Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Robert D. C. Saunders"'
Interstrand crosslinks (ICLs) present a major threat to genome integrity, preventing both the correct transcription of active chromatin and complete replication of the genome. This is exploited in genotoxic chemotherapy where ICL induction is used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7636da03b87d944aa1e8a1cd6dbfda2
https://doi.org/10.1101/284307
https://doi.org/10.1101/284307
Autor:
Stephen Gilmore, Chris P. Barnes, Geraint M.H. Thomas, Philip Lewis, David R. Morse, David Crowe, Clare Sansom, Adrian J. Shepherd, Gerold Baier, Robert D. C. Saunders, Uwe Grimm
‘Big Data’ and a surge in quantitative methodologies increasingly urge bioresearchers to train and improve their mathematical and computational skills. In response to this challenge the Biotechnology and Biological Sciences Research Council in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba40f95540c3c6542aea3fc609044922
Autor:
Penelope A. Mason, Robert D. C. Saunders, Ralph Lasala, Tim Robbins, Ivan Boubriak, Lynne S. Cox
Publikováno v:
Age
Werner syndrome (WS) is a rare late-onset premature ageing disease showing many of the phenotypes associated with normal ageing, and provides one of the best models for investigating cellular pathways that lead to normal ageing. WS is caused by mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb3117d581e251ce1f2dc104f15963e
https://doi.org/10.1007/s11357-012-9411-0
https://doi.org/10.1007/s11357-012-9411-0
Human progeroid Werner syndrome provides the current best model for analysis of human aging, recapitulating many aspects of normal aging as a result of mutation of the WRN gene. This gene encodes a RecQ-type helicase with additional exonuclease activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6c6e8930182ff835c03d3d2e24b32c
https://ora.ox.ac.uk/objects/uuid:6f893359-802a-45d7-a37d-a6c580fa94ad
https://ora.ox.ac.uk/objects/uuid:6f893359-802a-45d7-a37d-a6c580fa94ad
Autor:
Penelope A. Mason, Robert D. C. Saunders, Joel Dockray, Ivan Boubriak, David J. Clancy, Lynne S. Cox
Publikováno v:
Biogerontology. 10:267-277
The premature human ageing Werner's syndrome is caused by loss or mutation of the WRN helicase/exonuclease. We have recently identified the orthologue of the WRN exonuclease in flies, DmWRNexo, encoded by the CG7670 locus, and showed very high levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528f5444eb7469273e98c8fe8e46ab10
https://doi.org/10.1007/s10522-008-9181-3
https://doi.org/10.1007/s10522-008-9181-3
Publikováno v:
Aging Cell
The premature human aging Werner syndrome (WS) is caused by mutation of the RecQ-family WRN helicase, which is unique in possessing also 3?�5? exonuclease activity. WS patients show significant genomic instability with elevated cancer incidence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2782648bdd361197672fee42b062ac4
http://europepmc.org/articles/PMC2408639
http://europepmc.org/articles/PMC2408639
Autor:
Andreas Vilcinskas, Robert D. C. Saunders, Eduardo Thüroff, Ernst-W Knapp, Andres Jarrin, Marianne Wedde, Horst Kress, Chris Weise, Marcel Schmidt am Busch
Publikováno v:
Insect Biochemistry and Molecular Biology. 34:855-869
From the Drosophila virilis late puff region 31C, we microcloned two neighbouring genes, Kil-1 and Kil-2, that encode putative Kunitz serine protease inhibitor like proteins. The Kil-1 gene is expressed exclusively in prepupal salivary glands. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0eeeae42defd5738b6aed3c934a7eef
https://doi.org/10.1016/j.ibmb.2004.05.006
https://doi.org/10.1016/j.ibmb.2004.05.006
Autor:
John D. Hayes, Robert D. C. Saunders, Michael McMahon, Joanne Mathers, Jennifer Fraser, Lesley I. McLellan
Publikováno v:
Biochemical Society Symposia. 71:157-176
Aerobic cells produce reactive oxygen species as a consequence of normal cellular metabolism, and an array of antioxidant systems are in place to maintain the redox balance. When the redox equilibrium of the cell is upset by pro-oxidant environmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458cee8bf3a8d60cf2eeaf7720654178
https://doi.org/10.1042/bss0710157
https://doi.org/10.1042/bss0710157
Publikováno v:
European Journal of Biochemistry. 271:1054-1062
Ouabain, a sodium pump (Na+/ K+-ATPase) inhibitor, has been shown to act as a hormone and is possibly involved in the pathogenesis of hypertension. The mechanism by which ouabain may act was investigated using primary cultures of human umbilical arte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f4a098e0f34a42c69914b0ee7100b28
https://doi.org/10.1111/j.1432-1033.2004.04012.x
https://doi.org/10.1111/j.1432-1033.2004.04012.x
Autor:
Concepcion Ferraz, Phillipe Valenti, Hugo J. Bellen, Nicole Beinert, Valerie Lelaure, Beatriz de Pablos, Dana Borkova, Cathy Salles, Nadine S. Henderson, Christine Brun, Francis Galibert, David Harris, Edouard Cadieu, Wilfried Janning, Péter Deák, Paul J. McMillan, Panayiotis V. Benos, Robert D. C. Saunders, Foteini Mourkioti, Slava Bolshakov, Encarnación Madueño, Annette Peter, Alain Bucheton, George Papagiannakis, Sophie Vidal, Stéphanie Gloux, Lee Murphy, Belén Miñana, Gordon Dowe, Alain Billaud, Ulrich Schäfer, Debbie Callister, Lefteris Spanos, Yuchun He, David M. Glover, Evelyn Tait, Melanie K. Gatt, Lior Pachter, Herbert Jäckle, Lorna Campbell, Lore Dentzer, Meike Werner, Jacques Demaille, Inga Siden-Kiamos, Juan Modolell, Michael Ashburner, Robert Klapper, Fotis C. Kafatos, Christos Louis, Stéphanie Mottier, Peter Burkert, Petra Schöttler, Stéphane Dréano, Bart Barrell
Publikováno v:
EMBO reports. 3:34-38
The Drosophila melanogaster genome consists of four chromosomes that contain 165 Mb of DNA, 120 Mb of which are euchromatic. The two Drosophila Genome Projects, in collaboration with Celera Genomics Systems, have sequenced the genome, complementing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea96198fa4cfcc7ae328cf3de959c22b
https://doi.org/10.1093/embo-reports/kvf012
https://doi.org/10.1093/embo-reports/kvf012