Zobrazeno 1 - 10
of 407
pro vyhledávání: '"Robert D Goldin"'
Autor:
Nick Powell, Mark R Thursz, Kevin J Woollard, James Larkin, Samra Turajlic, Stephen R Atkinson, Robert D Goldin, Evangelos Triantafyllou, Lucia A Possamai, Charalambos G Antoniades, Cathrin L C Gudd, Eoin Mitchell, Marie-Anne Mawhin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Checkpoint inhibitor-induced hepatitis (CPI-hepatitis) is an emerging problem with the widening use of CPIs in cancer immunotherapy. Here, we developed a mouse model to characterize the mechanism of CPI-hepatitis and to therapeutically tar
Externí odkaz:
https://doaj.org/article/ef7d49df3e824b6ba015b5adda0e950e
Autor:
Vincenzo Mazzaferro, Federica Grillo, Pierluigi Toniutto, Petros Fessas, Francesco A Mauri, Teresa Marafioti, Ayse U Akarca, Alejandro Forner, Robert D Goldin, Alba Díaz, David J. Pinato, Sam M Murray, Takahiro Kaneko, Beatriz Mínguez, Valentina Cacciato, Claudio Avellini, Rosemary J. Boyton, Daniel M. Altmann, Edoardo Casagrande, Edoardo Giannini, Sherrie Bhoori
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/a973066887174810bc7aff81b2ac8b76
Autor:
Nicholas GD Masca, Elizabeth MA Hensor, Victoria R Cornelius, Francesca M Buffa, Helen M Marriott, James M Eales, Michael P Messenger, Amy E Anderson, Chris Boot, Catey Bunce, Robert D Goldin, Jessica Harris, Rod F Hinchliffe, Hiba Junaid, Shaun Kingston, Carmen Martin-Ruiz, Christopher P Nelson, Janet Peacock, Paul T Seed, Bethany Shinkins, Karl J Staples, Jamie Toombs, Adam KA Wright, M Dawn Teare
Publikováno v:
eLife, Vol 4 (2015)
Lack of reproducibility is an ongoing problem in some areas of the biomedical sciences. Poor experimental design and a failure to engage with experienced statisticians at key stages in the design and analysis of experiments are two factors that contr
Externí odkaz:
https://doaj.org/article/a0d7e699f1c042edb9b4707dd4859347
Autor:
Yiannis N Kallis, Christopher J Scotton, Alison C Mackinnon, Robert D Goldin, Nicholas A Wright, John P Iredale, Rachel C Chambers, Stuart J Forbes
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86241 (2014)
Liver fibrosis results from the co-ordinated actions of myofibroblasts and macrophages, a proportion of which are of bone marrow origin. The functional effect of such bone marrow-derived cells on liver fibrosis is unclear. We examine whether changing
Externí odkaz:
https://doaj.org/article/788281c21e9344ad8017acd62ed6eae4
Autor:
Elliot H. Akama-Garren, Paul Miller, Thomas M. Carroll, Michael Tellier, Gopinath Sutendra, Ludovico Buti, Justyna Zaborowska, Robert D. Goldin, Elizabeth Slee, Francis G. Szele, Shona Murphy, Xin Lu
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-16 (2023)
Abstract Maintenance of immunological homeostasis between tolerance and autoimmunity is essential for the prevention of human diseases ranging from autoimmune disease to cancer. Accumulating evidence suggests that p53 can mitigate phagocytosis-induce
Externí odkaz:
https://doaj.org/article/7ddb2a87a50c4c5aa87bfd63438d5eb9
Integrated phenotyping of the anti-cancer immune response in HIV-associated hepatocellular carcinoma
Autor:
David J. Pinato, Takahiro Kaneko, Antonio D’Alessio, Alejandro Forner, Petros Fessas, Beatriz Minguez, Edoardo G. Giannini, Federica Grillo, Alba Díaz, Francesco A. Mauri, Claudia A.M. Fulgenzi, Alessia Dalla Pria, Robert D. Goldin, Giulia Pieri, Pierluigi Toniutto, Claudio Avellini, Maria Corina Plaz Torres, Ayse U. Akarca, Teresa Marafioti, Sherrie Bhoori, Jose María Miró, Mark Bower, Norbert Bräu, Vincenzo Mazzaferro
Publikováno v:
JHEP Reports, Vol 5, Iss 7, Pp 100741- (2023)
Background & Aims: HIV-seropositivity shortens survival in patients with hepatocellular carcinoma (HCC). Although risk factors for HCC including HCV infection can influence T cell phenotype, it is unknown whether HIV can influence functional characte
Externí odkaz:
https://doaj.org/article/28357346c44e48efaa343ba7b862ee46
Autor:
Nila Jambulingam, Roberta Forlano, Benjamin Preston, Benjamin H. Mullish, Greta Portone, Yama Baheer, Michael Yee, Robert D. Goldin, Mark R. Thursz, Pinelopi Manousou
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3563 (2023)
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease worldwide, with fibrosis stage being the main predictor for clinical outcomes. Here, we present the metabolic profile of NAFLD patients with regards to fibrosis prog
Externí odkaz:
https://doaj.org/article/9f46d9c05799466486a87c71bac4156a
Autor:
Parvin Begum, MBChB.(Hons), Robert D. Goldin, MD, Lucia A. Possamai, PhD, Sanjay Popat, FRCP, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 9, Pp 100213- (2021)
Sotorasib is a first-in-class small molecule that irreversibly inhibits KRAS G12C, locking it in an inactive state, inhibiting oncogenic signaling, and inducing a proinflammatory microenvironment. Here, we report the first case of life-threatening he
Externí odkaz:
https://doaj.org/article/d35246bc42e64d37a88a15bf7ca7fe13
Autor:
Alexandros Arjmand, Odysseas Tsakai, Vasileios Christou, Alexandros T. Tzallas, Markos G. Tsipouras, Roberta Forlano, Pinelopi Manousou, Robert D. Goldin, Christos Gogos, Evripidis Glavas, Nikolaos Giannakeas
Publikováno v:
Information, Vol 13, Iss 4, p 160 (2022)
Non-alcoholic fatty pancreas disease (NAFPD) is a common and at the same time not extensively examined pathological condition that is significantly associated with obesity, metabolic syndrome, and insulin resistance. These factors can lead to the dev
Externí odkaz:
https://doaj.org/article/18fef1fc4b4e45a18cde2eb84a2ac301
Autor:
Stuart McPherson, Matthew J Armstrong, Jeremy F Cobbold, Lynsey Corless, Quentin M Anstee, Richard J Aspinall, Stephen T Barclay, Paul N Brennan, Tessa M Cacciottolo, Robert D Goldin, Kate Hallsworth, Vanessa Hebditch, Kathryn Jack, Helen Jarvis, Jill Johnson, Wenhao Li, Dina Mansour, Mary McCallum, Ashis Mukhopadhya, Richard Parker, Valerie Ross, Ian A Rowe, Ankur Srivastava, Prarthana Thiagarajan, Alexandra I Thompson, Jeremy Tomlinson, Emmanuel A Tsochatzis, Andrew Yeoman, William Alazawi
Publikováno v:
The Lancet Gastroenterology & Hepatology. 7:755-769
Non-alcoholic fatty liver disease (NAFLD) is common, affecting approximately 25% of the general population. The evidence base for the investigation and management of NAFLD is large and growing, but there is currently little practical guidance to supp