Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Robert D. Junkins"'
Autor:
Matthew D. Gallovic, Robert D. Junkins, Adam M. Sandor, Erik S. Pena, Christopher J. Sample, Ariel K. Mason, Leslee C. Arwood, Rebecca A. Sahm, Eric M. Bachelder, Kristy M. Ainslie, Gregory D. Sempowski, Jenny P.-Y. Ting
Publikováno v:
J Control Release
The COVID-19 pandemic highlights the need for effective vaccines against respiratory viruses. An ideal vaccine should induce robust and long-lasting responses with high manufacturing scalability. We used an adjuvant comprised of a Stimulator of Inter
Regulator of calcineurin 1 differentially regulates TLR-dependent MyD88 and TRIF signaling pathways.
Autor:
Zheng Pang, Robert D Junkins, Renee Raudonis, Adam J MacNeil, Craig McCormick, Zhenyu Cheng, Tong-Jun Lin
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197491 (2018)
Toll-like receptors (TLRs) recognize the conserved molecular patterns in microorganisms and trigger myeloid differentiation primary response 88 (MyD88) and/or TIR-domain-containing adapter-inducing interferon-β (TRIF) pathways that are critical for
Externí odkaz:
https://doaj.org/article/441ddd81542b4327889eecec03a216e7
The AAA-ATPase p97 facilitates degradation of apolipoprotein B by the ubiquitin-proteasome pathways⃞
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 10, Pp 2149-2160 (2008)
The ATPase associated with various cellular activities (AAA-ATPase) p97 (p97) has been implicated in the retrotranslocation of target proteins for delivery to the cytosolic proteasome during endoplasmic reticulum-associated degradation (ERAD). Apolip
Externí odkaz:
https://doaj.org/article/0a58415e84ce465abb8e3f67bff18dcf
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72263 (2013)
Pseudomonas aeruginosa is an opportunistic bacterial pathogen which is the leading cause of morbidity and mortality among cystic fibrosis patients. Although P. aeruginosa is primarily considered an extacellular pathogen, recent reports have demonstra
Externí odkaz:
https://doaj.org/article/d84026e019fd44a2aad9f8d788297ead
Autor:
Rachid El Morabiti, Karen V. Swanson, Jenny P.-Y. Ting, Glen N. Barber, Cathryn J. Kurkjian, Elizabeth Holley-Guthrie, Avani A. Pendse, Robert D. Junkins, Chris A. Benedict, Alex Petrucelli
Publikováno v:
The Journal of Experimental Medicine
In this issue of JEM, Swanson et al. report an unanticipated role for cGAMP in priming and activation of inflammasomes in addition to its well-characterized function as an endogenous second messenger inducing type I interferons in the cytosolic DNA-s
Autor:
Wei-Min Chen, Robert D. Junkins, Craig McCormick, Tong-Jun Lin, Adam J. MacNeil, Zhenyu Cheng, Zheng Pang
Publikováno v:
Journal of Leukocyte Biology. 102:1461-1469
Infection with the opportunistic pathogen Pseudomonas aeruginosa is effectively controlled through tightly coordinated inflammation in healthy individuals. Dysregulated inflammation in cystic fibrosis greatly increases susceptibility to P. aeruginosa
Autor:
Rebekah Watkins-Schulz, Pamela Tiet, Cole J. Batty, Jenny P.-Y. Ting, Robert D. Junkins, Kristy M. Ainslie, Eric M. Bachelder, Matthew D. Gallovic
Immunotherapies have significantly improved cancer patient survival, but response rates are still limited. Thus, novel formulations are needed to expand the breadth of immunotherapies. Pathogen associated molecular patterns (PAMPs) can be used to sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd78adbd5ed86ac6967ebe959deb6e3
https://europepmc.org/articles/PMC6594365/
https://europepmc.org/articles/PMC6594365/
Autor:
Jenny P.-Y. Ting, Kristy M. Ainslie, Robert D. Junkins, Hong Yuan, Clément N. David, Lei Miao, Ning Cheng, Qi Liu, David B. Darr, Rebekah Watkins-Schulz, Karen P. McKinnon, Eric M. Bachelder, Stephanie A. Montgomery, Leaf Huang, Brandon M. Johnson, Kevin J. Peine
Triple-negative breast cancer (TNBC) has few therapeutic options, and alternative approaches are urgently needed. Stimulator of IFN genes (STING) is becoming an exciting target for therapeutic adjuvants. However, STING resides inside the cell, and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8528ecd8b5c8b085ad49aec16818fc5d
https://europepmc.org/articles/PMC6302949/
https://europepmc.org/articles/PMC6302949/
Autor:
Jenny P.-Y. Ting, Gregory D. Sempowski, Brandon M. Johnson, Robert D. Junkins, Kristy M. Ainslie, Monica M. Johnson, Eric M. Bachelder, Matthew D. Gallovic, Andrew N. Macintyre, Michael A. Collier
Vaccines are the most effective tool for preventing infectious diseases; however, subunit vaccines, considered the safest type, suffer from poor immunogenicity and require adjuvants to create a strong and sustained immune response. As adjuvants, path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23965ef319456d7ae02e63fee4c1a6a5
https://europepmc.org/articles/PMC6261357/
https://europepmc.org/articles/PMC6261357/
Autor:
Zheng, Pang, Robert D, Junkins, Adam J, MacNeil, Craig, McCormick, Zhenyu, Cheng, Wei-Min, Chen, Tong-Jun, Lin
Publikováno v:
Journal of leukocyte biology. 102(6)
Infection with the opportunistic pathogen