Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Robert D. Dick"'
Autor:
Mohamed K. Khan, Meredith W. Miller, Jeremy Taylor, Navkiranjit K. Gill, Robert D. Dick, Kenneth Van Goled, George J. Brewert, Sofia D. Merajver
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 4, Iss 2, Pp 164-170 (2002)
Tetrathiomolybdate (TM) is a potent nontoxic orally delivered copper complexing agent under development for the last several years for the treatment of Wilson's disease. It has been shown to block angiogenesis in primary and metastatic tumors. Theref
Externí odkaz:
https://doaj.org/article/bbaa1a5cde434259a7fc41c3b9f31321
Autor:
Meredith Miller, Mohamed K. Khan, Jeremy M. G. Taylor, Robert D. Dick, George J. Brewert, Navkiranjit K. Gill, Sofia D. Merajver, Kenneth Van Goled
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 4, Iss 2, Pp 164-170 (2002)
Tetrathiomolybdate (TM) is a potent nontoxic orally delivered copper complexing agent under development for the last several years for the treatment of Wilson's disease. It has been shown to block angiogenesis in primary and metastatic tumors. Theref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdb9ce729cf8c7e766b4a0056d7570d
https://doi.org/10.1038/sj.neo.7900218
https://doi.org/10.1038/sj.neo.7900218
Autor:
George J. Brewer, Robert D. Dick, Sofia D. Merajver, Marty Barrios, Theodoros N. Teknos, Claudell Cox
Publikováno v:
The Laryngoscope. 111:696-701
Objective To determine whether tetrathiomolybdate (TM), a powerful chelator of copper, is capable of lowering the body stores of copper and suppressing the growth of head and neck squamous cell carcinoma in an orthotopic murine model. Study Design In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d522f63b35bf9db8e32503449b5bd9c3
https://doi.org/10.1097/00005537-200104000-00024
https://doi.org/10.1097/00005537-200104000-00024
Autor:
James A. Brunberg, Virginia Johnson, John K. Fink, George J. Brewer, Robert D. Dick, Karen J. Kluin
Publikováno v:
Journal of Laboratory and Clinical Medicine. 132:264-278
Wilson's disease is an inherited disease of copper accumulation caused by a failure of biliary excretion of excess copper. Accumulated copper causes liver disease in these patients, and in perhaps two thirds of patients, it causes brain damage leadin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca7ebe686a4b790335057900a970ad2f
https://doi.org/10.1016/s0022-2143(98)90039-7
https://doi.org/10.1016/s0022-2143(98)90039-7
Publikováno v:
The American Journal of the Medical Sciences. 305:199-202
A considerable body of data is now available indicating the efficacy and lack of toxicity of zinc treatment of Wilson's disease. Dose-response studies have shown that regimens of 50 mg of elemental zinc 3 times a day (50 mg x 3), 25 mg x 3, and 50 mg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7856078262e28fae7bc350145cdc7426
https://doi.org/10.1097/00000441-199304000-00001
https://doi.org/10.1097/00000441-199304000-00001
Autor:
Roberta M. Tankanow, Vilma Yuzbasiyan-Gurkin, George J. Brewer, Robert D. Dick, Anne B. Young, Karen J. Kluin
Publikováno v:
Archives of Neurology. 48:42-47
Patients with Wilson's disease who present with acute neurological symptoms often become clinically worse when initially treated with penicillamine. Other available anticopper drug therapies do not appear to offer a solution to this treatment problem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9afc742a709b2e21339f3caee43e855a
https://doi.org/10.1001/archneur.1991.00530130050019
https://doi.org/10.1001/archneur.1991.00530130050019
Publikováno v:
Investigative ophthalmologyvisual science. 46(1)
To determine the effects of tetrathiomolybdate (TM), a copper-chelating agent, on retinal angiogenesis and vascular endothelial growth factor (VEGF) in a mouse model of retinal neovascularization.Postnatal day (P)7 C57BL/6N mice were exposed to 75% +
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de43425ee391718bf215e55f741dc732
https://pubmed.ncbi.nlm.nih.gov/15623788
https://pubmed.ncbi.nlm.nih.gov/15623788
Autor:
Cisca Wijmenga, Colin S. Duckett, George J. Brewer, Lakshmanan Ganesh, Ezra Burstein, Robert D. Dick, Gary J. Nabel, Leo W. J. Klomp, Bart van de Sluis, John C. Wilkinson
Publikováno v:
The EMBO Journal, 23(1), 244-254. Wiley
XIAP is a potent suppressor of apoptosis that directly inhibits specific members of the caspase family of cysteine proteases. Here we demonstrate a novel role for XIAP in the control of intracellular copper levels. XIAP was found to interact with MUR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a0858129ffccc7ad0b46a165d9e7e3
https://research.rug.nl/en/publications/91a71ab5-bd90-494a-adf7-d3bc926f74b9
https://research.rug.nl/en/publications/91a71ab5-bd90-494a-adf7-d3bc926f74b9
Publikováno v:
The Journal of laboratory and clinical medicine. 142(6)
We have treated 9 patients who presented with hepatic decompensation resulting from Wilson's disease with a combination of trientine and zinc, generally for at least 4 months, followed by transition to zinc maintenance therapy. All of these patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6df623d9f0b5c88c76134b641a7c461
https://pubmed.ncbi.nlm.nih.gov/14713890
https://pubmed.ncbi.nlm.nih.gov/14713890
Autor:
Robert D. Dick, George J. Brewer, Claudell Cox, Sofia D. Merajver, J. Lee, Theodoros N. Teknos, Sirius Yoo
Publikováno v:
Archives of otolaryngology--headneck surgery. 129(7)
Objective: To determine whether long-term therapy with tetrathiomolybdate suppresses tumor growth in an animal model. Design: In vivo murine model. Subjects: Thirteen 8-week-old C3H/HeJ mice, randomly assigned to a tetrathiomolybdate treatment group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d3257e071ce54ea9f74d13a3bdeb79
https://pubmed.ncbi.nlm.nih.gov/12874082
https://pubmed.ncbi.nlm.nih.gov/12874082