Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Robert Combes"'
The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This vo
Autor:
Michael Balls, Robert Combes
Publikováno v:
Alternatives to Laboratory Animals. 44:511-513
As a new consortium to promote animal experimentation is formed, the numbers of procedures reported to the UK Home Office continue to increase, and opportunities to replace them are not being taken
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb640e922ec7a212a9f8e1946235a17
https://doi.org/10.1177/026119291604400605
https://doi.org/10.1177/026119291604400605
Autor:
Robert Combes
Publikováno v:
Alternatives to laboratory animals : ATLA. 45(2)
Two hundred years after his seminal publication on the ‘shaking palsy’, what would James Parkinson now make of progress achieved in understanding and treating the disease that bears his name?
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953b64632f7b18a00948d56a885902ea
https://pubmed.ncbi.nlm.nih.gov/28598191
https://pubmed.ncbi.nlm.nih.gov/28598191
Autor:
Robert Combes, Michael Balls
Publikováno v:
Alternatives to laboratory animals : ATLA. 45(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44110a08a0b4cc99aeb5591f9af6fb34
https://pubmed.ncbi.nlm.nih.gov/28409993
https://pubmed.ncbi.nlm.nih.gov/28409993
Publikováno v:
Current Topics in Medicinal Chemistry. 8:1628-1655
In order to minimize expensive drug failures, is essential to determine potential activity, toxicity and ADME problems as early as possible. In view of the large libraries of compounds now being handled by combinatorial chemistry and high-throughput
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32e3410fd4455c0020c4aca649a52d2
https://doi.org/10.2174/156802608786786598
https://doi.org/10.2174/156802608786786598
Publikováno v:
Alternatives to Laboratory Animals. 36:111-122
This report presents some of the results of a joint research project, sponsored by Defra and conducted by FRAME and Liverpool John Moores University, on the status of alternatives to animal testing with regard to the European Union REACH (Registratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b24c88399eec36d778cfd51120d1036
https://doi.org/10.1177/026119290803601s09
https://doi.org/10.1177/026119290803601s09
Publikováno v:
Alternatives to Laboratory Animals. 36:139-147
This paper presents some results of a joint research project conducted by FRAME and Liverpool John Moores University, and sponsored by Defra, on the status of alternatives to animal testing with regard to the European Union REACH (Registration, Evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83306a70d0705eb50ea73a21625b0342
https://doi.org/10.1177/026119290803601s11
https://doi.org/10.1177/026119290803601s11
Publikováno v:
Alternatives to Laboratory Animals. 36:43-63
Liverpool John Moores University and FRAME recently conducted a research project sponsored by Defra, on the status of alternatives to animal testing with regard to the European Union REACH (Registration, Evaluation and Authorisation of Chemicals) sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c8ae20cbd7d25b979dcfd7093dec20
https://doi.org/10.1177/026119290803601s05
https://doi.org/10.1177/026119290803601s05
Autor:
Miguel Ángel Cabrera Pérez, Maykel Pérez González, M. Natália D. S. Cordeiro, Aliuska Morales Helguera, Robert Combes
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:3395-3407
Chemical carcinogenicity is of primary interest, because it drives much of the current regulatory actions regarding new and existing chemicals, and its conventional experimental test takes around three years to design, conduct, and interpret as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ceea99f869dc20d39deea2b95b2e81
https://doi.org/10.1016/j.bmc.2007.11.029
https://doi.org/10.1016/j.bmc.2007.11.029
Publikováno v:
Alternatives to Laboratory Animals. 36:65-80
Liverpool John Moores University and FRAME conducted a research project, sponsored by Defra, on the status of alternatives to animal testing with regard to the European Union REACH (Registration, Evaluation and Authorisation of Chemicals) system for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be52042dbb0b6e4f3939932175de3464
https://doi.org/10.1177/026119290803600108
https://doi.org/10.1177/026119290803600108