Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Robert Chott"'
Autor:
Randall J. Bateman, Tom Kasten, Wendy Sigurdson, Robert Chott, Bruce W. Patterson, Tammie L.S. Benzinger, Kevin E. Yarasheski, Lily Zhang, John C. Morris, Shengmei Ma, Kwasi G. Mawuenyega, Alison Goate, David M. Holtzman, Donald L. Elbert, Chengjie Xiong, Vitaliy Ovod
Publikováno v:
Annals of Neurology. 78:439-453
Objective Age is the single greatest risk factor for Alzheimer's disease (AD), with the incidence doubling every 5 years after age 65. However, our understanding of the mechanistic relationship between increasing age and the risk for AD is currently
Autor:
Kevin E. Yarasheski, Robert C. Bucelli, Timothy M. Miller, Randall J. Bateman, Jennifer Jockel-Balsarotti, Conrad C. Weihl, Matthew J. Crisp, Wade K. Self, Kwasi G. Mawuenyega, Bruce W. Patterson, Robert Chott, Arun S. Varadhachary, Naveen C. Reddy
Publikováno v:
Journal of Clinical Investigation. 125:2772-2780
Therapeutic strategies that target disease-associated transcripts are being developed for a variety of neurodegenerative syndromes. Protein levels change as a function of their half-life, a property that critically influences the timing and applicati
Autor:
Guoxin Wu, Kristin R. Wildsmith, Andrew Stamford, Kevin E. Yarasheski, Matthew E. Kennedy, David B. Gilberto, Yuriy Pyatkivskyy, Randall J. Bateman, Daniel J. Holder, Mary J. Savage, Robert Chott, Debra A. McLoughlin, Justyna Dobrowolska, Bruce W. Patterson, Mandy Dancho, Tom Kasten, Vitaliy Ovod, Parker Mathers, Maria S. Michener, Christina Lennox, Brad E. Smith
Publikováno v:
Journal of Neuroscience. 34:8336-8346
BACE, a β-secretase, is an attractive potential disease-modifying therapeutic strategy for Alzheimer's disease (AD) as it results directly in the decrease of amyloid precursor protein (APP) processing through the β-secretase pathway and a lowering
Autor:
Paul Kelly, C Prakash Gyawali, Victor Mudenda, Edford Sinkala, Catherine Anderson-Spearie, Stayner Mwanamakondo, Kevin E. Yarasheski, Akwi W. Asombang, Deborah C. Rubin, Robert Chott, Mpala Mwanza-Lisulo, Graham A. Colditz, Violet Kayamba
Publikováno v:
The American Journal of Clinical Nutrition. 97:1029-1035
Background: Gastric cancer is increasingly recognized in Zambia. Although nutritional factors contribute to gastric cancer risk, their effect in Zambia is unknown. Objective: The objective was to investigate the association between intake of dietary
Autor:
Gerritje J.W. van der Windt, Bart Everts, Robert Chott, Kevin E. Yarasheski, Tori C. Freitas, Edward J. Pearce, Erika L. Pearce, Eyal Amiel
Publikováno v:
Blood
Blood, 120(7), 1422-1431. American Society of Hematology
Blood, 120(7), 1422-1431. American Society of Hematology
TLR agonists initiate a rapid activation program in dendritic cells (DCs) that requires support from metabolic and bioenergetic resources. We found previously that TLR signaling promotes aerobic glycolysis and a decline in oxidative phosphorylation (
Autor:
Chihiro Sato, Jennifer Jockel-Balsarotti, Randall J. Bateman, Nicolas R. Barthélemy, Kwasi G. Mawuenyega, Kevin E. Yarasheski, Robert Chott, Tom Kasten, Bruce W. Patterson, Timothy M. Miller
Publikováno v:
Alzheimer's & Dementia. 11
Autor:
Bruce W, Patterson, Donald L, Elbert, Kwasi G, Mawuenyega, Tom, Kasten, Vitaliy, Ovod, Shengmei, Ma, Chengjie, Xiong, Robert, Chott, Kevin, Yarasheski, Wendy, Sigurdson, Lily, Zhang, Alison, Goate, Tammie, Benzinger, John C, Morris, David, Holtzman, Randall J, Bateman
Publikováno v:
Annals of neurology. 78(3)
Age is the single greatest risk factor for Alzheimer's disease (AD), with the incidence doubling every 5 years after age 65. However, our understanding of the mechanistic relationship between increasing age and the risk for AD is currently limited. W
Autor:
Robert A. Swarm, John C. Morris, Ping Yan, Randall J. Bateman, Chengjie Xiong, Yvette I. Sheline, Mateusz S. Jasielec, Mark A. Mintun, Whitney D. Ficker, Jonathan R. Fisher, John R. Cirrito, Christine Frederiksen, Jin-Moo Lee, Kevin E. Yarasheski, Monica V. Grzelak, Robert Chott, Tim West
Publikováno v:
Science Translational Medicine. 6
Serotonin signaling suppresses generation of amyloid-β (Aβ) in vitro and in animal models of Alzheimer’s disease (AD). We show that in an aged transgenic AD mouse model (APP/PS1 plaque-bearing mice), the antidepressant citalopram, a selective ser
Autor:
Matthew E. Kennedy, Brad Smith, Guoxin Wu, Kevin E. Yarasheski, Christina Lennox, Randall J. Bateman, Justyna Dobrowolska, Dan Holder, Andrew Stamford, Yuriy Pyatkivskyy, Kristin R. Wildsmith, Mandy Dancho, Tom Kasten, Maria S. Michener, Vitaliy Ovod, Parker Mathers, Debra A. McLoughlin, Bruce W. Patterson, David B. Gilberto, Robert Chott, Mary J. Savage
Publikováno v:
Alzheimer's & Dementia. 9
Autor:
John R. Cirrito, Christine Frederiksen, Karen J. Regina, Evan D. Kharasch, Robert Chott, Robert A. Swarm, Tim West, Kevin E. Yarasheski, Yvette I. Sheline
Publikováno v:
Alzheimer's & Dementia. 9