Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Robert C.T. McKenzie"'
Autor:
Maria Demontis, Silvia A. Ferreira, Rosie M. Butler, Christine L. Jones, Tracey J. Mitchell, Isabella Tosi, Charlotte E. Flanagan, Robert C.T. McKenzie, Wesley J. Woollard, Sean Whittaker, Susan D. John
Publikováno v:
Butler, R M, Mckenzie, R C, Jones, C L, Flanagan, C E, Woollard, W J, Demontis, M, Ferreira, S, Tosi, I, John, S, Whittaker, S J & Mitchell, T J 2019, ' Contribution of STAT3 and RAD23B in Primary Sézary Cells to Histone Deacetylase Inhibitor FK228 Resistance ', Journal of Investigative Dermatology, vol. 139, no. 9, pp. 1975-1984.e2 . https://doi.org/10.1016/j.jid.2019.03.1130
FK228 (romidepsin) and suberoylanilide hydroxamic acid (vorinostat) are histone deacetylase inhibitors (HDACi) approved by the US Food and Drug Administration for cutaneous T-cell lymphoma (CTCL), including the leukemic subtype Sezary syndrome. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c639eeccf4bbbe400c2de80d80080b01
https://kclpure.kcl.ac.uk/ws/files/110043202/PIIS0022202X19313405.pdf
https://kclpure.kcl.ac.uk/ws/files/110043202/PIIS0022202X19313405.pdf
Autor:
Wes Woollard, Robert C.T. McKenzie, Jae Jin Lee, Rosie M. Butler, Carl Z. Beyers, Lam Tung, Bjorn Rhys Thomas, Catherine Roper, Isabella Tosi, Sean Whittaker, Tracey J. Mitchell, Silvia Ferreira, Christine L. Jones, Nithyha P. Kalaivani, Anna Lorenc
Publikováno v:
Journal of Investigative Dermatology. 136:1238-1246
Methylthioadenosine phosphorylase ( MTAP ) and the tumor suppressor genes CDKN2A - CDKN2B are frequently deleted in malignancies. The specific role of MTAP in cutaneous T-cell lymphoma subgroups, mycosis fungoides (MF) and Sezary syndrome (SS), is un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cb39b4a10938928022bb225943732b
https://doi.org/10.1016/j.jid.2016.01.028
https://doi.org/10.1016/j.jid.2016.01.028
Autor:
Silvia Ferreira, Isabella Tosi, Christine L. Jones, Tracey J. Mitchell, Robert C.T. McKenzie, Martine Bagot, Sean Whittaker, Jacqueline A. Caesar
Publikováno v:
Journal of Investigative Dermatology. 132:2042-2049
T-plastin (PLS3) is an actin-bundling protein normally expressed in epithelial cells but absent in cells of hematopoietic origin. Aberrant PLS3 expression has been demonstrated in lymphocytes from Sézary syndrome (SS) patients and has been proposed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed98e9a39e4f243829f2cd30efbea0d
https://doi.org/10.1038/jid.2012.106
https://doi.org/10.1038/jid.2012.106
Autor:
Sean Whittaker, Robert C.T. McKenzie, Christine L. Jones, Isabella Tosi, Tracey J. Mitchell, J. A. Caesar
Publikováno v:
Leukemia. 26:323-331
Constitutive and persistent activation of STAT3 has been implicated in the pathogenesis of many malignancies. Studies of CTCL cell lines have previously suggested that aberrant activation of STAT3 is mediated via silencing of the negative regulator S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3bb5e119fd41e4900317cfce6a65d17
https://doi.org/10.1038/leu.2011.198
https://doi.org/10.1038/leu.2011.198
Autor:
Rosalind Foster, Christine L. Jones, Chung-Ching Chu, Isabella Tosi, Sean Whittaker, Robert C.T. McKenzie, E. Mary Wain, Tracey J. Mitchell
Publikováno v:
Journal of Investigative Dermatology. 130(4):1116-1125
Sezary Syndrome (SS) is an aggressive leukemic variant of primary cutaneous T-cell lymphoma characterized by the presence of tumor or Sezary cells that generally display a mature memory T-cell immunophenotype. Sezary cells proliferate poorly and ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6431a51815e4b1b64b28a4046d6c4947