Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Robert D Kuchta"'
Autor:
Dana Ungermannova, Seth J Parker, Christopher G Nasveschuk, Wei Wang, Bettina Quade, Gan Zhang, Robert D Kuchta, Andrew J Phillips, Xuedong Liu
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29208 (2012)
Protein ubiquitination plays an important role in the regulation of almost every aspect of eukaryotic cellular function; therefore, its destabilization is often observed in most human diseases and cancers. Consequently, developing inhibitors of the u
Externí odkaz:
https://doaj.org/article/2a8a5c698f3449d8a82141713b9f224b
Autor:
Michał Ochal, Rafał Skutecki, Małgorzata Romaszko, Kornelia Tokarczyk-Malesa, Robert D. Kuchta
Publikováno v:
Polish Annals of Medicine.
Introduction: Viruses, such as SARS-CoV-2, are airborne and transmitted mainly via droplets. This type of transmission is particularly significant for people remaining in common closed space. It is also crucial in the case of homeless people who rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd03dbae2d8a7035d14afd30b2af38ee
https://doi.org/10.29089/2021.21.00180
https://doi.org/10.29089/2021.21.00180
Publikováno v:
Biochemistry. 56:2651-2662
The herpes helicase-primase (UL5-UL8-UL52) very inefficiently unwinds double stranded DNA. To better understand the mechanistic consequences of this inefficiency, we investigated protein displacement activity by UL5-UL8-UL52, as well as the impact of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadd0f8e951b7023663f92cdbf9efc6e
https://doi.org/10.1021/acs.biochem.6b01128
https://doi.org/10.1021/acs.biochem.6b01128
Autor:
Marvin H. Caruthers, Dylan W. Domaille, Glenn R. Hafenstine, Ryan McCaffrey, Sarah Michelle Dickerson, Wei Zhang, Jennifer N. Cha, Chao Yu, Kenji D. Okochi, Luca Monfregola, Yinghua Jin, Robert D. Kuchta
Publikováno v:
The Journal of Organic Chemistry. 82:10803-10811
Small molecule/DNA hybrids (SMDHs) have been considered as nanoscale building blocks for engineering 2D and 3D supramolecular DNA assembly. Herein, we report an efficient on-bead amide-coupling approach to prepare SMDHs with multiple oligodeoxynucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbcadf3f8278aaa387e60e751801d88
https://doi.org/10.1021/acs.joc.6b02942
https://doi.org/10.1021/acs.joc.6b02942
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0189938 (2017)
PLoS ONE, Vol 12, Iss 12, p e0189938 (2017)
Background The homeless constitute a subpopulation particularly exposed to atmospheric conditions, which, in the temperate climate zone, can result in both cold and heat stress leading to the increased mortality hazard. Environmental conditions have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f0a963989c6fce161027e91e272175
http://europepmc.org/articles/PMC5739436
http://europepmc.org/articles/PMC5739436
Publikováno v:
Biochemistry
The herpes polymerase–processivity factor complex consists of the catalytic UL30 subunit containing both polymerase and proofreading exonuclease activities and the UL42 subunit that acts as a processivity factor. Curiously, the highly active exonuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fb8bae746ed3f7a3a1d9af2b390476
https://doi.org/10.1021/bi500840v
https://doi.org/10.1021/bi500840v
Publikováno v:
Journal of the American Chemical Society. 135:1205-1208
To better understand the energetics of accurate DNA replication, we directly measured ΔG(o) for the incorporation of a nucleotide into elongating dsDNA in solution (ΔG(o)(incorporation)). Direct measurements of the energetic difference between synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a3a54b90a7c8d6d4e2555fa72ac6c4
https://doi.org/10.1021/ja309866m
https://doi.org/10.1021/ja309866m
Autor:
Cezary Opalach, Jerzy Romaszko, Robert D. Kuchta, Alina Borkowska, Marcin Jaracz, Adam Buciński
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0162381 (2016)
PLoS ONE, Vol 11, Iss 9, p e0162381 (2016)
BACKGROUND AND OBJECTIVES: The ways in which homeless individuals cope with stress may differ from those relied upon by the members of the general population and these differences may either be the result or the cause of their living conditions. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29790fe74009850dbb4630b5e869e6e4
http://europepmc.org/articles/PMC5012672
http://europepmc.org/articles/PMC5012672
Publikováno v:
Biochemistry. 55(7)
We examined the impact of two clinically approved anti-herpes drugs, acyclovir and Forscarnet (phosphonoformate) on the exonuclease activity of the herpes simplex virus-1 DNA polymerase, UL30. Acyclovir triphosphate and Foscarnet, along with the clos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1dae646eb97ec27ec6828fc0ab2373e
https://pubmed.ncbi.nlm.nih.gov/26836009
https://pubmed.ncbi.nlm.nih.gov/26836009
Publikováno v:
Analytical Biochemistry. 416:53-60
The cytosine analogs 1,3-diaza-2-oxophenothiazine (tC) and 1,3-diaza-2-oxophenoxazine (tCo) stand out among fluorescent bases due to their unquenched fluorescence emission in double-stranded DNA. Recently, we reported a method for the generation of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be5e4cb68604186f94844234226fb77a
https://doi.org/10.1016/j.ab.2011.04.033
https://doi.org/10.1016/j.ab.2011.04.033