Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Robert D. Boyer"'
Autor:
David E. Timm, Leonard N. Boggs, Brian Michael Mathes, Yuan Shi, Mario Barberis, Zhixiang Yang, Dustin J. Mergott, Scott A. Monk, Pablo Garcia-Losada, Jose Miguel Minguez, Leonard L. Winneroski, Jon A. Erickson, Richard A. Brier, Anthony R. Borders, Stephanie L. Stout, Porter Warren J, Zoran Rankovic, Jose Eduardo Lopez, Erik James Hembre, James E. Audia, Jorg Hendle, James P. Beck, Steven James Green, Brian Morgan Watson, Patrick C. May, Robert D. Boyer
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115194
Inhibition of BACE1 has become an important strategy in the quest for disease modifying agents to slow the progression of Alzheimer's disease. We previously reported the fragment-based discovery of LY2811376, the first BACE1 inhibitor reported to dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686975880a947f8f81325a11d876e66b
https://doi.org/10.1016/j.bmc.2019.115194
https://doi.org/10.1016/j.bmc.2019.115194
Publikováno v:
Tetrahedron Letters. 55:5529-5532
Novel 3,4-dihydropyridones were efficiently prepared via a tandem olefin isomerization–ring-closing metathesis reaction catalyzed by the second-generation Grubbs catalyst. The products were further functionalized at the 5-position, providing an int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::839b6c8618d65fda60df80f53fdb310c
https://doi.org/10.1016/j.tetlet.2014.08.025
https://doi.org/10.1016/j.tetlet.2014.08.025
Autor:
Robert D. Boyer, Richard L. Bryan
Publikováno v:
The Journal of Physical Chemistry B. 116:3772-3779
The free energy of solvation can play an important or even dominant role in the accurate prediction of binding affinities and various other molecular-scale interaction phenomena critical to the study of biochemical processes. Many research applicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0192101a47510aedee28ce50b59b73
https://doi.org/10.1021/jp300440d
https://doi.org/10.1021/jp300440d
Autor:
Frantz Victor, Deyi Zhang, Adam M. Azman, Mccarthy James R, Gregory A. Stephenson, Robert D. Boyer, David M. Bender, Jeffrey A. Peterson
Publikováno v:
Tetrahedron Letters. 49:2052-2055
Under near neutral and mildly basic conditions, primary N4-(α-aminoacyl)cytidines (4a–g) undergo a facile rearrangement to form N-(4-cytidinyl)amino acid amides (5a–g). Secondary aminoacyl derivatives rearrange with other competing pathways. Ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ca301120bfcbaa4eee1a5605d1dc5ab
https://doi.org/10.1016/j.tetlet.2008.02.015
https://doi.org/10.1016/j.tetlet.2008.02.015
Autor:
John E. Toth, Matthew Ernst Voss, Robert D. Boyer, Hong-Yu Li, Sreenivasa R. Mundla, Yan Wang, Arindam Chatterjee, J. Scott Sawyer, William Thomas Mcmillen
Publikováno v:
Tetrahedron. 63:11763-11770
A simple and efficient synthesis of dihydropyrrolopyrazole boronic acid intermediate ( 5 ) has been developed. Utilization of a three-component Suzuki–Miyaura/etherification with microwave heating led to advanced compound 11 in high yield and with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73e4da3cb52fd9695a0f3e1a1493c3a2
https://doi.org/10.1016/j.tet.2007.08.069
https://doi.org/10.1016/j.tet.2007.08.069
Publikováno v:
ChemInform. 46
The conversion of N-allyl amides into dihydropyridines proceeds with high regio- and chemoselectivity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65260e6f7fb85b37b30b9b78eff970af
https://doi.org/10.1002/chin.201511206
https://doi.org/10.1002/chin.201511206
Autor:
Stephanie L. Stout, Patrick C. May, Brian Morgan Watson, Pablo Garcia Losada, Valentine J. Klimkowski, Brian Michael Mathes, David E. Timm, Dustin J. Mergott, Scott A. Monk, Leonard L. Winneroski, Leonard N. Boggs, James P. Beck, James E. Audia, Matthew Allen Schiffler, Richard A. Brier, Anthony R. Borders, Jon A. Erickson, Robert D. Boyer, Kevin John Hudziak
Publikováno v:
Bioorganicmedicinal chemistry. 23(13)
The BACE1 enzyme is a key target for Alzheimer’s disease. During our BACE1 research efforts, fragment screening revealed that bicyclic thiazine 3 had low millimolar activity against BACE1. Analysis of the co-crystal structure of 3 suggested that po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01477228c3c9d6ec449c18a60008a90e
https://pubmed.ncbi.nlm.nih.gov/26001341
https://pubmed.ncbi.nlm.nih.gov/26001341
Publikováno v:
Tetrahedron Letters. 54:6005-6007
Intramolecular click chemistry was utilized to effect synthesis of the benzofused, triazole ring systems. The trimethylsilyl group was found to impede the reaction progress, and therefore, conditions employing in situ removal of the TMS group coupled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::266d479980af0e85dc09016b8d4821f4
https://doi.org/10.1016/j.tetlet.2013.08.065
https://doi.org/10.1016/j.tetlet.2013.08.065
Publikováno v:
Modelling and Simulation in Materials Science and Engineering. 12:1017-1029
Multiplane shear deformation behaviour in face-centred cubic metals, aluminium and copper, is studied and empirical many-body potential results are directly compared with ab initio electronic structure calculations. An analysis of stress–displaceme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6b19aca6920d5e408ecb8c904674283
https://doi.org/10.1088/0965-0393/12/5/017
https://doi.org/10.1088/0965-0393/12/5/017
Publikováno v:
Magnetic Resonance in Chemistry. 42:301-307
Compensation of refocusing inefficiency in a gHMBC experiment by replacing the rectangular pi pulse with a pair of adiabatic pulses with synchronized inversion sweep (CRISIS) significantly improves the performance of the gHMBC experiment. The CRISIS-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d132cb7e28e506dc26e63e1fa2703d
https://doi.org/10.1002/mrc.1316
https://doi.org/10.1002/mrc.1316