Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Robert Clarkson"'
Autor:
Alistair Robert Clarkson, Meta Killick
Publikováno v:
Voices, Vol 16, Iss 3 (2016)
This article introduces our development of the concepts of Community Music Therapy and systemic thinking within our music therapy service. The work, which was in a supported living setting for adults with learning disabilities (intellectual disabilit
Externí odkaz:
https://doaj.org/article/8c1fafec53d14fc5913623dd87d4158b
Autor:
Robert Clarkson, Robert J. Nash, Francis Xavier Wilson, Atsushi Kato, Alexander C. Weymouth-Wilson, Daniel Best, George W. J. Fleet, Saori Miyauchi, Chen Wang
Publikováno v:
Tetrahedron: Asymmetry. 21:311-319
A convenient large-scale synthesis of 1-deoxynojirimyin (DNJ) from d -glucuronolactone involves introduction of azide at C-5 with retention of configuration to give 5-azido-5-deoxy-1,2- O -isopropylidene-α- d -glucofuranose as a key intermediate in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9580453a28fa39007c134a610a3d4384
https://doi.org/10.1016/j.tetasy.2010.01.017
https://doi.org/10.1016/j.tetasy.2010.01.017
Autor:
Nigel A. Jones, M. S. Pino‐Gonzalez, Daniel Best, George W. J. Fleet, Robert Clarkson, Francis Xavier Wilson, Alexander C. Weymouth-Wilson
Publikováno v:
Tetrahedron Letters. 50:6307-6310
1,2-O-Isopropylidene-α-l-glucurono-3,6-lactone may be synthesized on a 100-200 g scale from cheaply available d-glucoheptonolactone in an overall yield of 94% in four steps via l-glucuronolactone. Subsequent elaboration to l-glucose, diacetone-l-glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765767c034296c8b4eec0f11286779c7
https://doi.org/10.1016/j.tetlet.2009.08.124
https://doi.org/10.1016/j.tetlet.2009.08.124
Autor:
Frank Burkamp, Kevin J. Hodgetts, Rajagopal Bakthavatchalam, Robert Clarkson, Hutchison Alan J, Stéphane De Lombaert, Daniel N. Cortright, A. Brian Jones, Charles A. Blum, Peter Blurton, Harry Brielmann, Xiaozhang Zheng, Jayaraman Chandrasekhar, Marci Crandall
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5217-5221
Bioisosteric replacement of piperazine with an aryl ring in lead VR1 antagonist 1 led to the biarylamide series. The development of B-ring SAR led to the conformationally constrained analog 70. The resulting aminoquinazoline 70 represents a novel VR1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfc1872ffb6d5bc79dc219aaca6d3f4
https://doi.org/10.1016/j.bmcl.2006.07.010
https://doi.org/10.1016/j.bmcl.2006.07.010
Autor:
S. L. Shepheard, Peter H. Hutson, Desmond O'Connor, Linda J. Bristow, Peter Blurton, G.P. Cook, Graham D Bentley, Rose Marwood, Stephen Robert Fletcher, Angus Murray Macleod, José L. Castro, Frank Burkamp, Robert Clarkson, Matthew T. Tudge, Daniel Spinks, Monique Bodil Van Niel, Smita Patel, Kerry L. Chapman, Susan K. F. Cheng
Publikováno v:
Journal of Medicinal Chemistry. 45:492-503
On the basis of a spirocyclic ether screening lead, a series of acyclic sulfones have been identified as high-affinity, selective 5-HT(2A) receptor antagonists. Bioavailability lacking in the parent, 1-(2-(2,4-difluorophenyl)ethyl)-4-(phenylsulfonyl)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afa4fc4cadf21e96b0a58afc824c74f
https://doi.org/10.1021/jm011030v
https://doi.org/10.1021/jm011030v
Autor:
Robert Clarkson, Peter Blurton, Peter H. Hutson, Cheryl L. Barton, M T Jay, Frank Burkamp, Linda J. Bristow
Publikováno v:
Neuropharmacology. 39:2318-2328
Administration of the non-competitive NMDA receptor antagonists phencyclidine (PCP) (0.6-5 mg/kg s.c.) and MK-801 (0.1-0.8 mg/kg s.c. ) dose-dependently increased locomotor activity in the rat. Pre-treatment of rats with SB 221284 (0.1-1 mg/kg, i.p.)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54927c2e9514f14dae0704bb08dad086
https://doi.org/10.1016/s0028-3908(00)00089-7
https://doi.org/10.1016/s0028-3908(00)00089-7
Autor:
David J. Watkin, George W. J. Fleet, Alexander C. Weymouth-Wilson, Sarah F. Jenkinson, Robert Clarkson, Daniel Best
Publikováno v:
Acta Crystallographica Section E: Structure Reports
X-ray crystallographic analysis has established that the major product from the protection of d-glucoronolactone with benzaldehyde is (1S)-1,2-O-benzyl-idene-α-d-glucurono-6,3-lactone, C(13)H(12)O(6), rather than the R epimer. The crystal structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23f11ec6bc681b7bc32a703b246fedf
http://ora.ox.ac.uk/objects/uuid:964ba715-34eb-4fe2-8591-99197b564ae1
http://ora.ox.ac.uk/objects/uuid:964ba715-34eb-4fe2-8591-99197b564ae1
Autor:
Alexander C. Weymouth-Wilson, Thomas Heinz, Sarah F. Jenkinson, Robert Clarkson, George W. J. Fleet, Filipa P. da Cruz, David J. Hotchkiss, Nigel A. Jones, Kathrine V. Booth
Publikováno v:
TETRAHEDRON-ASYMMETRY. 19(20)
Readily crystallized 2-C-methyl-d-ribono-1,4-lactone is formed in a one-pot procedure from d-glucose without any protecting groups by treatment with dimethylamine to give an Amadori ketose and then with aqueous calcium hydroxide in yields of approxim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0458628803b46925a24d205e23d33868
http://ora.ox.ac.uk/objects/uuid:9a3c3d1c-d54e-4e2e-aea5-5cbe5f7eff45
http://ora.ox.ac.uk/objects/uuid:9a3c3d1c-d54e-4e2e-aea5-5cbe5f7eff45