Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Robert D. Purves"'
Autor:
Charles W. McLaughlin, Robert D. Purves, Anthony D. C. Macknight, David A. Carré, Mortimer M. Civan, Claire H. Mitchell, David Peart, Kim Peterson-Yantorno
Publikováno v:
American Journal of Physiology-Cell Physiology. 281:C865-C875
The β-adrenergic antagonist timolol reduces ciliary epithelial secretion in glaucomatous patients. Whether inhibition is mediated by reducing cAMP is unknown. Elemental composition of rabbit ciliary epithelium was studied by electron probe X-ray mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d82d1b8335fa4ac50f00dd10fb7e1a7
https://doi.org/10.1152/ajpcell.2001.281.3.c865
https://doi.org/10.1152/ajpcell.2001.281.3.c865
Autor:
David Peart, Anthony D. C. Macknight, Robert D. Purves, Mortimer M. Civan, David A. Carré, J. M. Bowler
Publikováno v:
Experimental Eye Research. 62:131-140
Rabbit iris-ciliary bodies were preincubated in control and experimental Ringer's solutions before quick freezing, cryosectioning, dehydration and electron probe X-ray microanalysis. After preincubation in a baseline bicarbonate-free Cl- Ringer's sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d77cc55bf5a6baaf9199d8861bef2f
https://doi.org/10.1006/exer.1996.0017
https://doi.org/10.1006/exer.1996.0017
Autor:
Robert D. Purves
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 24:79-101
When the two-compartment model with absorption is fitted to data by nonlinear least squares, in general six different outcomes can be obtained, arising from permutation of the three exponential rate constants. The existence of multiple solutions in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323e444c241e6f926b001bf08d22d9a9
https://doi.org/10.1007/bf02353511
https://doi.org/10.1007/bf02353511
Autor:
Robert D. Purves
Publikováno v:
Journal of Pharmaceutical Sciences. 84:71-74
Numerical inversion of the Laplace transform is a useful technique for pharmacokinetic modeling and parameter estimation when the model equations can be solved in the Laplace domain but the solutions cannot be inverted back to the time domain. The ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b35793a1d5034263044cf79cc5430ef
https://doi.org/10.1002/jps.2600840117
https://doi.org/10.1002/jps.2600840117
Autor:
Robert D. Purves
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 20:211-226
Eleven numerical methods for estimation of AUC (including 4 new methods) and 22 methods for AUMC (including 8 new methods) were tested on large simulated noisy datasets representing bolus, oral and infusion concentration-time profiles. Some methods w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674cdc7bb5f9863855068ce2ddd4484d
https://doi.org/10.1007/bf01062525
https://doi.org/10.1007/bf01062525
Autor:
Robert D. Purves
Publikováno v:
Journal of Pharmaceutical Sciences. 82:1064-1066
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a99f04697c2d443a88962ab4629ff538
https://doi.org/10.1002/jps.2600821011
https://doi.org/10.1002/jps.2600821011
Autor:
David Peart, S. Zellhuber-Mcmillan, Mortimer M. Civan, Robert D. Purves, Anthony D. C. Macknight, C.W. McLaughlin
Publikováno v:
The Journal of membrane biology. 182(3)
Experiments were performed to determine whether the transport properties of the ciliary epithelium vary over different regions. Rabbit iris-ciliary bodies were incubated under experimental or control conditions for 30 min before quick freezing, cryos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe284e7b9e23abf93b21468e75fcd53
https://pubmed.ncbi.nlm.nih.gov/11547344
https://pubmed.ncbi.nlm.nih.gov/11547344
Autor:
David Peart, Robert D. Purves, Anthony D. C. Macknight, Mortimer M. Civan, Charles W. McLaughlin, David A. Carré
Publikováno v:
Clinical and experimental pharmacologyphysiology. 27(1-2)
SUMMARY 1. Glaucoma is a worldwide disease affecting approximately 1–2% of the population aged over 35 years in industrial countries and is a major cause of blindness. 2. Glaucoma is usually associated with an increased intra-ocular pressure reflec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3d66d093a5b0e4318b0099609a0f76
https://pubmed.ncbi.nlm.nih.gov/10696536
https://pubmed.ncbi.nlm.nih.gov/10696536
Publikováno v:
The Journal of Membrane Biology. 145
Toad urinary bladder epithelial cells were incubated in Na Ringer's with the serosal surface of the epithelium clamped at either +50 mV, 0 mV (short-circuited) or -50 mV with respect to the mucosal surface. Following incubation, portions of tissue we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e61108d0f62dea9fb0eaec2478fcd7e
https://doi.org/10.1007/bf00237375
https://doi.org/10.1007/bf00237375
Publikováno v:
The Journal of Membrane Biology. 142
Relationships between short-circuit current (I sc), cell Cl and the mechanism(s) of Cl accumulation in toad bladder epithelial cells were investigated. In serosal Cl-free gluconate Ringer, 80% of the cell Cl (measured by x-ray microanalysis) was lost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53170e5ced79af8c00ff2c980eee48be
https://doi.org/10.1007/bf00233379
https://doi.org/10.1007/bf00233379