Výsledky vyhledávání - "Robert C. Tam"

Abstract 2138: Creating next-generation biologics using a novel chemistry platform technology

Autor: Vijaya R. Pattabiraman, Matilde Arévalo Ruiz, Régis Boehringer, Benoit Hornsperger, Roy Meoded, Robert C. Tam, Bertolt Kreft

Publikováno v: Cancer Research. 82:2138-2138

Bright Peak Therapeutics is developing a portfolio of differentiated biotherapeutics using chemistry for applications in immuno-oncology and autoimmune diseases. Our unique chemical protein synthesis and engineering platform allows us to fine-tune cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a68f4f148747db1ba6e822707eddf2cf
https://doi.org/10.1158/1538-7445.am2022-2138

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Comparative Analysis of Anti-Hepatitis C Virus Activity and Gene Expression Mediated by Alpha, Beta, and Gamma Interferons

Autor: Johnson Y.N. Lau, Tessa Brodhag, I. Wayne Cheney, Weidong Zhong, Vicky C. H. Lai, Zhi Hong, Charmaine Lim, Shannon Dempsey, Robert C. Tam

Publikováno v: Journal of Virology. 76:11148-11154

A direct comparison of the inhibitory effects of alpha, beta, and gamma interferons (IFNs) on replication of a hepatitis C virus subgenomic replicon in a hepatoma cell line revealed similarities in antiviral potency. However, alternate IFN-induced an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05910ca30c8194fd665bcccd84b4575a
https://doi.org/10.1128/jvi.76.21.11148-11154.2002

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Mechanisms of Action of Ribavirin in Antiviral Therapies

Autor: Robert C. Tam, Johnson Y.N. Lau, Zhi Hong

Publikováno v: Antiviral Chemistry and Chemotherapy. 12:261-272

Although ribavirin was originally synthesized over 30 years ago and has been used to treat viral infections as monotherapy (respiratory syncytial virus and Lassa fever virus) or with interferon-α (IFN-α) as combination therapy (hepatitis C virus),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc1b0ef252c8988efc3eaa943f53769
https://doi.org/10.1177/095632020101200501

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Therapeutic Strategies Targeting the Innate Antiviral Immune Response

Autor: Miriana Moran, Z. H. I. Hong, Sung-Kwon Kim, Andrei Varnavski, Robert C. Tam

Publikováno v: Biopharmaceutical Drug Design and Development ISBN: 9781588297167

Sensing the presence of pathogens and responding quickly is one of the most important tasks during the early or innate immune response. This evolutionarily conserved immune system orchestrates the elimination of pathogens of viral, bacterial, and par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7535f065eaf35d769e92469ee1e23990
https://doi.org/10.1007/978-1-59745-532-9_11

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Inhibition of CD28 expression by oligonucleotide decoys to the regulatory element in exon 1 of the CD28 gene

Autor: Robert C. Tam, Catherine J. Lin, Charmaine Lim, Bharati Pai, Vesna Stoisavljevic

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(8)

Ligation of CD28 provides a costimulatory signal essential for Ag-mediated T cell activation via the TCR. Previously we demonstrated that inhibition of human and murine CD28 expression by a guanosine (G)-rich oligonucleotide (ODN), GR1, led to immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d545fd298ef1ff4f40fcd2dbe77a7c59
https://pubmed.ncbi.nlm.nih.gov/10510368

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