Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Robert D. Gerard"'
Autor:
Diana Jung, Takeshi Inagaki, Robert D. Gerard, Paul A. Dawson, Steven A. Kliewer, David J. Mangelsdorf, Antonio Moschetta
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 12, Pp 2693-2700 (2007)
Bile acid malabsorption, which in patients leads to excessive fecal bile acid excretion and diarrhea, is characterized by a vicious cycle in which the feedback regulation of bile acid synthesis is interrupted, resulting in additional bile acid produc
Externí odkaz:
https://doaj.org/article/979eed48c8cf4c658b1cfe5f58d25c8d
Supplementary Figure 3. liver picture, genotyping and sequencing data for β-catenin TALENs plus DEN induced liver tumor in C3H mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28058bad2e74894383653024a22127af
https://doi.org/10.1158/0008-5472.22404512
https://doi.org/10.1158/0008-5472.22404512
Autor:
Wan Ru Lee, Anastasia Sacharidou, Erica Behling-Kelly, Sarah C Oltmann, Weifei Zhu, Mohamed Ahmed, Robert D Gerard, David Y Hui, Jun-ichi Abe, Philip W Shaul, Chieko Mineo
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124494 (2015)
Scavenger receptor class B, type I (SR-BI) and its adaptor protein PDZK1 mediate responses to HDL cholesterol in endothelium. Whether the receptor-adaptor protein tandem serves functions in other vascular cell types is unknown. The current work deter
Externí odkaz:
https://doaj.org/article/e2b973d5016a45f9a94ab230058b7b74
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0116515 (2015)
Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine acetyltransferase, Creb binding protein (CBP), and a specific deacetylase, Sirtuin 1 (SIRT1).
Externí odkaz:
https://doaj.org/article/1c1fa0e2ee814680b2ac700a7de6140d
Autor:
Raffi Bekeredjian, Chad B Walton, Keith A MacCannell, Jennifer Ecker, Fred Kruse, Joel T Outten, David Sutcliffe, Robert D Gerard, Richard K Bruick, Ralph V Shohet
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11693 (2010)
The response to hypoxia in tissues is regulated by the heterodimeric transcription factor Hypoxia Inducible Factor-1 (HIF-1).We have created a strain of mice with inducible cardiomyocyte-specific expression of a mutated, oxygen-stable, form of HIF-1a
Externí odkaz:
https://doaj.org/article/ddb8e55358564cacb40386e4a6b5b22b
Autor:
Holly Walters, Rui Chen, Young Ah Moon, Min Xu, Jason S. Nagati, Jiwen Li, Robert D. Gerard, Sarah A. Comerford, Joseph A. Garcia, Jian Xie, Jay D. Horton, Robert E. Hammer, Chou Long Huang
Publikováno v:
Nature medicine
The hormone erythropoietin (EPO), which is synthesized in the kidney or liver of adult mammals, controls erythrocyte production and is regulated by the stress-responsive transcription factor hypoxia-inducible factor-2 (HIF-2). We previously reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0264a01859d88b47076c6712ce6593bf
https://doi.org/10.1038/nm.3587
https://doi.org/10.1038/nm.3587
Autor:
Keiji Tanigaki, Wan Ru Lee, Philip W. Shaul, Robert D. Gerard, Ryan E. Temel, Etienne Morel, Janet K. Sawyer, Manya Warrier, J. Mark Brown, Ivan S. Yuhanna, Margery A. Connelly, Chieko Mineo, Sajesh Parathath, Véronique Carrière, Sonika Saddar
Publikováno v:
Circulation Research. 112:140-151
Rationale: Signal initiation by the high-density lipoprotein (HDL) receptor scavenger receptor class B, type I (SR-BI), which is important to actions of HDL on endothelium and other processes, requires cholesterol efflux and the C-terminal transmembr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35ddd3ad5d98f897938a7129b8ee431
https://doi.org/10.1161/circresaha.112.280081
https://doi.org/10.1161/circresaha.112.280081
Publikováno v:
Molecular Endocrinology. 26:1857-1867
Progesterone (P(4)) and estradiol-17β (E(2)) play critical and opposing roles in regulating myometrial quiescence and contractility during pregnancy and labor. Although these contrasting hormonal effects are likely mediated via differential regulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aefe238dc24c7a603cfe8b479be75c9
https://doi.org/10.1210/me.2012-1199
https://doi.org/10.1210/me.2012-1199
Publikováno v:
Cancer gene therapy
Adenovirus serotype 5 remains one of the most promising vectors for delivering genetic material to cancer cells for imaging or therapy, but optimization of these agents to selectively promote tumor cell infection is needed to further their clinical d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4743f0f15ac4433fdf7125c3b6d303e
http://europepmc.org/articles/PMC3380173
http://europepmc.org/articles/PMC3380173
Autor:
Robert D. Gerard, Nora E. Renthal, Jennifer C. Condon, Koriand'r C. Williams, Carole R. Mendelson
Publikováno v:
Proceedings of the National Academy of Sciences. 109:7529-7534
During pregnancy, uterine quiescence is maintained by increased progesterone receptor (PR) activity, but labor is facilitated by a series of events that impair PR function. Previously, we discovered that miR-200 family members serve as progesterone (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca5e6bab605875345d35c2c6d7e0989
https://doi.org/10.1073/pnas.1200650109
https://doi.org/10.1073/pnas.1200650109