Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Robert D. Hoeldtke"'
Autor:
Erica Ghareeb, Robert D. Hoeldtke, Knox Van Dyke, David H. Van Thiel, Chris Van Dyke, Mark Van Dyke
Publikováno v:
ISRN Toxicology
Since oxidative/nitrosative stress cause diabetes, can we prevent this chemistry generating the disease? Streptozotocin causes diabetes by entering the pancreatic beta cell generating excessive nitric oxide which reacts with oxygen creating a toxin p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca4568bd4ecabda9d2def0e450a1c2f
https://doi.org/10.5402/2011/461928
https://doi.org/10.5402/2011/461928
Publikováno v:
Clinical Autonomic Research. 21:19-28
The biochemical mechanisms by which hyperglycemia causes microvascular disease and neuropathy are poorly understood. Experimental studies have established that oxidative stress is present in diabetic rodents with neuropathy, and that antioxidant ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7422aeef38858910b85de5f4b0be0e1f
https://doi.org/10.1007/s10286-010-0084-4
https://doi.org/10.1007/s10286-010-0084-4
Autor:
Robert D. Hoeldtke
Publikováno v:
Clinical Autonomic Research. 13:406-421
Although hyperglycemia has been shown to cause peripheral nerve dysfunction in patients with diabetes, the biochemical mechanisms for this effect are poorly understood. The excessive production of reactive oxygen species and reactive nitrogen species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::048b023562621a5617ff44f19824c5bd
https://doi.org/10.1007/s10286-003-0139-x
https://doi.org/10.1007/s10286-003-0139-x
Autor:
Sarah S. Warehime, Gerald R. Hobbs, Robert D. Hoeldtke, Daniel R. McNeill, Kimberly D. Bryner, Knox Van Dyke
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 88:1624-1628
The purpose of this study was to analyze biochemical measures of oxidative stress and assess their relationship to insulin requirements early in type 1 diabetes. Thirty-seven patients enrolled in a 3-yr longitudinal study of the effects of oxidative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b170c84b3722463eae4103bcc8b3ce3
https://doi.org/10.1210/jc.2002-021525
https://doi.org/10.1210/jc.2002-021525
Autor:
Sarah S. Warehime, Gary Ganser, I. Christie, Knox Van Dyke, Robert D. Hoeldtke, Jack E. Riggs, Daniel R. McNeill, Kimberly D. Bryner, Gerald R. Hobbs
Publikováno v:
Diabetes. 51:2817-2825
The present study was performed to determine whether nitric oxide overproduction is associated with deterioration in peripheral nerve function in type 1 diabetes. We measured peripheral nerve function and biochemical indicators of nitrosative stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae3bf9c0b55ad95a9f1b2cbb0226315
https://doi.org/10.2337/diabetes.51.9.2817
https://doi.org/10.2337/diabetes.51.9.2817
Redistribution of Sudomotor Responses Is an Early Sign of Sympathetic Dysfunction in Type 1 Diabetes
Autor:
Robert D. Hoeldtke, Lance F. Broy, Robert W. Phares, Kimberly D. Bryner, Gabriella G. Horvath, Gerald R. Hobbs
Publikováno v:
Diabetes. 50:436-443
Patients with diabetic neuropathy typically have decreased sweating in the feet but excessive sweating in the upper body. Previous studies of sudomotor function in diabetes have included patients with long-standing disease. The present study was desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b5c32fb485ebdfc075acaa20fdd7f8
https://doi.org/10.2337/diabetes.50.2.436
https://doi.org/10.2337/diabetes.50.2.436
Autor:
Robert D. Hoeldtke, Padma Komanduri, Gary Ganser, Kimberly D. Bryner, I. Christie, Gerald R. Hobbs
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 85:585-589
It is well documented that diabetic patients with chronic complications have decreased renin secretion and elevations in the renin precursor prorenin. It is uncertain, however, whether the abnormal processing of prorenin is reflective of microvascula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6f2923a0fddb97ea093d82629286e78
https://doi.org/10.1210/jcem.85.2.6362
https://doi.org/10.1210/jcem.85.2.6362
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 83:339-343
The purpose of this study was to compare two treatments for orthostatic hypotension, midodrine (an alpha adrenergic agonist), and octreotide (an SRIH analogue) to each other and to combination therapy. Sixteen patients participated. Our hypothesis wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94f2ed779c2bb1cc0f950af96d2dc566
https://doi.org/10.1210/jcem.83.2.4534
https://doi.org/10.1210/jcem.83.2.4534
Autor:
Santica M. Marcovina, Michele R. Byerly, Robert D. Hoeldtke, Åke Lernmark, Gabriella G. Horvath, Gerald R. Hobbs, Kimberly D. Bryner
Publikováno v:
Diabetes Care. 20:1900-1903
OBJECTIVE To analyze the effect of antibodies to glutamic acid decarboxylase (GAD65Ab) and islet cells (ICA512Ab) on glycemic control early in IDDM. RESEARCH DESIGN AND METHODS GAD65Ab and ICA512Ab were measured twice in 35 patients (10 male, 25 fema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a20e30f39279ef3298019df25d5085
https://doi.org/10.2337/diacare.20.12.1900
https://doi.org/10.2337/diacare.20.12.1900
Publikováno v:
New England Journal of Medicine. 329:611-615
Patients with orthostatic hypotension caused by autonomic neuropathy frequently have a decreased red-cell mass. This would be expected to compromise their effective circulating blood volume and aggravate the orthostatic hypotension. We studied the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca8f06191187c821c475891bcc35303
https://doi.org/10.1056/nejm199308263290904
https://doi.org/10.1056/nejm199308263290904