Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Robert D. Kirkton"'
Autor:
Kevin M. Nash, PhD, Brian A. Boe, MD, Sergio A. Carrillo, MD, Andrew Harrison, AS, ARRT, Ryuma Iwaki, MD, John Kelly, MD, Robert D. Kirkton, PhD, Ramkumar Krishnamurthy, PhD, Jeffrey H. Lawson, MD, PhD, Yuichi Matsuzaki, MD, PhD, Heather L. Prichard, PhD, Kejal Shah, MD, Toshiharu Shinoka, MD, PhD, Christopher K. Breuer, MD
Publikováno v:
JTCVS Open, Vol 15, Iss , Pp 433-445 (2023)
Objectives: Palliative treatment of cyanotic congenital heart disease (CCHD) uses systemic-to-pulmonary conduits, often a modified Blalock–Taussig–Thomas shunt (mBTTs). Expanded polytetrafluoroethylene (ePTFE) mBTTs have associated risks for thro
Externí odkaz:
https://doaj.org/article/dbfdc050eeff4efa8d573ed68bec9a99
Autor:
Juan Wang, PhD, Shelby K.F. Blalock, BS, Garyn S. Levitan, BS, Heather L. Prichard, PhD, Laura E. Niklason, MD, PhD, Robert D. Kirkton, PhD
Publikováno v:
JVS - Vascular Science, Vol 4, Iss , Pp 100120- (2023)
Objective: Synthetic expanded polytetrafluoroethylene (ePTFE) grafts are known to be susceptible to bacterial infection. Results from preclinical and clinical studies of bioengineered human acellular vessels (HAVs) have shown relatively low rates of
Externí odkaz:
https://doaj.org/article/e0b512fc3d894edb9a772e6e3fb74e7c
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Restoring lost excitability of injured tissue is a paramount of regenerative medicine. By using a combined expression of bacterial voltage-gated Na+ channel, Kir2.1, and connexin-43 in non-excitable human fibroblasts, here the authors generate excita
Externí odkaz:
https://doaj.org/article/01169a26b7fb41869b421987bafb38d4
Autor:
Robert D. Kirkton, J. Devin B. Watson, Robert Houston, Heather L. Prichard, Laura E. Niklason, Todd E. Rasmussen
Publikováno v:
Journal of Trauma and Acute Care Surgery.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3c6e91122fabe81eb82e5cc5282b99a
https://doi.org/10.1097/ta.0000000000003974
https://doi.org/10.1097/ta.0000000000003974
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 1, p e1005342 (2017)
To understand how excitable tissues give rise to arrhythmias, it is crucially necessary to understand the electrical dynamics of cells in the context of their environment. Multicellular monolayer cultures have proven useful for investigating arrhythm
Externí odkaz:
https://doaj.org/article/77691330b04346f385f93b8e067b9511
Autor:
Nicolas Christoforou, Malathi Chellappan, Andrew F Adler, Robert D Kirkton, Tianyi Wu, Russell C Addis, Nenad Bursac, Kam W Leong
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63577 (2013)
Transient overexpression of defined combinations of master regulator genes can effectively induce cellular reprogramming: the acquisition of an alternative predicted phenotype from a differentiated cell lineage. This can be of particular importance i
Externí odkaz:
https://doaj.org/article/36961434f43a4058af0d11d6d51700d2
Publikováno v:
Nature Protocols. 13:927-945
We describe a two-stage protocol to generate electrically excitable and actively conducting cell networks with stable and customizable electrophysiological phenotypes. Using this method, we have engineered monoclonally derived excitable tissues as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2492e11e2666551f786596a5c91196e
https://doi.org/10.1038/nprot.2018.016
https://doi.org/10.1038/nprot.2018.016
Autor:
Jeffrey H. Lawson, Maribel Santiago-Maysonet, Heather L. Prichard, Laura E. Niklason, Robert D. Kirkton, Shannon L. M. Dahl
Publikováno v:
Journal of Surgical Research. 221:143-151
Background Synthetic expanded polytetrafluorethylene (ePTFE) grafts are routinely used for vascular repair and reconstruction but prone to sustained bacterial infections. Investigational bioengineered human acellular vessels (HAVs) have shown clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e92677bfe8eba2eb2605b7f4cb72a66
https://doi.org/10.1016/j.jss.2017.08.035
https://doi.org/10.1016/j.jss.2017.08.035
Autor:
Jakub Turek, Rabih Samad, Tomaz Zubilewicz, Jeffrey H. Lawson, Laura E. Niklason, Stanisław Przywara, Shawn M. Gage, Alison Pilgrim, Marek Iłżecki, Wojcieh Witkiewicz, Heather L. Prichard, Norbert Zapotoczny, Piotr Gutowski, Robert D. Kirkton, Malgorzata Guziewicz, Bill Tente, Arkadiusz Kazimierczak
Publikováno v:
Journal of vascular surgery. 72(4)
Objective Vascular conduit is essential for arterial reconstruction for a number of conditions, including trauma and atherosclerotic occlusive disease. We have developed a tissue-engineered human acellular vessel (HAV) that can be manufactured, store
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210f1dbe3f417e45a67c6eb6559254c1
https://pubmed.ncbi.nlm.nih.gov/32972585
https://pubmed.ncbi.nlm.nih.gov/32972585
Autor:
Heather L. Prichard, Maribel Santiago-Maysonet, Laura E. Niklason, William E. Tente, Shannon L. M. Dahl, Robert D. Kirkton, Jeffrey H. Lawson
Publikováno v:
Sci Transl Med
Traditional vascular grafts constructed from synthetic polymers or cadaveric human or animal tissues support the clinical need for readily available blood vessels, but often come with associated risks. Histopathological evaluation of these materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0db22d3dd113816a04021a7d742c90
https://pubmed.ncbi.nlm.nih.gov/30918113
https://pubmed.ncbi.nlm.nih.gov/30918113