Theresa A. Landry, Marsha A. McLaughlin, Robert D. Selliah, Russell M. Andrew, E. Kenneth Sullivan
Publikováno v:
Survey of ophthalmology. 47
The structure-activity studies that led to the identification of travoprost, a highly selective and potent FP prostaglandin analog, and AL-6598, a DP prostaglandin analog, are detailed. In both series, the 1-alcohol analogs are very effective and are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc76a86c3a5467435cc63605dec04dc0
https://pubmed.ncbi.nlm.nih.gov/12204698
https://pubmed.ncbi.nlm.nih.gov/12204698
Autor:
Robert D. Selliah, Peter G. Klimko, W. Dennis Dean, Mark R. Hellberg, Pierce David R, Gary W. Williams, Verney L. Sallee, Raymond E. Conrow, John E Bishop, Paul W Zinke, Julie Y. Crider, Marsha A. McLaughlin, Kevin A DeWolf, Bryon S. Severns, Najam A. Sharif, Steven J. Sproull
Publikováno v:
Bioorganicmedicinal chemistry. 10(6)
A series of prostaglandin DP agonists containing a 3-oxa-15-cyclohexyl motif was synthesized and evaluated in several in vitro and in vivo biological assays. The reference compound ZK 118.182 (9beta-chloro-15-cyclohexyl-3-oxa-omega-pentanor PGF(2alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76c32eb96beda8943413a7f7a4fcfd9
https://pubmed.ncbi.nlm.nih.gov/11937363
https://pubmed.ncbi.nlm.nih.gov/11937363
Autor:
Robert D. Selliah
Publikováno v:
Journal of the American Chemical Society. 123:6463-6463
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::180783045f56b8a74d14c612f447891b
https://doi.org/10.1021/ja004756+
https://doi.org/10.1021/ja004756+