Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Robert D Harvey"'
Autor:
Pei-Chi Yang, Britton W Boras, Mao-Tsuen Jeng, Steffen S Docken, Timothy J Lewis, Andrew D McCulloch, Robert D Harvey, Colleen E Clancy
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 7, p e1005005 (2016)
Subcellular compartmentation of the ubiquitous second messenger cAMP has been widely proposed as a mechanism to explain unique receptor-dependent functional responses. How exactly compartmentation is achieved, however, has remained a mystery for more
Externí odkaz:
https://doaj.org/article/773b99d8f5d04386a4cbea3f0e8ec881
Autor:
Sara D Pugh, David A MacDougall, Shailesh R Agarwal, Robert D Harvey, Karen E Porter, Sarah Calaghan
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106905 (2014)
The number of people taking statins is increasing across the globe, highlighting the importance of fully understanding statins' effects on the cardiovascular system. The beneficial impact of statins extends well beyond regression of atherosclerosis t
Externí odkaz:
https://doaj.org/article/dd91de595505428ea0da847f5f3119e5
Autor:
Shailesh R Agarwal, Pei-Chi Yang, Monica Rice, Cherie A Singer, Viacheslav O Nikolaev, Martin J Lohse, Colleen E Clancy, Robert D Harvey
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95835 (2014)
Spatially restricting cAMP production to discrete subcellular locations permits selective regulation of specific functional responses. But exactly where and how cAMP signaling is confined is not fully understood. Different receptors and adenylyl cycl
Externí odkaz:
https://doaj.org/article/8e03eb1e909b4ba8ac469ca509655384
Autor:
Colleen E. Clancy, Robert D. Harvey
Publikováno v:
J Physiol
The Journal of physiology, vol 599, iss 20
The Journal of physiology, vol 599, iss 20
The small diffusible second messenger 3',5'-cyclic adenosine monophosphate (cAMP) is found in virtually every cell in our bodies, where it mediates responses to a variety of different G protein coupled receptors (GPCRs). In the heart, cAMP plays a cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2418914e36d299cbaf757c910099a73
https://doi.org/10.1113/jp280801
https://doi.org/10.1113/jp280801
Autor:
Rinzhin Tshering Sherpa, Karni S. Moshal, Shailesh R. Agarwal, Rennolds S. Ostrom, Robert D. Harvey
Publikováno v:
Biophysical Journal. 122:15a-16a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::078724e9d4f394a323738a0d311834e6
https://doi.org/10.1016/j.bpj.2022.11.311
https://doi.org/10.1016/j.bpj.2022.11.311
Autor:
Michael W. Rudokas, Robert D. Harvey, Alejandra Sataray-Rodriguez, Karni S. Moshal, Shailesh R. Agarwal, John P. Post, Rinzhin T. Sherpa
Publikováno v:
British Journal of Pharmacology. 178:1574-1587
Background and purpose In cardiac myocytes, cyclic AMP (cAMP) produced by both β1 - and β2 -adrenoceptors increases L-type Ca2+ channel activity and myocyte contraction. However, only cAMP produced by β1 -adrenoceptors enhances myocyte relaxation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f2e982955411d92d07816d5abee083b
https://doi.org/10.1111/bph.15382
https://doi.org/10.1111/bph.15382
Autor:
Chase M. Fiore, Michael Rudokus, Rinzhin Tshering Sherpa, Karni S. Moshal, Shailesh R. Agarwal, Robert D. Harvey
Publikováno v:
Biophysical Journal. 122:512a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bdddab5cfa9b60f9a63cc963428842d
https://doi.org/10.1016/j.bpj.2022.11.2726
https://doi.org/10.1016/j.bpj.2022.11.2726
Publikováno v:
Biophysical Journal. 122:512a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c132c8cec3aefc63b52c79309c1d6385
https://doi.org/10.1016/j.bpj.2022.11.2725
https://doi.org/10.1016/j.bpj.2022.11.2725
Autor:
Adam Wadsworth, Michael W. Rudokas, Shailesh R. Agarwal, Robert D. Harvey, Rinzhin T. Sherpa, Karni S. Moshal, Chase Fiore
Publikováno v:
Physiological Reports
Physiological Reports, Vol 9, Iss 17, Pp n/a-n/a (2021)
Physiological Reports, Vol 9, Iss 17, Pp n/a-n/a (2021)
Compartmentation of cAMP signaling is a critical factor for maintaining the integrity of receptor‐specific responses in cardiac myocytes. This phenomenon relies on various factors limiting cAMP diffusion. Our previous work in adult rat ventricular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579a53c952025b6e22ceeb06096674ed
https://doi.org/10.14814/phy2.15015
https://doi.org/10.14814/phy2.15015
Publikováno v:
Cell Signal
Activation of different receptors that act by generating the common second messenger cyclic adenosine monophosphate (cAMP) can elicit distinct functional responses in cardiac myocytes. Selectively sequestering cAMP activity to discrete intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b71a55feb80c4db47f9ba5ff85bd24
https://pubmed.ncbi.nlm.nih.gov/34687901
https://pubmed.ncbi.nlm.nih.gov/34687901