Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Robert C. Wells"'
Autor:
Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport vehicle targeting the CD98 heavy chain (CD98hc or SLC3
Externí odkaz:
https://doaj.org/article/c0dcaba8ffc04890ade94c8b75b21509
Autor:
Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a16cb8fb950d46f9ab274a050ec42452
Autor:
Scarlett J Barker, Mai B Thayer, Chaeyoung Kim, David Tatarakis, Matthew Simon, Rebekah L Dial, Lizanne Nilewski, Robert C Wells, Yinhan Zhou, Megan Afetian, Alfred Chappell, Kylie S Chew, Johann Chow, Allisa Clemens, Claire B Discenza, Jason Dugas, Chrissa Dwyer, Timothy Earr, Connie Ha, David Huynh, Srini Jayaraman, Wanda Kwan, Cathal Mahon, Michelle Pizzo, Elysia Roche, Laura Sanders, Alexander Stergioulis, Raymond Tong, Hai Tran, Joy Zuchero, Anthony A Estrada, Kapil Gadkar, Christopher MM Koth, Pascal E Sanchez, Robert G Thorne, Ryan J Watts, Thomas Sandmann, Lesley Kane, Frank Rigo, Mark S Dennis, Joseph W Lewcock, Sarah L DeVos
Antisense oligonucleotides (ASO) are promising therapies for neurological disorders, though they are unable to cross the blood-brain barrier (BBB) and must be delivered directly to the central nervous system (CNS). Here, we use a human transferrin re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56046f97df89d6a2d15a721b2fca4f31
https://doi.org/10.1101/2023.04.25.538145
https://doi.org/10.1101/2023.04.25.538145
Autor:
Sarah L. DeVos, Y. Joy Yu Zuchero, Jennifer A. Getz, Tina Giese, Michelle E. Pizzo, Meredith E. K. Calvert, Robert C. Wells, Ryan J. Watts, Mark S. Dennis, Sulochanadevi Baskaran, Takashi Miyamoto, Xiaocheng Chen, Kylie S. Chew, Yin Zhang, Raymond K. Tong, Victoria A. Assimon, Ankita Srivastava, Adam P. Silverman, Kane Lesley Ann, Sejal S. Hall, Zachary Kevin Sweeney, Catherine Bedard, Katherine Jenkins, Mihalis Kariolis, Kwan Wanda, Do Jin Kim, Robert G. Thorne, Pascal E. Sanchez, Kirk R. Henne, Hilda Solanoy, Nicholas Liang, Cathal Mahon
Publikováno v:
Science Translational Medicine. 12
Effective delivery of protein therapeutics to the central nervous system (CNS) has been greatly restricted by the blood-brain barrier (BBB). We describe the development of a BBB transport vehicle (TV) comprising an engineered Fc fragment that exploit
Autor:
Adam P. Silverman, Kwan Wanda, Junhua Wang, Alicia A. Nugent, Giuseppe Astarita, Ullman Julie, Nicholas Liang, Catherine Bedard, Sonnet S. Davis, Dolores Diaz, Gilbert Di Paolo, Anastasia G. Henry, Jennifer A. Getz, Hai L. Tran, Jason C. Dugas, Kannan Gunasekaran, Ankita Srivastava, Ryan J. Watts, Suresh Poda, Connie W.Y. Ha, Vinay M. Daryani, Sejal S. Hall, Ritesh Ravi, Michael Tuck, Thomas Sandmann, Robert C. Wells, Richard M. Caprioli, Cathal Mahon, Robert G. Thorne, Hilda Solanoy, Michelle L. Reyzer, Akhil Bhalla, Steve Lianoglou, Mihalis Kariolis, Pascal E. Sanchez, Jessica R. Blumenfeld, Timothy K. Earr, Kirk R. Henne, Hoang Nguyen, Jennifer L. Harvey, Joseph Duque, Do Jin Kim, Mark S. Dennis, Zachary Kevin Sweeney, Tina Giese, Annie Arguello
Publikováno v:
Science Translational Medicine. 12
Most lysosomal storage diseases (LSDs) involve progressive central nervous system (CNS) impairment, resulting from deficiency of a lysosomal enzyme. Treatment of neuronopathic LSDs remains a considerable challenge, as approved intravenously administe
Autor:
Robert C Wells, R Blake Hill
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21384 (2011)
Every lipid membrane fission event involves the association of two apposing bilayers, mediated by proteins that can promote membrane curvature, fusion and fission. We tested the hypothesis that Fis1, a tail-anchored protein involved in mitochondrial
Externí odkaz:
https://doaj.org/article/f2ef436fd647428aa6695af66c60ff49
Autor:
Jennifer A. Getz, Mihalis Kariolis, Jessica R. Blumenfeld, Annie Arguello, Anastasia G. Henry, Ankita Srivastava, Giuseppe Astarita, Kirk R. Henne, Kannan Gunasekaran, Robert C. Wells, Tina Giese, Akhil Bhalla, Cathal Mahon, Adam P. Silverman, Hai L. Tran, Mark S. Dennis, Joseph Duque, Catherine Bedard, Zachary Kevin Sweeney, Ryan J. Watts, Dolo Diaz, Junhua Wang, Nicholas Liang, Ullman Julie, Do Jin Kim
Publikováno v:
Molecular Genetics and Metabolism. 126:S72
Most lysosomal storage diseases (LSDs) involve progressive central nervous system (CNS) impairment resulting from deficiency in one or more lysosomal enzymes. Treatment of neuronopathic LSDs remains a considerable challenge, as the recombinant enzyme
Autor:
Robert C. Wells, Michael Lagunoff, Almira S. Punjabi, Richard Vart, Cristina J. Wittkopp, Valerie A. Morris
Publikováno v:
Virology. 428(2):112-120
The predominant tumor cell of Kaposi's Sarcoma (KS) is the spindle cell, a cell of endothelial origin that expresses markers of lymphatic endothelium. In culture, Kaposi's Sarcoma-associated herpesvirus (KSHV) infection of blood endothelial cells dri
Publikováno v:
Protein Science. 20:62-74
Bcl-2 proteins associate with and remodel mitochondria to regulate apoptosis. While the C. elegans Bcl-2 homolog CED-9 constitutively associates with mitochondria, it is unclear whether or not this association reflects an innate ability of CED-9 to d
Autor:
Robert C Wells
Publikováno v:
Personalized Medicine. 6:235-239
On 20 January 2009, a jubilant crowd of almost 2,000,000 spectators jammed shoulder-toshould er on the National Mall in Washington [DC, USA] to witness the inauguration of Barack Obama as the 44th President of the USA. As well as the many other histo