Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Robert D Goldman"'
Autor:
Miriam S Weber, Matthias Eibauer, Suganya Sivagurunathan, Thomas M Magin, Robert D Goldman, Ohad Medalia
Publikováno v:
eLife, Vol 10 (2021)
Keratin intermediate filaments are an essential and major component of the cytoskeleton in epithelial cells. They form a stable yet dynamic filamentous network extending from the nucleus to the cell periphery, which provides resistance to mechanical
Externí odkaz:
https://doaj.org/article/f4deaa2647f04374a74ffe95884de6d6
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69169 (2013)
The nuclear lamins play important roles in the structural organization and function of the metazoan cell nucleus. Recent studies on B-type lamins identified a requirement for lamin B1 (LB1) in the regulation of cell proliferation in normal diploid ce
Externí odkaz:
https://doaj.org/article/12c0cb433f0d40f9af56806be3425d22
Autor:
Boris Grin, Saleemulla Mahammad, Tatjana Wedig, Megan M Cleland, Lester Tsai, Harald Herrmann, Robert D Goldman
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39065 (2012)
Withaferin A (WFA) is a steroidal lactone present in Withania somnifera which has been shown in vitro to bind to the intermediate filament protein, vimentin. Based upon its affinity for vimentin, it has been proposed that WFA can be used as an anti-t
Externí odkaz:
https://doaj.org/article/64c94f5285614ee9a384b130be238e2a
Autor:
Suganya Sivagurunathan, Amir Vahabikashi, Haiqian Yang, Jun Zhang, Kelly Vazquez, Dhivyaa Rajasundaram, Yuliya Politanska, Hiam Abdala-Valencia, Jacob Notbohm, Ming Guo, Stephen A. Adam, Robert D. Goldman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Vimentin is a Type III intermediate filament (VIF) cytoskeletal protein that regulates the mechanical and migratory behavior of cells. Its expression is considered to be a marker for the epithelial to mesenchymal transition (EMT) that takes place in
Externí odkaz:
https://doaj.org/article/77d566af8a374e9e9a874adf3df64d39
Autor:
Matthias Eibauer, Miriam S. Weber, Rafael Kronenberg-Tenga, Charlie T. Beales, Rajaa Boujemaa-Paterski, Yagmur Turgay, Suganya Sivagurunathan, Julia Kraxner, Sarah Köster, Robert D. Goldman, Ohad Medalia
Intermediate filaments (IFs) are integral components of the cytoskeleton. They provide cells with tissue-specific mechanical properties and are involved in numerous cellular processes. Due to their intricate architecture, a 3D structure of IFs has re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f27facfe55c9c83595e105cf213e5dd1
https://doi.org/10.1101/2023.05.22.541714
https://doi.org/10.1101/2023.05.22.541714
Publikováno v:
Nucleic acids research. 50(20)
The chromatin associated with the nuclear lamina (NL) is referred to as lamina-associated domains (LADs). Here, we present an adaptation of the tyramide-signal amplification sequencing (TSA-seq) protocol, which we call chromatin pull down-based TSA-s
Autor:
Amir Vahabikashi, Suganya Sivagurunathan, Fiona Ann Sadsad Nicdao, Yu Long Han, Chan Young Park, Mark Kittisopikul, Xianrong Wong, Joseph R. Tran, Gregg G. Gundersen, Karen L. Reddy, G. W. Gant Luxton, Ming Guo, Jeffrey J. Fredberg, Yixian Zheng, Stephen A. Adam, Robert D. Goldman
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The ability of a cell to regulate its mechanical properties is central to its function. Emerging evidence suggests that interactions between the cell nucleus and cytoskeleton influence cell mechanics through poorly understood mechanisms. Here we cond
Autor:
Stephen A. Adam, Yinan Shen, David A. Weitz, Suganya Sivagurunathan, Huayin Wu, Jennifer Hyunjong Shin, Ohad Medalia, Jeffrey J. Fredberg, Robert D. Goldman, Miriam Weber
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(10)
The cytoskeleton of eukaryotic cells is primarily composed of networks of filamentous proteins, F-actin, microtubules, and intermediate filaments. Interactions among the cytoskeletal components are important in determining cell structure and in regul
Autor:
Yohei Kono, Stephen A. Adam, Karen L. Reddy, Yixian Zheng, Ohad Medalia, Robert D. Goldman, Hiroshi Kimura, Takeshi Shimi
In mammalian cell nuclei, the nuclear lamina (NL) underlies the nuclear envelope (NE) to maintain nuclear structure. The nuclear lamins, the major structural components of the NL, are involved in the protection against NE rupture induced by mechanica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510271aaa8cae0f7088a3f68c5e54aed
https://doi.org/10.1101/2022.01.05.475028
https://doi.org/10.1101/2022.01.05.475028
Publikováno v:
Bioinformatics
Motivation Microscopy images of cytoskeletal, nucleoskeletal and other structures contain complex junctions of overlapping filaments with arbitrary geometry. Yet, state-of-the-art algorithms generally perform single orientation analysis to segment th