Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Robert D. Hutchins"'
Autor:
Ramesh Kakarla, James C. Sutton, Shirong Zhu, Robert D. Hutchins, Samuel Gerritz, Bogumila Rachwal, Zheming Ruan, Daniel L. Cheney, Michael J. Sofia, Shuhao Shi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6477-6480
The solid-phase synthesis of a library based on an unusual biphenyl-containing trypsin-like serine protease inhibitor is described. Key to this effort was the synthesis of a highly functionalized aryl boronic acid reagent which required the developme
Autor:
David S. Nirschl, Stanley R. Krystek, James C. Sutton, Daniel M. Camac, Ramakrishna Seethala, Jeffrey A. Robl, Rajasree Golla, James J. Li, Robert Zahler, Paul E. Morin, Haixia Wang, Rebecca A. Smirk, Cooper Christopher B, Mary Ellen K. Salyan, Katy Van Kirk, Zhengping Ma, Steven Sheriff, David A. Gordon, Ligaya M. Simpkins, Zheming Ruan, Robert D. Hutchins, Brian Carpenter, Akbar Nayeem, Lawrence G. Hamann, Shung C. Wu
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(11)
Several series of pyridine amides were identified as selective and potent 11beta-HSD1 inhibitors. The most potent inhibitors feature 2,6- or 3,5-disubstitution on the pyridine core. Various linkers (CH(2)SO(2), CH(2)S, CH(2)O, S, O, N, bond) between
Autor:
Robert D. Hutchins
Publikováno v:
Dialogue: A Journal of Mormon Thought. 16:154-155