Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Robert D Gray"'
Publikováno v:
BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)
Background Pulmonary exacerbations (PExs) are clinically important in people with cystic fibrosis (CF). Multiple definitions have been used for PEx, and this scoping review aimed to identify the different definitions reported in the literature and to
Externí odkaz:
https://doaj.org/article/9653956dcfff48b78201a5d9c4baf5b7
Autor:
Lynn W DeLeeuw, Robert C Monsen, Vytautas Petrauskas, Robert D Gray, Lina Baranauskiene, Daumantas Matulis, John O Trent, Jonathan B Chaires
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0245675 (2021)
The protein POT1 (Protection of Telomeres 1) is an integral part of the shelterin complex that protects the ends of human chromosomes from degradation or end fusions. It is the only component of shelterin that binds single-stranded DNA. We describe h
Externí odkaz:
https://doaj.org/article/d54a95b20059451db626866be17532dd
Autor:
Brian J McHugh, Rongling Wang, Hsin-Ni Li, Paula E Beaumont, Rebekah Kells, Holly Stevens, Lisa Young, Adriano G Rossi, Robert D Gray, Julia R Dorin, Emily L Gwyer Findlay, David Brough, Donald J Davidson
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007694 (2019)
Pulmonary infections are a major global cause of morbidity, exacerbated by an increasing threat from antibiotic-resistant pathogens. In this context, therapeutic interventions aimed at protectively modulating host responses, to enhance defence agains
Externí odkaz:
https://doaj.org/article/b0ced40c6ffd4268b60634efa7b7782e
Autor:
Santi Mestre-Fos, Petar I Penev, John Colin Richards, William L Dean, Robert D Gray, Jonathan B Chaires, Loren Dean Williams
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226177 (2019)
Mammalian and bird ribosomes are nearly twice the mass of prokaryotic ribosomes in part because of their extraordinarily long rRNA tentacles. Human rRNA tentacles are not fully observable in current three-dimensional structures and their conformation
Externí odkaz:
https://doaj.org/article/d9c87c731498483f8c555473ba91cdd0
Autor:
Maryam Zahin, William L Dean, Shin-Je Ghim, Joongho Joh, Robert D Gray, Sujita Khanal, Gregory D Bossart, Antonio A Mignucci-Giannoni, Eric C Rouchka, Alfred B Jenson, John O Trent, Jonathan B Chaires, Julia H Chariker
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195625 (2018)
The Florida manatee (Trichechus manatus latirotris) is a threatened aquatic mammal in United States coastal waters. Over the past decade, the appearance of papillomavirus-induced lesions and viral papillomatosis in manatees has been a concern for tho
Externí odkaz:
https://doaj.org/article/87735bf4c1f340e58a3c83c0df098c6e
Autor:
Jonathan B Chaires, John O Trent, Robert D Gray, William L Dean, Robert Buscaglia, Shelia D Thomas, Donald M Miller
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115580 (2014)
Mutations occur at four specific sites in the hTERT promoter in >75% of glioblastomas and melanomas, but the mechanism by which the mutations affect gene expression remains unexplained. We report biophysical computational studies that show that the h
Externí odkaz:
https://doaj.org/article/4b8ffa132fa7426e88368c69a7a664b2
Autor:
William H. Skinner, Nicola Robinson, Gareth R. Hardisty, Holly Fleming, Ailsa Geddis, Mark Bradley, Robert D. Gray, Colin J. Campbell
Publikováno v:
Skinner, W H, Robinson, N, Hardisty, G R, Fleming, H, Geddis, A, Bradley, M, Gray, R D & Campbell, C J 2023, ' SERS microsensors for pH measurements in the lumen and ECM of stem cell derived human airway organoids ', Chemical Communications . https://doi.org/10.1039/D2CC06582G
Patient derived organoids have the potential to improve the physiological relevance of in vitro disease models. However, the 3D architecture of these self-assembled cellular structures makes probing their biochemistry more complex than in traditional
Autor:
Robert D Gray, Benjamin Steinberg
Publikováno v:
Algebraic & Geometric Topology. 22:3083-3170
Autor:
Suzanne C. Carter, Alessandro N. Franciosi, Kate M. O’Shea, Orla M. O’Carroll, Ashutosh Sharma, Aoife Bell, Brian Keogan, Paul O’Reilly, Suzie Coughlan, Sheonagh M. Law, Robert D. Gray, Katherine B. Hisert, Pradeep K. Singh, Gordon Cooke, Brenda Grogan, Cillian F. De Gascun, Charles G. Gallagher, Trevor T. Nicholson, Bradley S. Quon, Edward F. McKone
Publikováno v:
Annals of the American Thoracic Society. 19:1818-1826
Autor:
Jonathan L. Gillan, Mithil Chokshi, Gareth R. Hardisty, Sara Clohisey Hendry, Daniel Prasca-Chamorro, Nicola J. Robinson, Benjamin Lasota, Richard Clark, Lee Murphy, Moira K. B. Whyte, J. Kenneth Baillie, Donald J. Davidson, Gang Bao, Robert D. Gray
Publikováno v:
Gillan, J L, Chokshi, M, Hardisty, G R, Clohisey Hendry, S, Prasca-Chamorro, D, Robinson, N J, Lasota, B, Clark, R, Murphy, L, Whyte, M K B, Baillie, J K, Davidson, D J, Bao, G & Gray, R D 2023, ' CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages ', Science Advances, vol. 9, no. 21, eadg5128, pp. 1-17 . https://doi.org/10.1126/sciadv.adg5128
An intense, nonresolving airway inflammatory response leads to destructive lung disease in cystic fibrosis (CF). Dysregulation of macrophage immune function may be a key facet governing the progression of CF lung disease, but the underlying mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1d6f49036f9327fdf6f94531d99523
https://www.pure.ed.ac.uk/ws/files/350052675/sciadv.adg5128.pdf
https://www.pure.ed.ac.uk/ws/files/350052675/sciadv.adg5128.pdf