Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Robert C. Vallari"'
Autor:
Robert C. Vallari, W. James Cook, Deborah C. Audino, Michael J. Morgan, Donna E. Jensen, Andrew P. Laudano, Clyde L. Denis
Publikováno v:
Molecular and Cellular Biology. 12:1663-1673
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b58e1c60f390356d539232e072a5298
https://doi.org/10.1128/mcb.12.4.1663-1673.1992
https://doi.org/10.1128/mcb.12.4.1663-1673.1992
Autor:
Regina Pietruszko, Robert C. Vallari
Publikováno v:
Archives of Biochemistry and Biophysics. 212:9-19
The kinetic mechanism of human liver aldehyde dehydrogenase, E1, was investigated at pH 7.2 using initial velocity, product inhibition, dead end inhibition, and pre-steady-state techniques. Only NADH, which was found to be competitive with NAD+ at hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab7aa2a410d2b71e613a900a83c1c0d
https://doi.org/10.1016/0003-9861(81)90338-6
https://doi.org/10.1016/0003-9861(81)90338-6
Publikováno v:
FEBS Letters. 179:77-81
A derivative and possible physiological metabolite of disulfiram, diethyldithiocarbamic acid methanethiol mixed disulfide, is shown here for the first time to inactivate the mitochondrial low-Km, isozyme of human aldehyde dehydrogenase (EC 1.2.1.3).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4408f82d5b582b4ecaa4ce16ce616fc4
https://doi.org/10.1016/0014-5793(85)80195-2
https://doi.org/10.1016/0014-5793(85)80195-2
Autor:
Robert C. Vallari, Regina Pietruszko
Publikováno v:
FEBS Letters. 92:89-91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9031ee0e7355b167237e7d3581ba5c51
https://doi.org/10.1016/0014-5793(78)80728-5
https://doi.org/10.1016/0014-5793(78)80728-5
Publikováno v:
Alcohol and Aldehyde Metabolizing Systems-IV ISBN: 9781475714210
The El isoenzyme of human liver aldehyde dehydrogenase (Km acetaldehyde = 30uM, pH 7.0), when incubated with disulfiram at a stoichiometry of four moles disulfiram/tetrameric El, is immediately inhibited to within 10% of control activity. The inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::743a4537662cb5fffc566c2b151a652a
https://doi.org/10.1007/978-1-4757-1419-7_5
https://doi.org/10.1007/978-1-4757-1419-7_5
Autor:
Regina Pietruszko, Robert C. Vallari
Publikováno v:
Science (New York, N.Y.). 216(4546)
Disulfiram labeled with carbon-14 reacts specifically with human liver aldehyde dehydrogenase E1 with loss of catalytic activity and no incorporation of label. Carbon-14-labeled diethyldithiocarbamate is formed and the number of enzyme sulfhydryl gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1d74a005173bf5e7387f5546b377d1
https://pubmed.ncbi.nlm.nih.gov/7071604
https://pubmed.ncbi.nlm.nih.gov/7071604
Autor:
Rollin J. Hawley, L. Franklin Major, Regina Pietruszko, Donna M. Reed, Nirmal Saini, Robert C. Vallari
Publikováno v:
Alcoholism, clinical and experimental research. 5(1)
Human postmortem brain samples from temporal lobe of 23 alcoholics and 19 controls (13 with cancer and six without cancer) were used for determination of low Km (micromolar) and high Km (millimolar) aldehyde dehydrogenase activity. Despite histories
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6b7e863df4a764dff2fbefba2e014e
https://pubmed.ncbi.nlm.nih.gov/7013552
https://pubmed.ncbi.nlm.nih.gov/7013552