Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Robert Child"'
Autor:
Alyson J. Smith, Shannon M. Miller, Cassandra Buhl, Robert Child, Margaret Whitacre, Roman Schoener, George Ettenger, David Burkhart, Kendal Ryter, Jay T. Evans
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Despite the ever present need for an effective Mycobacterium tuberculosis (Mtb) vaccine, efforts for development have been largely unsuccessful. Correlates of immune protection against Mtb are not wholly defined, but Th1 and likely Th17 adaptive immu
Externí odkaz:
https://doaj.org/article/be15d9495c834bfea241ccae8fbb3636
Publikováno v:
mBio, Vol 7, Iss 6 (2016)
ABSTRACT Brucella abortus, the bacterial agent of the worldwide zoonosis brucellosis, primarily infects host phagocytes, where it undergoes an intracellular cycle within a dedicated membrane-bound vacuole, the Brucella-containing vacuole (BCV). Initi
Externí odkaz:
https://doaj.org/article/42b8300053ea47208c46580f0162ca5f
Autor:
Maarten F. de Jong, Tregei Starr, Maria G. Winter, Andreas B. den Hartigh, Robert Child, Leigh A. Knodler, Jan Maarten van Dijl, Jean Celli, Renée M. Tsolis
Publikováno v:
mBio, Vol 4, Iss 1 (2013)
ABSTRACT Host cytokine responses to Brucella abortus infection are elicited predominantly by the deployment of a type IV secretion system (T4SS). However, the mechanism by which the T4SS elicits inflammation remains unknown. Here we show that translo
Externí odkaz:
https://doaj.org/article/708e716606f1474fb06f4ac852025a7a
Autor:
Audrey Chong, Robert Child, Tara D Wehrly, Dedeke Rockx-Brouwer, Aiping Qin, Barbara J Mann, Jean Celli
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67965 (2013)
Francisella tularensis is a highly infectious bacterium whose virulence relies on its ability to rapidly reach the macrophage cytosol and extensively replicate in this compartment. We previously identified a novel Francisella virulence factor, DipA (
Externí odkaz:
https://doaj.org/article/5cab4600db4a4ef19ec4c01080f2108b
Autor:
Sebenzile Myeni, Robert Child, Tony W Ng, John J Kupko, Tara D Wehrly, Stephen F Porcella, Leigh A Knodler, Jean Celli
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003556 (2013)
The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV) derived from the endoplasmic reticulum via subversion of the host cell secretory pathway. rBCV biogenesis requires the expression of the Type IV secretion system (
Externí odkaz:
https://doaj.org/article/34971f7e393b47f89c27fac22e30ea47
Autor:
Dedeke Rockx-Brouwer, Audrey Chong, Tara D Wehrly, Robert Child, Deborah D Crane, Jean Celli, Catharine M Bosio
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37752 (2012)
Tularemia, caused by the gram-negative bacterium Francisella tularensis, is a severe, sometimes fatal disease. Interest in tularemia has increased over the last decade due to its history as a biological weapon. In particular, development of novel vac
Externí odkaz:
https://doaj.org/article/354bf3ef51e0422b8362ef4ce631232c
Autor:
George Ettenger, Shannon M. Miller, Robert Child, Omer K. Rasheed, Kendal T. Ryter, Jay T. Evans, Alyson J. Smith, Cassandra Buhl, David C. Holley
Publikováno v:
Journal of Medicinal Chemistry. 63:309-320
Mycobacterium tuberculosis (Mtb) continues to be a major health threat worldwide, and the development of Mtb vaccines could play a pivotal role in the prevention and control of this devastating epidemic. Th17-mediated immunity has been implicated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b356d5b12be65554086f4324ddff5d96
https://doi.org/10.1021/acs.jmedchem.9b01598
https://doi.org/10.1021/acs.jmedchem.9b01598
Autor:
Harry E. Ensley, Kendal T. Ryter, David L. Williams, Robert Child, Jay T. Evans, Bridget M. Graves, Peter J. Rice, Alyson J. Smith, Zuchao Ma, Douglas W. Lowman
Publikováno v:
The Journal of Immunology. 200:788-799
Ligation of Dectin-1 by fungal glucans elicits a Th17 response that is necessary for clearing many fungal pathogens. Laminarin is a (1→3, 1→6)-β-glucan that is widely reported to be a Dectin-1 antagonist, however, there are reports that laminari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9e0a93b2854d52069135f9732c6a158
https://doi.org/10.4049/jimmunol.1701258
https://doi.org/10.4049/jimmunol.1701258
Autor:
Robert Child
The remarkable story of the seven African American soldiers ultimately awarded the World War II Medal of Honor, and the 50-year campaign to deny them their recognition. In 1945, when Congress began reviewing the record of the most conspicuous acts of
Autor:
Kendal T, Ryter, George, Ettenger, Omer K, Rasheed, Cassandra, Buhl, Robert, Child, Shannon M, Miller, David, Holley, Alyson J, Smith, Jay T, Evans
Publikováno v:
J Med Chem
Mycobacterium tuberculosis (Mtb) continues to be a major health threat worldwide and the development of Mtb vaccines could play a pivotal role in the prevention and control of this devastating epidemic. Th17 mediated immunity has been implicated in d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e8f09415c47e8bb2df3ec6c7c6e752ad
https://pubmed.ncbi.nlm.nih.gov/31809053
https://pubmed.ncbi.nlm.nih.gov/31809053