Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Robert D. Bell"'
Autor:
Magdalena Kurtyka, Frank Wessely, Sarah Bau, Eseoghene Ifie, Liqun He, Nienke M. de Wit, Alberte Bay Villekjær Pedersen, Maximilian Keller, Caleb Webber, Helga E. de Vries, Olaf Ansorge, Christer Betsholtz, Marijke De Bock, Catarina Chaves, Birger Brodin, Morten S. Nielsen, Winfried Neuhaus, Robert D. Bell, Tamás Letoha, Axel H. Meyer, Germán Leparc, Martin Lenter, Dominique Lesuisse, Zameel M. Cader, Stephen T. Buckley, Irena Loryan, Claus U. Pietrzik
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151406- (2024)
Despite extensive research, targeted delivery of substances to the brain still poses a great challenge due to the selectivity of the blood-brain barrier (BBB). Most molecules require either carrier- or receptor-mediated transport systems to reach the
Externí odkaz:
https://doaj.org/article/24cf1f3bfe6c41b79a62e5eaa26fce38
Autor:
Abhay P. Sagare, Robert D. Bell, Zhen Zhao, Qingyi Ma, Ethan A. Winkler, Anita Ramanathan, Berislav V. Zlokovic
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/7d3b633a698a42848e3c3cf0dfb22d15
Autor:
Abhay P. Sagare, Robert D. Bell, Zhen Zhao, Qingyi Ma, Ethan A. Winkler, Anita Ramanathan, Berislav V. Zlokovic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/cd3b77f732df4e98b7513eb8b9202ec9
Autor:
Wei Chou Tseng, Veronica Reinhart, Thomas A. Lanz, Mark L. Weber, Jincheng Pang, Kevin Xuong Vinh Le, Robert D. Bell, Patricio O’Donnell, Derek L. Buhl
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Schizophrenia is a complex and heterogenous disease that presents with abnormalities in glutamate signaling and altered immune and inflammatory signals. Genome-wide association studies have indicated specific genes and pathways that may cont
Externí odkaz:
https://doaj.org/article/78b4111fc55c48a39108af05d438929d
Autor:
Georgette L. Suidan, Pradeep K. Singh, Sunita Patel-Hett, Zu-Lin Chen, Dmitri Volfson, Hitomi Yamamoto-Imoto, Erin H. Norris, Robert D. Bell, Sidney Strickland
Publikováno v:
Blood Advances, Vol 2, Iss 9, Pp 954-963 (2018)
Abstract: Alzheimer disease (AD) is a neurodegenerative disorder characterized by extracellular β-amyloid (Aβ) deposition. Although peripheral inflammation and cerebrovascular pathology are reported in AD, there is a lack of plasma biomarkers in th
Externí odkaz:
https://doaj.org/article/0e4f33cbf5d94a24b3f2a05f21603c2b
Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury
Autor:
Justin R. Piro, Georgette L. Suidan, Jie Quan, YeQing Pi, Sharon M. O’Neill, Marissa Ilardi, Nikolay Pozdnyakov, Thomas A. Lanz, Hualin Xi, Robert D. Bell, Tarek A. Samad
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-15 (2018)
Abstract Background Acute neurological insults caused by infection, systemic inflammation, ischemia, or traumatic injury are often associated with breakdown of the blood-brain barrier (BBB) followed by infiltration of peripheral immune cells, cytotox
Externí odkaz:
https://doaj.org/article/0481b9a2d34f41619984e7c612e1c01e
Autor:
Abhay P. Sagare, Robert D. Bell, Zhen Zhao, Qingyi Ma, Ethan A. Winkler, Anita Ramanathan, Berislav V. Zlokovic
Publikováno v:
Nature Communications, Vol 4, Iss 1, Pp 1-14 (2013)
Abstract Pericytes are cells in the blood–brain barrier that degenerate in Alzheimer’s disease (AD), a neurological disorder associated with neurovascular dysfunction, abnormal elevation of amyloid β-peptide (Aβ), tau pathology and neuronal los
Externí odkaz:
https://doaj.org/article/9b683a1b3a074ced80d92525f5f00e8e
Autor:
Megan L. Brophy, John C. Stansfield, Youngwook Ahn, Seng H. Cheng, John E. Murphy, Robert D. Bell
Publikováno v:
Journal of Inherited Metabolic Disease. 45:481-492
Classic galactosemia (CG) is a rare disorder of autosomal recessive inheritance. It is caused predominantly by point mutations as well as deletions in the gene encoding the enzyme galactose-1-phosphate uridyltransferase (GALT). The majority of the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae494f19470e921a5c2cec5beb18d5f5
https://doi.org/10.1002/jimd.12468
https://doi.org/10.1002/jimd.12468
Publikováno v:
Nature Reviews Drug Discovery. 20:362-383
Achieving sufficient delivery across the blood–brain barrier is a key challenge in the development of drugs to treat central nervous system (CNS) disorders. This is particularly the case for biopharmaceuticals such as monoclonal antibodies and enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c109d04778ae14c96eabf8b352c0828
https://doi.org/10.1038/s41573-021-00139-y
https://doi.org/10.1038/s41573-021-00139-y
Autor:
Robert D. Bell, Ethan A. Winkler, Itender Singh, Abhay P. Sagare, Rashid Deane, Zhenhua Wu, David M. Holtzman, Christer Betsholtz, Annika Armulik, Jan Sallstrom, Bradford C. Berk, Berislav V. Zlokovic
Publikováno v:
Nature. 617:E12-E12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08fe99915f0abfd8a23e6dd53a87be2c
https://doi.org/10.1038/s41586-023-06118-0
https://doi.org/10.1038/s41586-023-06118-0