Výsledky vyhledávání - "Robert D Arbeit"

Akademický článek

Serial T-SPOT.TB responses in Tanzanian adolescents: Transient, persistent and irregular conversions.

Autor: Maryam A Amour, Christiaan A Rees, Patricia J Munseri, Jamila Said, Albert K Magohe, Mecky Matee, Elizabeth A Talbot, Robert D Arbeit, Kisali Pallangyo, C Fordham von Reyn

Publikováno v: PLoS ONE, Vol 17, Iss 6, p e0268685 (2022)

BackgroundProspective studies of interferon-gamma release assays (IGRA) on healthy subjects in tuberculosis-endemic regions have not examined the long-term variability of serial assays. This issue is relevant to the interpretation of tuberculosis (TB

Externí odkaz: https://doaj.org/article/ec5b57f47c29471eb2f98340c7c19c07

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Akademický článek

CD4+ T cell cytokine responses to the DAR-901 booster vaccine in BCG-primed adults: A randomized, placebo-controlled trial.

Autor: Tereza Masonou, David A Hokey, Timothy Lahey, Alice Halliday, Luis C Berrocal-Almanza, Wendy F Wieland-Alter, Robert D Arbeit, Ajit Lalvani, C Fordham von Reyn

Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0217091 (2019)

BACKGROUND:DAR-901 is an inactivated whole cell tuberculosis booster vaccine, prepared using a new scalable, broth-grown method from the master cell bank of SRL172, a vaccine previously shown to prevent tuberculosis. This study examined whether DAR-9

Externí odkaz: https://doaj.org/article/88ddceddb42140d889ed399b458a473e

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Akademický článek

Safety and immunogenicity of an inactivated whole cell tuberculosis vaccine booster in adults primed with BCG: A randomized, controlled trial of DAR-901.

Autor: C Fordham von Reyn, Timothy Lahey, Robert D Arbeit, Bernard Landry, Leway Kailani, Lisa V Adams, Brenda C Haynes, Todd Mackenzie, Wendy Wieland-Alter, Ruth I Connor, Sue Tvaroha, David A Hokey, Ann M Ginsberg, Richard Waddell

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0175215 (2017)

Development of a tuberculosis vaccine to boost BCG is a major international health priority. SRL172, an inactivated whole cell booster derived from a non-tuberculous mycobacterium, is the only new vaccine against tuberculosis to have demonstrated eff

Externí odkaz: https://doaj.org/article/72ed7a4d28b543bb9c08543d05916f7e

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Akademický článek

Immunogenicity and Protective Efficacy of the DAR-901 Booster Vaccine in a Murine Model of Tuberculosis.

Autor: Timothy Lahey, Dominick Laddy, Krystal Hill, Jacqueline Schaeffer, Alison Hogg, James Keeble, Belinda Dagg, Mei Mei Ho, Robert D Arbeit, C Fordham von Reyn

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0168521 (2016)

BACKGROUND:The development of a novel tuberculosis vaccine is a leading global health priority. SRL172, an inactivated, whole-cell mycobacterial vaccine, was safe, immunogenic and reduced the incidence of culture-confirmed tuberculosis in a phase III

Externí odkaz: https://doaj.org/article/752dbd23edf44389a36256452cb80ba1

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Akademický článek

Campylobacteriosis in urban versus rural areas: a case-case study integrated with molecular typing to validate risk factors and to attribute sources of infection.

Autor: Simon Lévesque, Eric Fournier, Nathalie Carrier, Eric Frost, Robert D Arbeit, Sophie Michaud

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e83731 (2013)

Campylobacter infection is a leading cause of bacterial gastroenteritis worldwide, and most clinical cases appear as isolated, sporadic infections for which the source is rarely apparent. From July 2005 to December 2007 we conducted a prospective cas

Externí odkaz: https://doaj.org/article/dac08638582243c5a04fa4771a80af87

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Akademický článek

Polyantigenic interferon-γ responses are associated with protection from TB among HIV-infected adults with childhood BCG immunization.

Autor: Timothy Lahey, Brian K Mitchell, Robert D Arbeit, Siddharth Sheth, Mecky Matee, C Robert Horsburgh, Todd MacKenzie, Lillian Mtei, Muhammad Bakari, Jenni M Vuola, Kisali Pallangyo, C Fordham von Reyn

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e22074 (2011)

Surrogate immunologic markers for natural and vaccine-mediated protection against tuberculosis (TB) have not been identified.HIV-infected adults with childhood BCG immunization entering the placebo arm of the DarDar TB vaccine trial in Dar es Salaam,

Externí odkaz: https://doaj.org/article/d2915e0deb0d4b61a1c40f6107a55465

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Akademický článek

High-resolution melting system to perform multilocus sequence typing of Campylobacter jejuni.

Autor: Simon Lévesque, Sophie Michaud, Robert D Arbeit, Eric H Frost

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16167 (2011)

Multi-locus sequence typing (MLST) has emerged as the state-of-the-art method for resolving bacterial population genetics but it is expensive and time consuming. We evaluated the potential of high resolution melting (HRM) to identify known MLST allel

Externí odkaz: https://doaj.org/article/4e76e0b315fb4cf3a2fe54afe245adda

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