Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Robert Cashon"'
Publikováno v:
Biochemical Journal. 330:375-382
This report provides the first evidence for the existence of two distinct types of fatty acid-binding protein (FABP) in cardiac tissue of vertebrates. Four species of Antarctic teleost fish (Chaenocephalus aceratus, Cryodraco antarcticus, Gobionototh
Publikováno v:
Comparative Biochemistry and Physiology Part A: Physiology. 109:1085-1095
The hemolysate of Mastigodryas bifossatus shows two major hemoglobins with very close isoelectric points, and four different globin chains. The stripped hemolysate exhibits a low alkaline Bohr effect (Δlog P 50 / Δ pH = −0.30 between pH7 and 8) a
Publikováno v:
Journal of Molecular Biology. 239:561-568
In the human hemoglobin variant Hb Hinsdale, lysine is substituted for asparagine at position β139 (H17), which lies in the water-filled cavity that runs through the center of the molecule. This substitution adds two extra cationic residues to the e
Publikováno v:
Artificial Cells, Blood Substitutes, and Biotechnology. 22:373-386
The rapid unloading of oxygen to tissue and the prevention of subunit dissociation have been the main concerns in the search for an effective hemoglobin-based red cell substitute. The presence of redox active iron however, raises some questions about
Publikováno v:
Archives of Biochemistry and Biophysics. 303:332-338
We have examined the interactions between nitric oxide (NO) and oxidized human hemoglobin, comparing the behavior of unmodified HbA0 with that of two chemically modified hemoglobins. The latter are promising red cell substitute candidates due to thei
Publikováno v:
Marine Environmental Research. 35:13-17
In the blue crab Callinectes sapidus , a direct correlation exists between the levels of Cu(I)-metallothionein (CuMT) and Cu(I)-hemocyanin during the molt cycle. However, CuMT cannot directly restore the oxygen-binding capacity of copperless hemocyan
Publikováno v:
Journal of Biological Chemistry. 267:4652-4657
Heat-shocked organisms are known to produce not only "heat shock proteins" but also diadenosine tetraphosphate (Ap4A) and related compounds that may act as "alarmones" that alert the cell to the onset of metabolic stress. We found that Ap4A is synthe
Publikováno v:
Journal of Biological Chemistry. 266:23033-23040
Hemoglobin (Hb) Chico (Lys beta 66----Thr at E10) has a diminished oxygen affinity (Shih, D. T.-b., Jones, R. T., Shih, M. F.-C., Jones, M. B., Koler, R. D., and Howard, J. (1987) Hemoglobin 11, 453-464). Our studies show that its P50 is about twice
Publikováno v:
Biotechnology and Bioengineering. 35:831-836
Complex coacervation is a phenomenon of phase separation that may occur in a solution of positively and negatively charged polyions. The resulting two phases are distinguished by the total concentration of both polyions, with the concentrated phase o
Publikováno v:
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology. 20(2-4)
We have examined the covalent modification of HbA with BPC (benzenepentacarboxylate) whose carboxyl groups were activated with EDC [1-ethyl-3-(3-dimethyl- aminopropyl)-carbodiimide]. Reaction of deoxy-HbA at pH 8 with a 10-fold excess of BPC, preacti